Effect of tumor necrosis factor α on electrically induced calcium transients elicited in C2C12 skeletal myotubes
Diseases involving chronic inflammation can lead to prolonged exposure of skeletal muscle to inflammatory cytokines such as tumor necrosis factor α (TNFα), which may contribute to the skeletal muscle weakness seen in these conditions. In this study we examined the effect of a prolonged exposure to T...
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| Veröffentlicht in: | Muscle & nerve 2007-02, Vol.35 (2), p.251-253 |
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| creator | van Kann, Lisa N. Bakker, Anthony J. |
| description | Diseases involving chronic inflammation can lead to prolonged exposure of skeletal muscle to inflammatory cytokines such as tumor necrosis factor α (TNFα), which may contribute to the skeletal muscle weakness seen in these conditions. In this study we examined the effect of a prolonged exposure to TNFα on intracellular Ca2+ transients elicited in skeletal C2C12 myotubes. A 48‐h exposure to TNFα (10 ng/mL) significantly reduced the peaks, time to peak, and rate of Ca2+ decay of electrically induced Ca2+ transients elicited in C2C12 skeletal myotubes. TNFα exposure had no significant effect on the resting Ca2+ levels. The results of this study indicate that prolonged exposure to TNFα decreases sarcoplasmic reticulum Ca2+ release in cultured skeletal muscle cells. This altered Ca2+ release could contribute to the muscle weakness found in conditions involving chronic inflammation. Muscle Nerve, 2006 |
| doi_str_mv | 10.1002/mus.20635 |
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In this study we examined the effect of a prolonged exposure to TNFα on intracellular Ca2+ transients elicited in skeletal C2C12 myotubes. A 48‐h exposure to TNFα (10 ng/mL) significantly reduced the peaks, time to peak, and rate of Ca2+ decay of electrically induced Ca2+ transients elicited in C2C12 skeletal myotubes. TNFα exposure had no significant effect on the resting Ca2+ levels. The results of this study indicate that prolonged exposure to TNFα decreases sarcoplasmic reticulum Ca2+ release in cultured skeletal muscle cells. This altered Ca2+ release could contribute to the muscle weakness found in conditions involving chronic inflammation. Muscle Nerve, 2006</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.20635</identifier><identifier>PMID: 17195170</identifier><identifier>CODEN: MUNEDE</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Biological and medical sciences ; calcium ; Calcium - metabolism ; Cell Line, Transformed ; cytokines ; Drug toxicity and drugs side effects treatment ; Electric Stimulation ; Fundamental and applied biological sciences. Psychology ; inflammation ; Medical sciences ; Mice ; Myoblasts, Skeletal - drug effects ; Myoblasts, Skeletal - radiation effects ; Pharmacology. Drug treatments ; Reaction Time - drug effects ; Reaction Time - radiation effects ; sarcoplasmic reticulum ; skeletal muscle disease ; skeletal muscle weakness ; Striated muscle. Tendons ; TNFα ; Toxicity: nervous system and muscle ; tumor necrosis factor α ; Tumor Necrosis Factor-alpha - pharmacology ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>Muscle & nerve, 2007-02, Vol.35 (2), p.251-253</ispartof><rights>Copyright © 2006 Wiley Periodicals, Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.20635$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.20635$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18518045$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17195170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Kann, Lisa N.</creatorcontrib><creatorcontrib>Bakker, Anthony J.</creatorcontrib><title>Effect of tumor necrosis factor α on electrically induced calcium transients elicited in C2C12 skeletal myotubes</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>Diseases involving chronic inflammation can lead to prolonged exposure of skeletal muscle to inflammatory cytokines such as tumor necrosis factor α (TNFα), which may contribute to the skeletal muscle weakness seen in these conditions. In this study we examined the effect of a prolonged exposure to TNFα on intracellular Ca2+ transients elicited in skeletal C2C12 myotubes. A 48‐h exposure to TNFα (10 ng/mL) significantly reduced the peaks, time to peak, and rate of Ca2+ decay of electrically induced Ca2+ transients elicited in C2C12 skeletal myotubes. TNFα exposure had no significant effect on the resting Ca2+ levels. The results of this study indicate that prolonged exposure to TNFα decreases sarcoplasmic reticulum Ca2+ release in cultured skeletal muscle cells. This altered Ca2+ release could contribute to the muscle weakness found in conditions involving chronic inflammation. Muscle Nerve, 2006</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>calcium</subject><subject>Calcium - metabolism</subject><subject>Cell Line, Transformed</subject><subject>cytokines</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Electric Stimulation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>inflammation</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Myoblasts, Skeletal - drug effects</subject><subject>Myoblasts, Skeletal - radiation effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Reaction Time - drug effects</subject><subject>Reaction Time - radiation effects</subject><subject>sarcoplasmic reticulum</subject><subject>skeletal muscle disease</subject><subject>skeletal muscle weakness</subject><subject>Striated muscle. Tendons</subject><subject>TNFα</subject><subject>Toxicity: nervous system and muscle</subject><subject>tumor necrosis factor α</subject><subject>Tumor Necrosis Factor-alpha - pharmacology</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkctO5DAQRS0Egh6GBT-AvIFdwBXHjyyhxVMMMJrhITaW49iSIQ-IHQ39WfwI34She2BVVapzS7p1EdoEsguE5HvtGHZzwilbQhMgpcgKVsplNCFQyIzT8m4N_QjhgRACkotVtAYCSgaCTNDzoXPWRNw7HMe2H3BnzdAHH7DTJqb57RX3HbZNggZvdNPMsO_q0dgap8n4scVx0F3wtoshcd74mHa-w9N8CjkOj0kbdYPbWR_HyoafaMXpJtiNRV1H10eHf6cn2fnl8el0_zzzFATLQItkqWCm4o7mpATJODgiZA2y4iIvmXZVXVhjeF7zmpIih1pTw0VCuSF0He3M7z4N_fNoQ1StD8Y2je5sPwbFZVkUUkACtxbgWLW2Vk-Db_UwU_-flIDtBaBD8uySXePDNycZSFKwxO3NuX--sbPvPVEfKamUkvpMSf26_vPZJEU2V_gQ7cuXQg-PigsqmLq9OFYHN_dnv-9vbtUVfQeLnpRe</recordid><startdate>200702</startdate><enddate>200702</enddate><creator>van Kann, Lisa N.</creator><creator>Bakker, Anthony J.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200702</creationdate><title>Effect of tumor necrosis factor α on electrically induced calcium transients elicited in C2C12 skeletal myotubes</title><author>van Kann, Lisa N. ; Bakker, Anthony J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3175-1a720645cb6f320918561f078d18b67295afbd4ecc62d6d30421da3c679186c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>calcium</topic><topic>Calcium - metabolism</topic><topic>Cell Line, Transformed</topic><topic>cytokines</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Electric Stimulation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>inflammation</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Myoblasts, Skeletal - drug effects</topic><topic>Myoblasts, Skeletal - radiation effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Reaction Time - drug effects</topic><topic>Reaction Time - radiation effects</topic><topic>sarcoplasmic reticulum</topic><topic>skeletal muscle disease</topic><topic>skeletal muscle weakness</topic><topic>Striated muscle. Tendons</topic><topic>TNFα</topic><topic>Toxicity: nervous system and muscle</topic><topic>tumor necrosis factor α</topic><topic>Tumor Necrosis Factor-alpha - pharmacology</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Kann, Lisa N.</creatorcontrib><creatorcontrib>Bakker, Anthony J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Kann, Lisa N.</au><au>Bakker, Anthony J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of tumor necrosis factor α on electrically induced calcium transients elicited in C2C12 skeletal myotubes</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2007-02</date><risdate>2007</risdate><volume>35</volume><issue>2</issue><spage>251</spage><epage>253</epage><pages>251-253</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><coden>MUNEDE</coden><abstract>Diseases involving chronic inflammation can lead to prolonged exposure of skeletal muscle to inflammatory cytokines such as tumor necrosis factor α (TNFα), which may contribute to the skeletal muscle weakness seen in these conditions. In this study we examined the effect of a prolonged exposure to TNFα on intracellular Ca2+ transients elicited in skeletal C2C12 myotubes. A 48‐h exposure to TNFα (10 ng/mL) significantly reduced the peaks, time to peak, and rate of Ca2+ decay of electrically induced Ca2+ transients elicited in C2C12 skeletal myotubes. TNFα exposure had no significant effect on the resting Ca2+ levels. The results of this study indicate that prolonged exposure to TNFα decreases sarcoplasmic reticulum Ca2+ release in cultured skeletal muscle cells. This altered Ca2+ release could contribute to the muscle weakness found in conditions involving chronic inflammation. Muscle Nerve, 2006</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>17195170</pmid><doi>10.1002/mus.20635</doi><tpages>3</tpages></addata></record> |
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| ispartof | Muscle & nerve, 2007-02, Vol.35 (2), p.251-253 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Biological and medical sciences calcium Calcium - metabolism Cell Line, Transformed cytokines Drug toxicity and drugs side effects treatment Electric Stimulation Fundamental and applied biological sciences. Psychology inflammation Medical sciences Mice Myoblasts, Skeletal - drug effects Myoblasts, Skeletal - radiation effects Pharmacology. Drug treatments Reaction Time - drug effects Reaction Time - radiation effects sarcoplasmic reticulum skeletal muscle disease skeletal muscle weakness Striated muscle. Tendons TNFα Toxicity: nervous system and muscle tumor necrosis factor α Tumor Necrosis Factor-alpha - pharmacology Vertebrates: osteoarticular system, musculoskeletal system |
| title | Effect of tumor necrosis factor α on electrically induced calcium transients elicited in C2C12 skeletal myotubes |
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