Ponicidin inhibits cell growth on hepatocellular carcinoma cells by induction of apoptosis

Abstract Background and Aim Ponicidin is recently reported to have anti-tumour effects on a large variety of cancers. The present study was undertaken to investigate the anti-proliferation effects of ponicidin on hepatocellular carcinoma cells and its mechanism. Methods Two hepatocellular carcinoma...

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Veröffentlicht in:	Digestive and liver disease 2007-02, Vol.39 (2), p.160-166
Hauptverfasser:	Zhang, J.-F, Liu, P.-Q, Chen, G.-H, Lu, M.-Q, Cai, C.-J, Yang, Y, Li, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Bax Bcl-2 bcl-2-Associated X Protein - biosynthesis Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Survival - drug effects Diterpenes - pharmacology DNA Fragmentation Gastroenterology and Hepatology Hepatocellular carcinoma Humans Inhibitor of Apoptosis Proteins Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - pathology Microtubule-Associated Proteins - biosynthesis Neoplasm Proteins - biosynthesis Ponicidin Proto-Oncogene Proteins c-bcl-2 - biosynthesis Survivin Tumor Cells, Cultured
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