Morpheus Unbound: Reimagining the Morphogen Gradient
The theory that the spatial organization of cell fate is orchestrated by gradients of diffusing molecules was a major contribution to 20 th century developmental biology. Although the existence of morphogens is no longer in doubt, studies on the formation and function of their gradients have yielded...
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| Veröffentlicht in: | Cell 2007-01, Vol.128 (2), p.245-256 |
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| creator | Lander, Arthur D. |
| description | The theory that the spatial organization of cell fate is orchestrated by gradients of diffusing molecules was a major contribution to 20
th century developmental biology. Although the existence of morphogens is no longer in doubt, studies on the formation and function of their gradients have yielded far more puzzles than answers. On close inspection, every morphogen gradient seems to use a rich array of regulatory mechanisms, suggesting that the tasks carried out by such systems are far more extensive than previously thought. |
| doi_str_mv | 10.1016/j.cell.2007.01.004 |
| format | Article |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Body Patterning - physiology Diffusion Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Gene Expression Regulation, Developmental - physiology Humans Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Models, Biological Morphogenesis - physiology Signal Transduction - physiology Systems Biology - methods Systems Biology - trends |
| title | Morpheus Unbound: Reimagining the Morphogen Gradient |
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