A Rac-cGMP Signaling Pathway

The small GTPase Rac and the second messenger cGMP (guanosine 3′,5′-cyclic monophosphate) are critical regulators of diverse cell functions. When activated by extracellular signals via membrane signaling receptors, Rac executes its functions through engaging downstream effectors such as p21-activate...

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Veröffentlicht in:	Cell 2007-01, Vol.128 (2), p.341-355
Hauptverfasser:	Guo, Dagang, Tan, Ying-cai, Wang, Dawei, Madhusoodanan, K.S., Zheng, Yi, Maack, Thomas, Zhang, J. Jillian, Huang, Xin-Yun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Membrane - genetics Cell Membrane - metabolism Cell Movement - drug effects Cell Movement - physiology Cells, Cultured CHO Cells Cricetinae Cricetulus Cyclic GMP - metabolism Fibroblasts - drug effects Fibroblasts - metabolism Guanylate Cyclase - metabolism Humans Mice Mice, Knockout p21-Activated Kinases Platelet-Derived Growth Factor - metabolism Platelet-Derived Growth Factor - pharmacology Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Pseudopodia - drug effects Pseudopodia - metabolism rac GTP-Binding Proteins - metabolism Signal Transduction - drug effects Signal Transduction - physiology Up-Regulation - drug effects Up-Regulation - physiology
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