A comparison of factors associated with collagen metabolism in different skeletal muscles from dystrophic (mdx) mice: Impact of pirfenidone

Skeletal muscles in mdx mice exhibit differential degrees of pathological changes and fibrosis. The purpose of this study was to examine differences in various indices of collagen metabolism in skeletal muscles with widely different functions and activity profiles in mdx mice, and to determine wheth...

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Veröffentlicht in:	Muscle & nerve 2007-02, Vol.35 (2), p.208-216
Hauptverfasser:	Gosselin, Luc E., Williams, Jacqueline E., Personius, Kirkwood, Farkas, Gaspar A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Biological and medical sciences Chromatography, High Pressure Liquid - methods Collagen - metabolism connective tissue diaphragm Disease Models, Animal Diseases of striated muscles. Neuromuscular diseases drug therapy Fibrosis - etiology Fibrosis - metabolism Fibrosis - pathology Fundamental and applied biological sciences. Psychology In Vitro Techniques inflammation Isometric Contraction - drug effects Isometric Contraction - physiology Male Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Medical sciences Mice Mice, Inbred C57BL Mice, Inbred mdx Muscle, Skeletal - metabolism muscular dystrophy Muscular Dystrophy, Duchenne - drug therapy Muscular Dystrophy, Duchenne - genetics Muscular Dystrophy, Duchenne - pathology Neurology Pyridones - therapeutic use Reverse Transcriptase Polymerase Chain Reaction - methods Striated muscle. Tendons Transforming Growth Factor beta1 - metabolism Vertebrates: osteoarticular system, musculoskeletal system
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