Solid-State NMR Evidence for a Protonation Switch in the Binding Pocket of the H1 Receptor upon Binding of the Agonist Histamine

G protein coupled receptors (GPCRs) represent a major superfamily of transmembrane receptor proteins that are crucial in cellular signaling and are major pharmacological targets. While the activity of GPCRs can be modulated by agonist binding, the mechanisms that link agonist binding to G protein co...

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Veröffentlicht in:	Journal of the American Chemical Society 2007-01, Vol.129 (4), p.867-872
Hauptverfasser:	Ratnala, Venkata R. P, Kiihne, Suzanne R, Buda, Francesco, Leurs, Rob, de Groot, Huub J. M, DeGrip, Willem J
Format:	Artikel
Sprache:	eng
Schlagworte:	Histamine - pharmacology Histamine Agonists - pharmacology Humans Ligands Magnetic Resonance Spectroscopy - methods Protons Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - chemistry Receptors, Histamine H1 - chemistry Receptors, Histamine H1 - drug effects
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