EFFECTS OF SHRIMP (MACROBRACIUM ROSENBERGII)-DERIVED CHITOSAN ON PLASMA LIPID PROFILE AND LIVER LIPID PEROXIDE LEVELS IN NORMO- AND HYPERCHOLESTEROLAEMIC RATS
SUMMARY 1 The effects of chitosan (CS) derived from the exoskeleton of the shrimp Macrobracium rosenbergii on bodyweight, plasma lipid profile, fatty acid composition, liver lipid peroxide (LPO) levels and plasma levels of glutamate pyruvate transaminase (GPT) were determined in normocholesterolaemi...
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| Veröffentlicht in: | Clinical and experimental pharmacology & physiology 2007-03, Vol.34 (3), p.170-176 |
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| creator | Hossain, Shahdat Rahman, Azizur Kabir, Yearul Shams, Ali Ahmed Afros, Fahmida Hashimoto, Michio |
| description | SUMMARY
1
The effects of chitosan (CS) derived from the exoskeleton of the shrimp Macrobracium rosenbergii on bodyweight, plasma lipid profile, fatty acid composition, liver lipid peroxide (LPO) levels and plasma levels of glutamate pyruvate transaminase (GPT) were determined in normocholesterolaemic (NC) and hypercholesterolaemic (HC) Long Evans rats.
2
The NC rats were fed a diet containing 2% CS and the HC rats were fed a diet containing 2 and 4% CS for 8 weeks. Chitosan significantly reduced bodyweight gain only in HC + 4% CS rats compared with HC rats, but not in NC + 2% CS or HC + 2% CS rats.
3
Chitosan reduced plasma total cholesterol in the HC + 2% CS, HC + 4% CS and NC + 2% CS rats; however, low density lipoprotein–cholesterol decreased only in the first two groups. High‐density lipoprotein–cholesterol (HDL‐C) increased in the HC + 4% CS rats by 24% compared with the HC + 2% CS group and by 30% compared with HC rats; however, HDL‐C did not increase in the NC + 2% CS group compared with NC rats. The level of plasma triglycerides decreased significantly only in HC + 2% CS rats compared with HC rats.
4
Chitosan significantly decreased plasma levels of arachidonic acid in the HC + 2% CS and HC + 4% CS groups, with a concurrent increase in the molar ratio of total unsaturated fatty acid (TUFA) to total saturated fatty acid (TSFA).
5
Moreover, CS increased liver LPO levels without affecting plasma levels of GPT. Liver LPO levels were positively correlated with the TUFA/TSFA molar ratio.
6
The present study suggests that dietary CS decreases the atherogenic lipid profiles of both NC and HC rats and reduces the bodyweight gain of HC rats. |
| doi_str_mv | 10.1111/j.1440-1681.2007.04568.x |
| format | Article |
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1
The effects of chitosan (CS) derived from the exoskeleton of the shrimp Macrobracium rosenbergii on bodyweight, plasma lipid profile, fatty acid composition, liver lipid peroxide (LPO) levels and plasma levels of glutamate pyruvate transaminase (GPT) were determined in normocholesterolaemic (NC) and hypercholesterolaemic (HC) Long Evans rats.
2
The NC rats were fed a diet containing 2% CS and the HC rats were fed a diet containing 2 and 4% CS for 8 weeks. Chitosan significantly reduced bodyweight gain only in HC + 4% CS rats compared with HC rats, but not in NC + 2% CS or HC + 2% CS rats.
3
Chitosan reduced plasma total cholesterol in the HC + 2% CS, HC + 4% CS and NC + 2% CS rats; however, low density lipoprotein–cholesterol decreased only in the first two groups. High‐density lipoprotein–cholesterol (HDL‐C) increased in the HC + 4% CS rats by 24% compared with the HC + 2% CS group and by 30% compared with HC rats; however, HDL‐C did not increase in the NC + 2% CS group compared with NC rats. The level of plasma triglycerides decreased significantly only in HC + 2% CS rats compared with HC rats.
4
Chitosan significantly decreased plasma levels of arachidonic acid in the HC + 2% CS and HC + 4% CS groups, with a concurrent increase in the molar ratio of total unsaturated fatty acid (TUFA) to total saturated fatty acid (TSFA).
5
Moreover, CS increased liver LPO levels without affecting plasma levels of GPT. Liver LPO levels were positively correlated with the TUFA/TSFA molar ratio.
6
The present study suggests that dietary CS decreases the atherogenic lipid profiles of both NC and HC rats and reduces the bodyweight gain of HC rats.</description><identifier>ISSN: 0305-1870</identifier><identifier>EISSN: 1440-1681</identifier><identifier>DOI: 10.1111/j.1440-1681.2007.04568.x</identifier><identifier>PMID: 17250635</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Alanine Transaminase - blood ; Animals ; Aspartate Aminotransferases - blood ; Body Weight - drug effects ; chitosan ; Chitosan - chemistry ; Chitosan - isolation & purification ; Chitosan - pharmacology ; Dealkylation ; Diet ; Eating - drug effects ; exoskeleton ; Fatty Acids - blood ; Female ; hypercholesterolaemia ; Hypercholesterolemia - blood ; Lipid Peroxides - blood ; lipids ; Lipids - blood ; Liver - drug effects ; Liver - metabolism ; Penaeidae - chemistry ; Rats ; Rats, Long-Evans ; shrimp</subject><ispartof>Clinical and experimental pharmacology & physiology, 2007-03, Vol.34 (3), p.170-176</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4718-b2af17a48c149036a116f9612d9ada445d0cd499c5c7cde80f1c843eaff416e3</citedby><cites>FETCH-LOGICAL-c4718-b2af17a48c149036a116f9612d9ada445d0cd499c5c7cde80f1c843eaff416e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1440-1681.2007.04568.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1440-1681.2007.04568.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17250635$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hossain, Shahdat</creatorcontrib><creatorcontrib>Rahman, Azizur</creatorcontrib><creatorcontrib>Kabir, Yearul</creatorcontrib><creatorcontrib>Shams, Ali Ahmed</creatorcontrib><creatorcontrib>Afros, Fahmida</creatorcontrib><creatorcontrib>Hashimoto, Michio</creatorcontrib><title>EFFECTS OF SHRIMP (MACROBRACIUM ROSENBERGII)-DERIVED CHITOSAN ON PLASMA LIPID PROFILE AND LIVER LIPID PEROXIDE LEVELS IN NORMO- AND HYPERCHOLESTEROLAEMIC RATS</title><title>Clinical and experimental pharmacology & physiology</title><addtitle>Clin Exp Pharmacol Physiol</addtitle><description>SUMMARY
1
The effects of chitosan (CS) derived from the exoskeleton of the shrimp Macrobracium rosenbergii on bodyweight, plasma lipid profile, fatty acid composition, liver lipid peroxide (LPO) levels and plasma levels of glutamate pyruvate transaminase (GPT) were determined in normocholesterolaemic (NC) and hypercholesterolaemic (HC) Long Evans rats.
2
The NC rats were fed a diet containing 2% CS and the HC rats were fed a diet containing 2 and 4% CS for 8 weeks. Chitosan significantly reduced bodyweight gain only in HC + 4% CS rats compared with HC rats, but not in NC + 2% CS or HC + 2% CS rats.
3
Chitosan reduced plasma total cholesterol in the HC + 2% CS, HC + 4% CS and NC + 2% CS rats; however, low density lipoprotein–cholesterol decreased only in the first two groups. High‐density lipoprotein–cholesterol (HDL‐C) increased in the HC + 4% CS rats by 24% compared with the HC + 2% CS group and by 30% compared with HC rats; however, HDL‐C did not increase in the NC + 2% CS group compared with NC rats. The level of plasma triglycerides decreased significantly only in HC + 2% CS rats compared with HC rats.
4
Chitosan significantly decreased plasma levels of arachidonic acid in the HC + 2% CS and HC + 4% CS groups, with a concurrent increase in the molar ratio of total unsaturated fatty acid (TUFA) to total saturated fatty acid (TSFA).
5
Moreover, CS increased liver LPO levels without affecting plasma levels of GPT. Liver LPO levels were positively correlated with the TUFA/TSFA molar ratio.
6
The present study suggests that dietary CS decreases the atherogenic lipid profiles of both NC and HC rats and reduces the bodyweight gain of HC rats.</description><subject>Alanine Transaminase - blood</subject><subject>Animals</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Body Weight - drug effects</subject><subject>chitosan</subject><subject>Chitosan - chemistry</subject><subject>Chitosan - isolation & purification</subject><subject>Chitosan - pharmacology</subject><subject>Dealkylation</subject><subject>Diet</subject><subject>Eating - drug effects</subject><subject>exoskeleton</subject><subject>Fatty Acids - blood</subject><subject>Female</subject><subject>hypercholesterolaemia</subject><subject>Hypercholesterolemia - blood</subject><subject>Lipid Peroxides - blood</subject><subject>lipids</subject><subject>Lipids - blood</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Penaeidae - chemistry</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><subject>shrimp</subject><issn>0305-1870</issn><issn>1440-1681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc2O0zAURi0EYsrAKyCvECwS7MT5W7BIE7ex5MSREwKsLE_iSC0tHZKppvMy86wk0zJs8cZX957v2tIBAGJk4-l83tqYEGRhP8S2g1BgI-L5oX16ARbPg5dggVzkWTgM0BV4M45bhJCHfPc1uMKBM1feAjzS1YomdQXFClaZZHkJP-ZxIsVSxgn7mkMpKlosqVwz9slKqWQNTWGSsVpUcQFFAUseV3kMOStZCkspVoxTGBfp1Gmo_NunUnxnKYWcNpRXkBWwEDIX1hOZ_ZjmSSY4reoJ5DHNWQJlXFdvwate70bz7nJfg3pF6ySzuFizJOZWSwIcWjeO7nGgSdhiEiHX1xj7feRjp4t0pwnxOtR2JIparw3azoSox21IXKP7nmDfuNfgw3nt7XD4fTTjndpvxtbsdvqXORxH5YcRcYgfTGB4BtvhMI6D6dXtsNnr4UFhpGY1aqtmA2o2oGY16kmNOk3R95c3jjd70_0LXlxMwJczcL_ZmYf_XqwSWs7VlLfO-c14Z07PeT38VNPPA099K9YqCxre5IGrlu4fHR6fXw</recordid><startdate>200703</startdate><enddate>200703</enddate><creator>Hossain, Shahdat</creator><creator>Rahman, Azizur</creator><creator>Kabir, Yearul</creator><creator>Shams, Ali Ahmed</creator><creator>Afros, Fahmida</creator><creator>Hashimoto, Michio</creator><general>Blackwell Publishing Asia</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200703</creationdate><title>EFFECTS OF SHRIMP (MACROBRACIUM ROSENBERGII)-DERIVED CHITOSAN ON PLASMA LIPID PROFILE AND LIVER LIPID PEROXIDE LEVELS IN NORMO- AND HYPERCHOLESTEROLAEMIC RATS</title><author>Hossain, Shahdat ; Rahman, Azizur ; Kabir, Yearul ; Shams, Ali Ahmed ; Afros, Fahmida ; Hashimoto, Michio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4718-b2af17a48c149036a116f9612d9ada445d0cd499c5c7cde80f1c843eaff416e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Alanine Transaminase - blood</topic><topic>Animals</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Body Weight - drug effects</topic><topic>chitosan</topic><topic>Chitosan - chemistry</topic><topic>Chitosan - isolation & purification</topic><topic>Chitosan - pharmacology</topic><topic>Dealkylation</topic><topic>Diet</topic><topic>Eating - drug effects</topic><topic>exoskeleton</topic><topic>Fatty Acids - blood</topic><topic>Female</topic><topic>hypercholesterolaemia</topic><topic>Hypercholesterolemia - blood</topic><topic>Lipid Peroxides - blood</topic><topic>lipids</topic><topic>Lipids - blood</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Penaeidae - chemistry</topic><topic>Rats</topic><topic>Rats, Long-Evans</topic><topic>shrimp</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hossain, Shahdat</creatorcontrib><creatorcontrib>Rahman, Azizur</creatorcontrib><creatorcontrib>Kabir, Yearul</creatorcontrib><creatorcontrib>Shams, Ali Ahmed</creatorcontrib><creatorcontrib>Afros, Fahmida</creatorcontrib><creatorcontrib>Hashimoto, Michio</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental pharmacology & physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hossain, Shahdat</au><au>Rahman, Azizur</au><au>Kabir, Yearul</au><au>Shams, Ali Ahmed</au><au>Afros, Fahmida</au><au>Hashimoto, Michio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECTS OF SHRIMP (MACROBRACIUM ROSENBERGII)-DERIVED CHITOSAN ON PLASMA LIPID PROFILE AND LIVER LIPID PEROXIDE LEVELS IN NORMO- AND HYPERCHOLESTEROLAEMIC RATS</atitle><jtitle>Clinical and experimental pharmacology & physiology</jtitle><addtitle>Clin Exp Pharmacol Physiol</addtitle><date>2007-03</date><risdate>2007</risdate><volume>34</volume><issue>3</issue><spage>170</spage><epage>176</epage><pages>170-176</pages><issn>0305-1870</issn><eissn>1440-1681</eissn><abstract>SUMMARY
1
The effects of chitosan (CS) derived from the exoskeleton of the shrimp Macrobracium rosenbergii on bodyweight, plasma lipid profile, fatty acid composition, liver lipid peroxide (LPO) levels and plasma levels of glutamate pyruvate transaminase (GPT) were determined in normocholesterolaemic (NC) and hypercholesterolaemic (HC) Long Evans rats.
2
The NC rats were fed a diet containing 2% CS and the HC rats were fed a diet containing 2 and 4% CS for 8 weeks. Chitosan significantly reduced bodyweight gain only in HC + 4% CS rats compared with HC rats, but not in NC + 2% CS or HC + 2% CS rats.
3
Chitosan reduced plasma total cholesterol in the HC + 2% CS, HC + 4% CS and NC + 2% CS rats; however, low density lipoprotein–cholesterol decreased only in the first two groups. High‐density lipoprotein–cholesterol (HDL‐C) increased in the HC + 4% CS rats by 24% compared with the HC + 2% CS group and by 30% compared with HC rats; however, HDL‐C did not increase in the NC + 2% CS group compared with NC rats. The level of plasma triglycerides decreased significantly only in HC + 2% CS rats compared with HC rats.
4
Chitosan significantly decreased plasma levels of arachidonic acid in the HC + 2% CS and HC + 4% CS groups, with a concurrent increase in the molar ratio of total unsaturated fatty acid (TUFA) to total saturated fatty acid (TSFA).
5
Moreover, CS increased liver LPO levels without affecting plasma levels of GPT. Liver LPO levels were positively correlated with the TUFA/TSFA molar ratio.
6
The present study suggests that dietary CS decreases the atherogenic lipid profiles of both NC and HC rats and reduces the bodyweight gain of HC rats.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>17250635</pmid><doi>10.1111/j.1440-1681.2007.04568.x</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Clinical and experimental pharmacology & physiology, 2007-03, Vol.34 (3), p.170-176 |
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| source | MEDLINE; Wiley Journals |
| subjects | Alanine Transaminase - blood Animals Aspartate Aminotransferases - blood Body Weight - drug effects chitosan Chitosan - chemistry Chitosan - isolation & purification Chitosan - pharmacology Dealkylation Diet Eating - drug effects exoskeleton Fatty Acids - blood Female hypercholesterolaemia Hypercholesterolemia - blood Lipid Peroxides - blood lipids Lipids - blood Liver - drug effects Liver - metabolism Penaeidae - chemistry Rats Rats, Long-Evans shrimp |
| title | EFFECTS OF SHRIMP (MACROBRACIUM ROSENBERGII)-DERIVED CHITOSAN ON PLASMA LIPID PROFILE AND LIVER LIPID PEROXIDE LEVELS IN NORMO- AND HYPERCHOLESTEROLAEMIC RATS |
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