Bimodal actions of reactive oxygen species in the differentiation and bone-resorbing functions of osteoclasts

In order to demonstrate that cellular redox status undergoes decreased reduction during osteoclast differentiation and further decreased reduction during osteoclastic bone resorption, we analyzed γ-glutamylcysteinyl synthetase activity, a glutathione synthesis rate-limiting enzyme, and total glutath...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	FEBS letters 2006-10, Vol.580 (24), p.5661-5665
Hauptverfasser:	Kim, Hyunsoo, Kim, Ick Young, Lee, Soo Young, Jeong, Daewon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BMMs Bone Marrow Cells - cytology bone marrow-derived monocytes Bone resorption Bone Resorption - metabolism BSO Cell Differentiation Cells, Cultured Glutathione GSH H2O2 hydrogen peroxide l-buthionine-(S,R)-sulfoximine M-CSF macrophage colony-stimulating factor Macrophages - cytology Mice Monocytes - cytology N-acetylcysteine NAC Osteoclast differentiation Osteoclasts - cytology Osteoclasts - metabolism Oxidation-Reduction RANKL Reactive oxygen species Reactive Oxygen Species - metabolism receptor activator of NF-κB ligand Redox status ROS tartrate-resistant acid phosphatase(+) multi-nucleated cells TRAP(+) MNCs γ-GCS γ-glutamylcysteinyl synthetase
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!