Human C5aR knock-in mice facilitate the production and assessment of anti-inflammatory monoclonal antibodies

Complement component C5a binds C5a receptor (C5aR) and facilitates leukocyte chemotaxis and release of inflammatory mediators. We used neutrophils from human C5aR knock-in mice, in which the mouse C5aR coding region was replaced with that of human C5aR, to immunize wild-type mice and to generate hig...

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Veröffentlicht in:	Nature biotechnology 2006-10, Vol.24 (10), p.1279-1284
Hauptverfasser:	Lee, Hyun, Zahra, David, Vogelzang, Alexis, Newton, Rebecca, Thatcher, Jenny, Quan, Annie, So, Trina, Zwirner, Jörg, Koentgen, Frank, Padkjær, Søren B, Mackay, Fabienne, Whitfeld, Peter L, Mackay, Charles R
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Binding sites Biochemistry Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Epitopes - immunology Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Humans Immunization Industrial applications and implications. Economical aspects Inflammation - drug therapy Inflammation - immunology letter Life Sciences Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Monoclonal antibodies Neutrophils - immunology Pharmacology Production of active biomolecules Receptor, Anaphylatoxin C5a Receptors, Complement - genetics Receptors, Complement - metabolism Rodents
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