Discovery of galectin ligands in fully randomized combinatorial one-bead-one-compound (glyco)peptide libraries

Human lectins (galectins) are emerging targets for drug design. Combinatorial one-bead-one-compound (glyco)peptide libraries were screened with galectin-1 and -3. Testing lead (glyco)peptides includes medically relevant inhibition assays with tumour cells. The involvement of human lectins (galectins...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-02, Vol.17 (3), p.793-798
Hauptverfasser:	André, Sabine, Maljaars, C. Elizabeth P., Halkes, Koen M., Gabius, Hans-Joachim, Kamerling, Johannis P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Line, Tumor Combinatorial (glyco)peptide libraries Combinatorial Chemistry Techniques Galectins Galectins - chemistry Glycopeptides - chemical synthesis Glycopeptides - pharmacology Humans Indicators and Reagents Ligands Medical sciences Miscellaneous Peptide Library Pharmacology. Drug treatments
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