Cephalosporin resistance in Klebsiella pneumoniae from Nova Scotia, Canada
From 2116 Klebsiella pneumoniae strains isolated between January 2001 and December 2002 in Nova Scotia, Canada, 25 (1.18%) showed a reduced susceptibility to cefoxitin or extended-spectrum cephalosporins. Narrow-spectrum β-lactamase genes ( bla SHV-11, bla SHV-1, bla SHV-26, bla SHV-32, bla SHV-36,...
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| Veröffentlicht in: | Diagnostic microbiology and infectious disease 2006-10, Vol.56 (2), p.197-205 |
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| creator | Melano, Roberto G. Davidson, Ross J. Musgrave, Heather L. Forward, Kevin R. |
| description | From 2116
Klebsiella pneumoniae strains isolated between January 2001 and December 2002 in Nova Scotia, Canada, 25 (1.18%) showed a reduced susceptibility to cefoxitin or extended-spectrum cephalosporins. Narrow-spectrum β-lactamase genes (
bla
SHV-11,
bla
SHV-1,
bla
SHV-26,
bla
SHV-32,
bla
SHV-36, and
bla
SHV-40) were the most prevalent. Four new variants were identified (
bla
LEN-17,
bla
OKP-B-13,
bla
OKP-B-14, and
bla
OKP-A-11), representing the 1st description of
bla
OKP in the Americas. Among the extended-spectrum β-lactamase (ESBL) genes,
bla
SHV-2,
bla
SHV2a,
bla
SHV-12, and
bla
CTX-M-15 were detected (ESBL prevalence of 0.14%). Nineteen strains were resistant to cefoxitin (MIC, 32 to >256 μg/mL). Nevertheless, an AmpC-like activity was detected in only 1 strain, which expressed CMY-2. The combined effects of narrow-spectrum β-lactamase production and decreased or nonexpression of OmpK35/36 porins did not account for the cefoxitin resistance observed in some of these strains. |
| doi_str_mv | 10.1016/j.diagmicrobio.2006.04.016 |
| format | Article |
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Klebsiella pneumoniae strains isolated between January 2001 and December 2002 in Nova Scotia, Canada, 25 (1.18%) showed a reduced susceptibility to cefoxitin or extended-spectrum cephalosporins. Narrow-spectrum β-lactamase genes (
bla
SHV-11,
bla
SHV-1,
bla
SHV-26,
bla
SHV-32,
bla
SHV-36, and
bla
SHV-40) were the most prevalent. Four new variants were identified (
bla
LEN-17,
bla
OKP-B-13,
bla
OKP-B-14, and
bla
OKP-A-11), representing the 1st description of
bla
OKP in the Americas. Among the extended-spectrum β-lactamase (ESBL) genes,
bla
SHV-2,
bla
SHV2a,
bla
SHV-12, and
bla
CTX-M-15 were detected (ESBL prevalence of 0.14%). Nineteen strains were resistant to cefoxitin (MIC, 32 to >256 μg/mL). Nevertheless, an AmpC-like activity was detected in only 1 strain, which expressed CMY-2. The combined effects of narrow-spectrum β-lactamase production and decreased or nonexpression of OmpK35/36 porins did not account for the cefoxitin resistance observed in some of these strains.</description><identifier>ISSN: 0732-8893</identifier><identifier>EISSN: 1879-0070</identifier><identifier>DOI: 10.1016/j.diagmicrobio.2006.04.016</identifier><identifier>PMID: 16769193</identifier><identifier>CODEN: DMIDDZ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Amp-C ; Anti-Bacterial Agents - pharmacology ; Bacterial Proteins - chemistry ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; Bacteriology ; Biological and medical sciences ; Cephalosporin ; Cephalosporin Resistance ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Bacterial ; Humans ; Infectious diseases ; Klebsiella Infections - epidemiology ; Klebsiella Infections - microbiology ; Klebsiella pneumoniae ; Klebsiella pneumoniae - drug effects ; Klebsiella pneumoniae - genetics ; Medical sciences ; Microbial Sensitivity Tests ; Microbiology ; Miscellaneous ; Molecular Sequence Data ; Nova Scotia - epidemiology ; Outer brain protein ; Phylogeny</subject><ispartof>Diagnostic microbiology and infectious disease, 2006-10, Vol.56 (2), p.197-205</ispartof><rights>2006 Elsevier Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-b8bb93a57c21028a55c724d779f762dcee3ffe21ff4a431858d151d6b99ce0f23</citedby><cites>FETCH-LOGICAL-c439t-b8bb93a57c21028a55c724d779f762dcee3ffe21ff4a431858d151d6b99ce0f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0732889306001702$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18225232$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16769193$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Melano, Roberto G.</creatorcontrib><creatorcontrib>Davidson, Ross J.</creatorcontrib><creatorcontrib>Musgrave, Heather L.</creatorcontrib><creatorcontrib>Forward, Kevin R.</creatorcontrib><title>Cephalosporin resistance in Klebsiella pneumoniae from Nova Scotia, Canada</title><title>Diagnostic microbiology and infectious disease</title><addtitle>Diagn Microbiol Infect Dis</addtitle><description>From 2116
Klebsiella pneumoniae strains isolated between January 2001 and December 2002 in Nova Scotia, Canada, 25 (1.18%) showed a reduced susceptibility to cefoxitin or extended-spectrum cephalosporins. Narrow-spectrum β-lactamase genes (
bla
SHV-11,
bla
SHV-1,
bla
SHV-26,
bla
SHV-32,
bla
SHV-36, and
bla
SHV-40) were the most prevalent. Four new variants were identified (
bla
LEN-17,
bla
OKP-B-13,
bla
OKP-B-14, and
bla
OKP-A-11), representing the 1st description of
bla
OKP in the Americas. Among the extended-spectrum β-lactamase (ESBL) genes,
bla
SHV-2,
bla
SHV2a,
bla
SHV-12, and
bla
CTX-M-15 were detected (ESBL prevalence of 0.14%). Nineteen strains were resistant to cefoxitin (MIC, 32 to >256 μg/mL). Nevertheless, an AmpC-like activity was detected in only 1 strain, which expressed CMY-2. The combined effects of narrow-spectrum β-lactamase production and decreased or nonexpression of OmpK35/36 porins did not account for the cefoxitin resistance observed in some of these strains.</description><subject>Amino Acid Sequence</subject><subject>Amp-C</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacterial Proteins - chemistry</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacterial Proteins - metabolism</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Cephalosporin</subject><subject>Cephalosporin Resistance</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Bacterial</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Klebsiella Infections - epidemiology</subject><subject>Klebsiella Infections - microbiology</subject><subject>Klebsiella pneumoniae</subject><subject>Klebsiella pneumoniae - drug effects</subject><subject>Klebsiella pneumoniae - genetics</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Molecular Sequence Data</subject><subject>Nova Scotia - epidemiology</subject><subject>Outer brain protein</subject><subject>Phylogeny</subject><issn>0732-8893</issn><issn>1879-0070</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAQgC0EotvCX0AREj2R4EcS29zQlvKq4ACcrYk9Bq-SONjZSvx7vNqVyq09WaP5ZjzzDSEvGW0YZf2bXeMC_JqCTXEIseGU9g1tm5J6RDZMSV1TKuljsqFS8FopLc7Iec47ShnXLX1Kzlgve8202JDPW1x-wxjzElOYq4Q55BVmi1WJvow45IDjCNUy436KcwCsfIpT9TXeQvXdxjXA62oLMzh4Rp54GDM-P70X5Of1-x_bj_XNtw-ftu9uatsKvdaDGgYtoJOWM8oVdJ2VvHVSai977iyi8B45876FVjDVKcc65vpBa4vUc3FBLo99lxT_7DGvZgrZHqacMe6z6VVZUgl5L1gEtF2hC_j2CBajOSf0ZklhgvTXMGoOys3O_K_cHJQb2pqSKsUvTr_shwndXenJcQFenQDIFkafit6Q7zjFecfFYa-rI4dF3m3AZLINWE7hQkK7GhfDQ-b5B1uOphs</recordid><startdate>20061001</startdate><enddate>20061001</enddate><creator>Melano, Roberto G.</creator><creator>Davidson, Ross J.</creator><creator>Musgrave, Heather L.</creator><creator>Forward, Kevin R.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20061001</creationdate><title>Cephalosporin resistance in Klebsiella pneumoniae from Nova Scotia, Canada</title><author>Melano, Roberto G. ; Davidson, Ross J. ; Musgrave, Heather L. ; Forward, Kevin R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-b8bb93a57c21028a55c724d779f762dcee3ffe21ff4a431858d151d6b99ce0f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Amino Acid Sequence</topic><topic>Amp-C</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bacterial Proteins - chemistry</topic><topic>Bacterial Proteins - genetics</topic><topic>Bacterial Proteins - metabolism</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Cephalosporin</topic><topic>Cephalosporin Resistance</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation, Bacterial</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Klebsiella Infections - epidemiology</topic><topic>Klebsiella Infections - microbiology</topic><topic>Klebsiella pneumoniae</topic><topic>Klebsiella pneumoniae - drug effects</topic><topic>Klebsiella pneumoniae - genetics</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Molecular Sequence Data</topic><topic>Nova Scotia - epidemiology</topic><topic>Outer brain protein</topic><topic>Phylogeny</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Melano, Roberto G.</creatorcontrib><creatorcontrib>Davidson, Ross J.</creatorcontrib><creatorcontrib>Musgrave, Heather L.</creatorcontrib><creatorcontrib>Forward, Kevin R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Diagnostic microbiology and infectious disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Melano, Roberto G.</au><au>Davidson, Ross J.</au><au>Musgrave, Heather L.</au><au>Forward, Kevin R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cephalosporin resistance in Klebsiella pneumoniae from Nova Scotia, Canada</atitle><jtitle>Diagnostic microbiology and infectious disease</jtitle><addtitle>Diagn Microbiol Infect Dis</addtitle><date>2006-10-01</date><risdate>2006</risdate><volume>56</volume><issue>2</issue><spage>197</spage><epage>205</epage><pages>197-205</pages><issn>0732-8893</issn><eissn>1879-0070</eissn><coden>DMIDDZ</coden><abstract>From 2116
Klebsiella pneumoniae strains isolated between January 2001 and December 2002 in Nova Scotia, Canada, 25 (1.18%) showed a reduced susceptibility to cefoxitin or extended-spectrum cephalosporins. Narrow-spectrum β-lactamase genes (
bla
SHV-11,
bla
SHV-1,
bla
SHV-26,
bla
SHV-32,
bla
SHV-36, and
bla
SHV-40) were the most prevalent. Four new variants were identified (
bla
LEN-17,
bla
OKP-B-13,
bla
OKP-B-14, and
bla
OKP-A-11), representing the 1st description of
bla
OKP in the Americas. Among the extended-spectrum β-lactamase (ESBL) genes,
bla
SHV-2,
bla
SHV2a,
bla
SHV-12, and
bla
CTX-M-15 were detected (ESBL prevalence of 0.14%). Nineteen strains were resistant to cefoxitin (MIC, 32 to >256 μg/mL). Nevertheless, an AmpC-like activity was detected in only 1 strain, which expressed CMY-2. The combined effects of narrow-spectrum β-lactamase production and decreased or nonexpression of OmpK35/36 porins did not account for the cefoxitin resistance observed in some of these strains.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16769193</pmid><doi>10.1016/j.diagmicrobio.2006.04.016</doi><tpages>9</tpages></addata></record> |
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| subjects | Amino Acid Sequence Amp-C Anti-Bacterial Agents - pharmacology Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Biological and medical sciences Cephalosporin Cephalosporin Resistance Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Bacterial Humans Infectious diseases Klebsiella Infections - epidemiology Klebsiella Infections - microbiology Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - genetics Medical sciences Microbial Sensitivity Tests Microbiology Miscellaneous Molecular Sequence Data Nova Scotia - epidemiology Outer brain protein Phylogeny |
| title | Cephalosporin resistance in Klebsiella pneumoniae from Nova Scotia, Canada |
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