Role of ERK 1/2 signaling in neuronal differentiation of cultured embryonic stem cells

Embryonic stem (ES) cells represent an ideal source for cell engraftment in the damaged central nervous system (CNS). Understanding key signals that control ES cell differentiation may improve cell type‐specific differentiation that is suitable for transplantation therapy. We tested the hypothesis t...

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Veröffentlicht in:	Development, growth & differentiation growth & differentiation, 2006-10, Vol.48 (8), p.513-523
Hauptverfasser:	Li, Zegui, Theus, Michelle Hedrick, Wei, Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Cell Differentiation - drug effects Cell Differentiation - physiology Cell Line embryonic stem cell Embryonic Stem Cells - cytology Embryonic Stem Cells - physiology extracellular signal‐regulated kinase (ERK) phosphorylation growth factor MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Mice Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism neurite outgrowth neuronal differentiation Neurons - cytology Neurons - physiology Stem Cell Transplantation Tretinoin - pharmacology
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