Simultaneous determination of benserazide and levodopa by capillary electrophoresis–chemiluminescence using an improved interface
A capillary electrophoresis coupling with indirect chemiluminescence detection method for the simultaneous determination of benserazide and levodopa has been developed. The detection interface was improved to simplify the capillary electrophoresis–chemiluminescence (CE–CL) system and the features of...
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| Veröffentlicht in: | Journal of Chromatography A 2006-10, Vol.1131 (1), p.289-292 |
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| creator | He, Wei-Wei Zhou, Xing-Wang Lu, Jian-Quan |
| description | A capillary electrophoresis coupling with indirect chemiluminescence detection method for the simultaneous determination of benserazide and levodopa has been developed. The detection interface was improved to simplify the capillary electrophoresis–chemiluminescence (CE–CL) system and the features of this improved interface were illustrated in this paper. The CE–CL conditions for the simultaneous determination of benserazide and levodopa were optimized. Under the optimal conditions, the CL intensity was linear with concentrations of levodopa in the range of 1.0 to 100.0
μg
ml
−1, and benserazide in the range of 10.0 to 1000
μg
ml
−1, respectively. The detection limits (S/N
=
3) in turn were 1.85
μg
ml
−1 for BS and 0.12
μg
ml
−1 for L-dopa with relative standard deviations of less than 3%. The proposed method has been successfully applied to the determination of benserazide and levodopa in medopar tablets and spiked urine samples, demonstrating the feasibility and reliability of the proposed method. |
| doi_str_mv | 10.1016/j.chroma.2006.08.071 |
| format | Article |
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μg
ml
−1, and benserazide in the range of 10.0 to 1000
μg
ml
−1, respectively. The detection limits (S/N
=
3) in turn were 1.85
μg
ml
−1 for BS and 0.12
μg
ml
−1 for L-dopa with relative standard deviations of less than 3%. The proposed method has been successfully applied to the determination of benserazide and levodopa in medopar tablets and spiked urine samples, demonstrating the feasibility and reliability of the proposed method.</description><identifier>ISSN: 0021-9673</identifier><identifier>DOI: 10.1016/j.chroma.2006.08.071</identifier><identifier>PMID: 16979177</identifier><identifier>CODEN: JOCRAM</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Benserazide ; Benserazide - analysis ; Biological and medical sciences ; Capillary electrophoresis ; Chemiluminescence ; Electrophoresis, Capillary - instrumentation ; Electrophoresis, Capillary - methods ; General pharmacology ; Indirect detection ; Interface ; Levodopa ; Levodopa - analysis ; Luminescent Measurements - instrumentation ; Luminescent Measurements - methods ; Medical sciences ; Pharmacology. Drug treatments ; Reproducibility of Results</subject><ispartof>Journal of Chromatography A, 2006-10, Vol.1131 (1), p.289-292</ispartof><rights>2006 Elsevier B.V.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-fb694a520e223ba8eec74c1b36aac668aa6ab0fcfc83104c90c82921597359fe3</citedby><cites>FETCH-LOGICAL-c390t-fb694a520e223ba8eec74c1b36aac668aa6ab0fcfc83104c90c82921597359fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0021967306016414$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18171692$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16979177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Wei-Wei</creatorcontrib><creatorcontrib>Zhou, Xing-Wang</creatorcontrib><creatorcontrib>Lu, Jian-Quan</creatorcontrib><title>Simultaneous determination of benserazide and levodopa by capillary electrophoresis–chemiluminescence using an improved interface</title><title>Journal of Chromatography A</title><addtitle>J Chromatogr A</addtitle><description>A capillary electrophoresis coupling with indirect chemiluminescence detection method for the simultaneous determination of benserazide and levodopa has been developed. The detection interface was improved to simplify the capillary electrophoresis–chemiluminescence (CE–CL) system and the features of this improved interface were illustrated in this paper. The CE–CL conditions for the simultaneous determination of benserazide and levodopa were optimized. Under the optimal conditions, the CL intensity was linear with concentrations of levodopa in the range of 1.0 to 100.0
μg
ml
−1, and benserazide in the range of 10.0 to 1000
μg
ml
−1, respectively. The detection limits (S/N
=
3) in turn were 1.85
μg
ml
−1 for BS and 0.12
μg
ml
−1 for L-dopa with relative standard deviations of less than 3%. The proposed method has been successfully applied to the determination of benserazide and levodopa in medopar tablets and spiked urine samples, demonstrating the feasibility and reliability of the proposed method.</description><subject>Analysis</subject><subject>Benserazide</subject><subject>Benserazide - analysis</subject><subject>Biological and medical sciences</subject><subject>Capillary electrophoresis</subject><subject>Chemiluminescence</subject><subject>Electrophoresis, Capillary - instrumentation</subject><subject>Electrophoresis, Capillary - methods</subject><subject>General pharmacology</subject><subject>Indirect detection</subject><subject>Interface</subject><subject>Levodopa</subject><subject>Levodopa - analysis</subject><subject>Luminescent Measurements - instrumentation</subject><subject>Luminescent Measurements - methods</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Reproducibility of Results</subject><issn>0021-9673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1u1DAUhbMA0dLyBgh5A7sJtjPjnw0SqoAiVWJBu7Zubq4Zj5I42MlIZYXEI_QNeZJ6mJG6Y-XNd4_P-arqteC14EK939W4TXGAWnKuam5qrsWz6pxzKVZW6easepnzjnOhuZYvqjOhrLZC6_Pqz_cwLP0MI8Uls45mSkMYYQ5xZNGzlsZMCX6FjhiMHetpH7s4AWvvGcIU-h7SPaOecE5x2sZEOeS_vx9wS0PolxJFGWlEYksO44-SwcIwpbinjoWxfOYB6bJ67qHP9Or0XlR3nz_dXl2vbr59-Xr18WaFjeXzyrfKrmEjOUnZtGCIUK9RtI0CQKUMgIKWe_RoGsHXaDkaaaXYWN1srKfmonp3zC0Ffi6UZzeE0q5s-LfeKWMba7Qq4PoIYoo5J_JuSmEoS53g7iDc7dxRuDsId9y4IrycvTnlL-1A3dPRyXYB3p4AyAi9TzBiyE-cEbqwsnAfjhwVG_tAyWUMB4tdSMW062L4f5NHzGSoRw</recordid><startdate>20061027</startdate><enddate>20061027</enddate><creator>He, Wei-Wei</creator><creator>Zhou, Xing-Wang</creator><creator>Lu, Jian-Quan</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061027</creationdate><title>Simultaneous determination of benserazide and levodopa by capillary electrophoresis–chemiluminescence using an improved interface</title><author>He, Wei-Wei ; Zhou, Xing-Wang ; Lu, Jian-Quan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-fb694a520e223ba8eec74c1b36aac668aa6ab0fcfc83104c90c82921597359fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Analysis</topic><topic>Benserazide</topic><topic>Benserazide - analysis</topic><topic>Biological and medical sciences</topic><topic>Capillary electrophoresis</topic><topic>Chemiluminescence</topic><topic>Electrophoresis, Capillary - instrumentation</topic><topic>Electrophoresis, Capillary - methods</topic><topic>General pharmacology</topic><topic>Indirect detection</topic><topic>Interface</topic><topic>Levodopa</topic><topic>Levodopa - analysis</topic><topic>Luminescent Measurements - instrumentation</topic><topic>Luminescent Measurements - methods</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Reproducibility of Results</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Wei-Wei</creatorcontrib><creatorcontrib>Zhou, Xing-Wang</creatorcontrib><creatorcontrib>Lu, Jian-Quan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Chromatography A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Wei-Wei</au><au>Zhou, Xing-Wang</au><au>Lu, Jian-Quan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simultaneous determination of benserazide and levodopa by capillary electrophoresis–chemiluminescence using an improved interface</atitle><jtitle>Journal of Chromatography A</jtitle><addtitle>J Chromatogr A</addtitle><date>2006-10-27</date><risdate>2006</risdate><volume>1131</volume><issue>1</issue><spage>289</spage><epage>292</epage><pages>289-292</pages><issn>0021-9673</issn><coden>JOCRAM</coden><abstract>A capillary electrophoresis coupling with indirect chemiluminescence detection method for the simultaneous determination of benserazide and levodopa has been developed. The detection interface was improved to simplify the capillary electrophoresis–chemiluminescence (CE–CL) system and the features of this improved interface were illustrated in this paper. The CE–CL conditions for the simultaneous determination of benserazide and levodopa were optimized. Under the optimal conditions, the CL intensity was linear with concentrations of levodopa in the range of 1.0 to 100.0
μg
ml
−1, and benserazide in the range of 10.0 to 1000
μg
ml
−1, respectively. The detection limits (S/N
=
3) in turn were 1.85
μg
ml
−1 for BS and 0.12
μg
ml
−1 for L-dopa with relative standard deviations of less than 3%. The proposed method has been successfully applied to the determination of benserazide and levodopa in medopar tablets and spiked urine samples, demonstrating the feasibility and reliability of the proposed method.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>16979177</pmid><doi>10.1016/j.chroma.2006.08.071</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Analysis Benserazide Benserazide - analysis Biological and medical sciences Capillary electrophoresis Chemiluminescence Electrophoresis, Capillary - instrumentation Electrophoresis, Capillary - methods General pharmacology Indirect detection Interface Levodopa Levodopa - analysis Luminescent Measurements - instrumentation Luminescent Measurements - methods Medical sciences Pharmacology. Drug treatments Reproducibility of Results |
| title | Simultaneous determination of benserazide and levodopa by capillary electrophoresis–chemiluminescence using an improved interface |
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