Effects of alpha1D-adrenergic receptors on shedding of biologically active EGF in freshly isolated lacrimal gland epithelial cells

Transactivation of EGF receptors by G protein-coupled receptors is a well-known phenomenon. This process involves the ectodomain shedding of growth factors in the EGF family by matrix metalloproteinases. However, many of these studies employ transformed and/or cultured cells that overexpress labeled...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2006-11, Vol.291 (5), p.C946-C956
Hauptverfasser:	Chen, LiLi, Hodges, Robin R, Funaki, Chika, Zoukhri, Driss, Gaivin, Robert J, Perez, Dianne M, Dartt, Darlene A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-1 Receptor Agonists Adrenergic alpha-1 Receptor Antagonists Animals Binding, Competitive - drug effects Cell Separation - methods Culture Media, Conditioned Enzyme Activation - drug effects Epidermal Growth Factor - metabolism Epidermal Growth Factor - pharmacology Epidermal Growth Factor - secretion Epithelial Cells - drug effects Epithelial Cells - secretion Lacrimal Apparatus - cytology Male Matrix Metalloproteinase Inhibitors Mitogen-Activated Protein Kinase 3 - metabolism Phenylephrine - pharmacology Rats Rats, Sprague-Dawley Receptor, Epidermal Growth Factor - metabolism Receptors, Adrenergic, alpha-1 - genetics Receptors, Adrenergic, alpha-1 - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Transcriptional Activation - drug effects
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