Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors

We have characterized a novel binding mode for a newly discovered 2,4-disubstituted pyrimidine inhibitor of AIK, using X-ray crystallography. This structure provides an excellent basis for the design of specific and potent compounds with potential therapeutic value in the treatment of cancer. The 2....

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