In vivo SPECT imaging of muscarinic acetylcholine receptors using ( R, R) 123I-QNB in dementia with Lewy bodies and Parkinson’s disease dementia

Alterations in cholinergic function have been reported to be associated with dementia. The aim of this study was to investigate differences in the distribution of muscarinic acetylcholine receptors (mAChRs) using ( R, R) 123I-iodo-quinuclidinyl-benzilate (QNB) and single photon emission computed tom...

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Veröffentlicht in:	NeuroImage (Orlando, Fla.) Fla.), 2006-11, Vol.33 (2), p.423-429
Hauptverfasser:	Colloby, Sean J., Pakrasi, Sanjeet, Firbank, Michael J., Perry, Elaine K., Piggott, Margaret A., Owens, Jonathan, Wyper, David J., McKeith, Ian G., Burn, David J., Williams, E. David, O’Brien, John T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Brain Brain research Cognition & reasoning Dementia Female Humans Image Processing, Computer-Assisted Inventory Iodine Radioisotopes Lewy Body Disease - diagnostic imaging Male Middle Aged Nuclear medicine Older people Parkinson Disease - diagnostic imaging Quinuclidinyl Benzilate - analogs & derivatives Quinuclidinyl Benzilate - chemical synthesis Reference Values Studies Technetium Tomography, Emission-Computed, Single-Photon
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