Tramadol has a better potency ratio relative to morphine in neuropathic than in nociceptive pain models

Treatment of neuropathic pain remains a challenge and the role of various analgesics in this setting is still debated. The effects of tramadol, an atypically acting analgesic with a combined opioid and monoaminergic mechanism of action, and morphine, a prototypical opioid, were tested in rat models...

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Veröffentlicht in:	Drugs in R&D 2007, Vol.8 (1), p.51-57
Hauptverfasser:	Christoph, Thomas, Kögel, Babette, Strassburger, Wolfgang, Schug, Stephan A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - administration & dosage Analgesics, Opioid - pharmacology Animals Cold Temperature - adverse effects Disease Models, Animal Dose-Response Relationship, Drug Hot Temperature - adverse effects Hyperalgesia - drug therapy Hyperalgesia - physiopathology Injections, Intravenous Male Morphine - administration & dosage Morphine - pharmacology Pain - drug therapy Pain - etiology Pain Measurement - methods Rats Rats, Sprague-Dawley Sciatic Nerve - injuries Sciatic Neuropathy - drug therapy Sciatic Neuropathy - etiology Sciatic Neuropathy - physiopathology Time Factors Tramadol - administration & dosage Tramadol - pharmacology
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