Novel pyrazolopiperazinone- and pyrrolopiperazinone-based MCH-R1 antagonists

The synthesis and biological testing of novel classes of potent melanin-concentrating hormone (MCH-R1) antagonists based on pyrazolopiperazinone and pyrrolopiperazinone scaffolds are described. The synthesis and biological testing of novel classes of potent melanin-concentrating hormone (MCH-R1) ant...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-02, Vol.17 (3), p.657-661
Hauptverfasser:	Meyers, Kenneth M., Méndez-Andino, José, Colson, Anny-Odile, Hu, X. Eric, Wos, John A., Mitchell, Maria C., Hodge, Karen, Howard, Jeremy, Paris, Jennifer L., Dowty, Martin E., Obringer, Cindy M., Reizes, Ofer
Format:	Artikel
Sprache:	eng
Schlagworte:	5HT-2C receptor Biological and medical sciences Caco-2 Cells General and cellular metabolism. Vitamins Hormones. Endocrine system Humans Indicators and Reagents MCH-R1 antagonists Medical sciences Melanin-concentrating hormone Models, Molecular Molecular Conformation Obesity Pharmacology. Drug treatments Piperazines - chemical synthesis Piperazines - pharmacology Pyrazoles - chemical synthesis Pyrazoles - pharmacology Pyrazolopiperazinone Pyrroles - chemical synthesis Pyrroles - pharmacology Pyrrolopiperazinone Radioligand Assay Receptor, Serotonin, 5-HT2C - drug effects Receptors, Somatostatin - antagonists & inhibitors
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Zusammenfassung:	The synthesis and biological testing of novel classes of potent melanin-concentrating hormone (MCH-R1) antagonists based on pyrazolopiperazinone and pyrrolopiperazinone scaffolds are described. The synthesis and biological testing of novel classes of potent melanin-concentrating hormone (MCH-R1) antagonists based on pyrazolopiperazinone and pyrrolopiperazinone scaffolds are described.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2006.10.096