WFS1 protein modulates the free Ca(2+) concentration in the endoplasmic reticulum

The WFS1 gene, encoding an endoplasmic reticulum (ER) membrane glycoprotein, is mutated in Wolfram syndrome characterized by diabetes mellitus and optic atrophy. Herein, Ca(2+) dynamics were examined in WFS1-knockdown and -overexpressing HEK293 cells. Studies using ER-targeted Ca(2+)-sensitive photo...

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Veröffentlicht in:	FEBS letters 2006-10, Vol.580 (24), p.5635-5640
Hauptverfasser:	Takei, Daisuke, Ishihara, Hisamitsu, Yamaguchi, Suguru, Yamada, Takahiro, Tamura, Akira, Katagiri, Hideki, Maruyama, Yoshio, Oka, Yoshitomo
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Calcium - metabolism Cell Line Endoplasmic Reticulum - metabolism Gene Expression Regulation Humans Membrane Proteins - genetics Membrane Proteins - metabolism Molecular Sequence Data RNA Interference
Online-Zugang:	Volltext
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