8‐Hydroxy‐2′‐deoxyguanosine (8‐OH‐dG) as a potential survival biomarker in patients with nonsmall‐cell lung cancer

BACKGROUND. 8‐Hydroxy‐2′‐deoxyguanosine (8‐OH‐dG) is 1 of the most abundant oxidative products of cellular DNA. Accumulation of impaired 8‐OH‐dG could lead to increased genomic instability that in turn could lead to a more malignant phenotypic behavior of tumors. Therefore, the effects of 8‐OH‐dG on...

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Veröffentlicht in:	Cancer 2007-02, Vol.109 (3), p.574-580
Hauptverfasser:	Shen, Jie, Deininger, Prescott, Hunt, Jay D., Zhao, Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	8‐OH‐dG base excision repair Biological and medical sciences Biomarkers, Tumor - metabolism Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - mortality Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism DNA Damage DNA Glycosylases - genetics DNA Glycosylases - metabolism DNA Repair DNA, Neoplasm - metabolism Enzyme-Linked Immunosorbent Assay Female Genotype hOGG1 polymorphism Humans lung cancer Lung Neoplasms - genetics Lung Neoplasms - mortality Male Medical sciences Middle Aged oxidative DNA damage Pneumology Polymorphism, Genetic Retrospective Studies survival Survival Rate Tumors Tumors of the respiratory system and mediastinum
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