Sensory Cilia and Integration of Signal Transduction in Human Health and Disease
The primary cilium is a hallmark of mammalian tissue cells. Recent research has shown that these organelles display unique sets of selected signal transduction modules including receptors, ion channels, effector proteins and transcription factors that relay chemical and physical stimuli from the ext...
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| Veröffentlicht in: | Traffic (Copenhagen, Denmark) Denmark), 2007-02, Vol.8 (2), p.97-109 |
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| creator | Christensen, Søren T. Pedersen, Lotte B. Schneider, Linda Satir, Peter |
| description | The primary cilium is a hallmark of mammalian tissue cells. Recent research has shown that these organelles display unique sets of selected signal transduction modules including receptors, ion channels, effector proteins and transcription factors that relay chemical and physical stimuli from the extracellular environment in order to control basic cellular processes during embryonic and postnatal development, as well as in tissue homeostasis in adulthood. Consequently, defects in building of the cilium or in transport or function of ciliary signal proteins are associated with a series of pathologies, including developmental disorders and cancer. In this review, we highlight recent examples of the mechanisms by which signal components are selectively targeted and transported to the ciliary membrane and we present an overview of the signal transduction pathways associated with primary and motile cilia in vertebrate cells, including platelet‐derived growth factor receptor‐alpha (PDGFRα), hedgehog and Wnt signaling pathways. Finally, we discuss the functions of these cilia‐associated signal transduction pathways and their role in human health and development. |
| doi_str_mv | 10.1111/j.1600-0854.2006.00516.x |
| format | Article |
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Finally, we discuss the functions of these cilia‐associated signal transduction pathways and their role in human health and development.</description><subject>Animals</subject><subject>cell survival</subject><subject>centrioles</subject><subject>centrosomes</subject><subject>Cilia - metabolism</subject><subject>development</subject><subject>differentiation</subject><subject>Disease</subject><subject>growth control</subject><subject>Health</subject><subject>Hedgehog Proteins - metabolism</subject><subject>Humans</subject><subject>IFT</subject><subject>Membrane Proteins - metabolism</subject><subject>migration</subject><subject>motile cilia</subject><subject>pathology</subject><subject>patterning</subject><subject>primary cilia</subject><subject>Protein Transport</subject><subject>Receptor, Platelet-Derived Growth Factor alpha - metabolism</subject><subject>sensory organelles</subject><subject>Signal Transduction</subject><subject>tissue homeostasis</subject><subject>Wnt Proteins - metabolism</subject><issn>1398-9219</issn><issn>1600-0854</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1PwzAMhiMEYmPwF1BO3Fry2aYSl2l8bNIkEBvnKE3TkalNR7KK7d_TbhNc8cG27Pe1pQcAiFGMu7hfxzhBKEKCs5gglMQIcZzEuzMw_F2cdz3NRJQRnA3AVQhrhBDhjF2CAU4Jw4yxIXhbGBcav4cTW1kFlSvgzG3NyqutbRxsSriwK6cquPTKhaLVh7F1cNrWqstGVdvPg-3RBqOCuQYXpaqCuTnVEfh4flpOptH89WU2Gc8jzQQhEaOaUkV5UiRpSsuM5BgXptSJLoQQWqUlViw3IqMoz43WRKMU5wxpzrKUUkNH4O54d-Obr9aEraxt0KaqlDNNG2QiMoY55p1QHIXaNyF4U8qNt7Xye4mR7GnKteyhyR6a7GnKA02566y3px9tXpviz3jC1wkejoJvW5n9vw_L5fuYp4T-AAsFgnE</recordid><startdate>200702</startdate><enddate>200702</enddate><creator>Christensen, Søren T.</creator><creator>Pedersen, Lotte B.</creator><creator>Schneider, Linda</creator><creator>Satir, Peter</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200702</creationdate><title>Sensory Cilia and Integration of Signal Transduction in Human Health and Disease</title><author>Christensen, Søren T. ; Pedersen, Lotte B. ; Schneider, Linda ; Satir, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4822-43c33a356d6773f92b11defc6cd888ca7f1a4be8930bbecc2c071b40c549733e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>cell survival</topic><topic>centrioles</topic><topic>centrosomes</topic><topic>Cilia - metabolism</topic><topic>development</topic><topic>differentiation</topic><topic>Disease</topic><topic>growth control</topic><topic>Health</topic><topic>Hedgehog Proteins - metabolism</topic><topic>Humans</topic><topic>IFT</topic><topic>Membrane Proteins - metabolism</topic><topic>migration</topic><topic>motile cilia</topic><topic>pathology</topic><topic>patterning</topic><topic>primary cilia</topic><topic>Protein Transport</topic><topic>Receptor, Platelet-Derived Growth Factor alpha - metabolism</topic><topic>sensory organelles</topic><topic>Signal Transduction</topic><topic>tissue homeostasis</topic><topic>Wnt Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Christensen, Søren T.</creatorcontrib><creatorcontrib>Pedersen, Lotte B.</creatorcontrib><creatorcontrib>Schneider, Linda</creatorcontrib><creatorcontrib>Satir, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Traffic (Copenhagen, Denmark)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Christensen, Søren T.</au><au>Pedersen, Lotte B.</au><au>Schneider, Linda</au><au>Satir, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sensory Cilia and Integration of Signal Transduction in Human Health and Disease</atitle><jtitle>Traffic (Copenhagen, Denmark)</jtitle><addtitle>Traffic</addtitle><date>2007-02</date><risdate>2007</risdate><volume>8</volume><issue>2</issue><spage>97</spage><epage>109</epage><pages>97-109</pages><issn>1398-9219</issn><eissn>1600-0854</eissn><abstract>The primary cilium is a hallmark of mammalian tissue cells. 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| ispartof | Traffic (Copenhagen, Denmark), 2007-02, Vol.8 (2), p.97-109 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Free Content; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals cell survival centrioles centrosomes Cilia - metabolism development differentiation Disease growth control Health Hedgehog Proteins - metabolism Humans IFT Membrane Proteins - metabolism migration motile cilia pathology patterning primary cilia Protein Transport Receptor, Platelet-Derived Growth Factor alpha - metabolism sensory organelles Signal Transduction tissue homeostasis Wnt Proteins - metabolism |
| title | Sensory Cilia and Integration of Signal Transduction in Human Health and Disease |
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