Antiosteoporotic activity of Er-Xian Decoction, a traditional Chinese herbal formula, in ovariectomized rats
The antiosteoporotic effect of a herbal formula, Er-Xian Decoction (EXD), in ovariectomized (OVX) rats model of osteoporosis was investigated. The rats were divided into Sham and OVX groups. The OVX rats were further sub-divided into four groups administered orally with water, nylestriol (1 mg/kg, w...
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| Veröffentlicht in: | Journal of ethnopharmacology 2006-11, Vol.108 (1), p.96-102 |
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| description | The antiosteoporotic effect of a herbal formula, Er-Xian Decoction (EXD), in ovariectomized (OVX) rats model of osteoporosis was investigated. The rats were divided into Sham and OVX groups. The OVX rats were further sub-divided into four groups administered orally with water, nylestriol (1
mg/kg, weekly) or EXD (300, 600
mg/kg, daily) for 12 weeks. In OVX rats, the increases of body weight, serum BGP and ALP were significantly decreased by EXD treatment. In OVX rats, atrophy of uterus and descent of BMD were suppressed by treatment with EXD and nylestriol. In addition, EXD completely corrected the decreased concentration of calcium, phosphorus, and estradiol in serum observed in OVX rats. EXD also significantly increased biomechanical strength comparable to the Sham group. This was also confirmed by histological results that showed its protective action. The findings assessed on the basis of biochemical, bone mineral density, biomechanical, and histopathological parameters strongly suggested that EXD had a definite antiosteoporotic effect, which is similar to estrogen. |
| doi_str_mv | 10.1016/j.jep.2006.04.020 |
| format | Article |
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mg/kg, weekly) or EXD (300, 600
mg/kg, daily) for 12 weeks. In OVX rats, the increases of body weight, serum BGP and ALP were significantly decreased by EXD treatment. In OVX rats, atrophy of uterus and descent of BMD were suppressed by treatment with EXD and nylestriol. In addition, EXD completely corrected the decreased concentration of calcium, phosphorus, and estradiol in serum observed in OVX rats. EXD also significantly increased biomechanical strength comparable to the Sham group. This was also confirmed by histological results that showed its protective action. The findings assessed on the basis of biochemical, bone mineral density, biomechanical, and histopathological parameters strongly suggested that EXD had a definite antiosteoporotic effect, which is similar to estrogen.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2006.04.020</identifier><identifier>PMID: 16765003</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Anemarrhena asphodeloides ; Angelica sinensis ; Animals ; Antiosteoporotic ; bark ; Berberidaceae ; bioassays ; Biological and medical sciences ; Body Weight - drug effects ; bone density ; Bone Density Conservation Agents - pharmacology ; Bone Density Conservation Agents - therapeutic use ; Bone mineral density ; chemical constituents of plants ; Curculigo orchioides ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal - pharmacology ; Drugs, Chinese Herbal - therapeutic use ; Epimedium sagittatum ; Er-Xian Decoction (EXD) ; ethnobotany ; Female ; General pharmacology ; herbal medicines ; Histomorphometry ; Liliaceae ; Mechanical strength ; Medical sciences ; medicinal plants ; medicinal properties ; Medicine, Chinese Traditional ; Morinda officinalis ; Organ Size - drug effects ; Oriental traditional medicine ; osteoporosis ; Osteoporosis - prevention & control ; Ovariectomy ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phellodendron ; Phellodendron chinense ; plant extracts ; Plants, Medicinal ; Quinestrol - analogs & derivatives ; Quinestrol - therapeutic use ; Rats ; Rats, Sprague-Dawley ; rhizomes ; roots ; Rubiaceae ; Uterus - anatomy & histology ; Uterus - drug effects</subject><ispartof>Journal of ethnopharmacology, 2006-11, Vol.108 (1), p.96-102</ispartof><rights>2006 Elsevier Ireland Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-3e8fcff4187fa8b29d9bb8fd5a4abc1856a514545b1e4825615100f35ec33efd3</citedby><cites>FETCH-LOGICAL-c405t-3e8fcff4187fa8b29d9bb8fd5a4abc1856a514545b1e4825615100f35ec33efd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2006.04.020$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18395079$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16765003$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nian, Hua</creatorcontrib><creatorcontrib>Qin, Lu-Ping</creatorcontrib><creatorcontrib>Zhang, Qiao-Yan</creatorcontrib><creatorcontrib>Zheng, Han-Chen</creatorcontrib><creatorcontrib>Yu, Yuan</creatorcontrib><creatorcontrib>Huang, Bao-Kang</creatorcontrib><title>Antiosteoporotic activity of Er-Xian Decoction, a traditional Chinese herbal formula, in ovariectomized rats</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>The antiosteoporotic effect of a herbal formula, Er-Xian Decoction (EXD), in ovariectomized (OVX) rats model of osteoporosis was investigated. The rats were divided into Sham and OVX groups. The OVX rats were further sub-divided into four groups administered orally with water, nylestriol (1
mg/kg, weekly) or EXD (300, 600
mg/kg, daily) for 12 weeks. In OVX rats, the increases of body weight, serum BGP and ALP were significantly decreased by EXD treatment. In OVX rats, atrophy of uterus and descent of BMD were suppressed by treatment with EXD and nylestriol. In addition, EXD completely corrected the decreased concentration of calcium, phosphorus, and estradiol in serum observed in OVX rats. EXD also significantly increased biomechanical strength comparable to the Sham group. This was also confirmed by histological results that showed its protective action. The findings assessed on the basis of biochemical, bone mineral density, biomechanical, and histopathological parameters strongly suggested that EXD had a definite antiosteoporotic effect, which is similar to estrogen.</description><subject>Anemarrhena asphodeloides</subject><subject>Angelica sinensis</subject><subject>Animals</subject><subject>Antiosteoporotic</subject><subject>bark</subject><subject>Berberidaceae</subject><subject>bioassays</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>bone density</subject><subject>Bone Density Conservation Agents - pharmacology</subject><subject>Bone Density Conservation Agents - therapeutic use</subject><subject>Bone mineral density</subject><subject>chemical constituents of plants</subject><subject>Curculigo orchioides</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Drugs, Chinese Herbal - therapeutic use</subject><subject>Epimedium sagittatum</subject><subject>Er-Xian Decoction (EXD)</subject><subject>ethnobotany</subject><subject>Female</subject><subject>General pharmacology</subject><subject>herbal medicines</subject><subject>Histomorphometry</subject><subject>Liliaceae</subject><subject>Mechanical strength</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>Medicine, Chinese Traditional</subject><subject>Morinda officinalis</subject><subject>Organ Size - drug effects</subject><subject>Oriental traditional medicine</subject><subject>osteoporosis</subject><subject>Osteoporosis - prevention & control</subject><subject>Ovariectomy</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phellodendron</subject><subject>Phellodendron chinense</subject><subject>plant extracts</subject><subject>Plants, Medicinal</subject><subject>Quinestrol - analogs & derivatives</subject><subject>Quinestrol - therapeutic use</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>rhizomes</subject><subject>roots</subject><subject>Rubiaceae</subject><subject>Uterus - anatomy & histology</subject><subject>Uterus - drug effects</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2P1DAMQCsEYoeFH8AFcoHTtjhN0qbitBqWD2klDrASt8hNHTajTjMkmZGWX09GM9LeOFm2ni37uapec2g48O7DptnQrmkBugZkAy08qVZc923dq148rVYgel3rXvKL6kVKGwDouYTn1QXv-k4BiFU1Xy_Zh5Qp7EIM2VuGNvuDzw8sOHYT618eF_aJbCjlsFwxZDni5I8Jzmx97xdKxO4pjiV1IW73M14xv7BwwOjJ5rD1f2liEXN6WT1zOCd6dY6X1d3nm5_rr_Xt9y_f1te3tZWgci1IO-ucLKc41GM7TMM4ajcplDharlWHiksl1chJ6lZ1XHEAJxRZIchN4rJ6f5q7i-HPnlI2W58szTMuFPbJdHoQQ9fyAvITaGNIKZIzu-i3GB8MB3NUbDamKDZHxQakKYpLz5vz8P24pemx4-y0AO_OACaLs4u4WJ8eOS0GBf1QuLcnzmEw-DsW5u5HC1yUN4lOtkfi44mgIuvgKZpkPS2WJh-LWTMF_59F_wGc3aOz</recordid><startdate>20061103</startdate><enddate>20061103</enddate><creator>Nian, Hua</creator><creator>Qin, Lu-Ping</creator><creator>Zhang, Qiao-Yan</creator><creator>Zheng, Han-Chen</creator><creator>Yu, Yuan</creator><creator>Huang, Bao-Kang</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061103</creationdate><title>Antiosteoporotic activity of Er-Xian Decoction, a traditional Chinese herbal formula, in ovariectomized rats</title><author>Nian, Hua ; Qin, Lu-Ping ; Zhang, Qiao-Yan ; Zheng, Han-Chen ; Yu, Yuan ; Huang, Bao-Kang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-3e8fcff4187fa8b29d9bb8fd5a4abc1856a514545b1e4825615100f35ec33efd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Anemarrhena asphodeloides</topic><topic>Angelica sinensis</topic><topic>Animals</topic><topic>Antiosteoporotic</topic><topic>bark</topic><topic>Berberidaceae</topic><topic>bioassays</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>bone density</topic><topic>Bone Density Conservation Agents - pharmacology</topic><topic>Bone Density Conservation Agents - therapeutic use</topic><topic>Bone mineral density</topic><topic>chemical constituents of plants</topic><topic>Curculigo orchioides</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Drugs, Chinese Herbal - therapeutic use</topic><topic>Epimedium sagittatum</topic><topic>Er-Xian Decoction (EXD)</topic><topic>ethnobotany</topic><topic>Female</topic><topic>General pharmacology</topic><topic>herbal medicines</topic><topic>Histomorphometry</topic><topic>Liliaceae</topic><topic>Mechanical strength</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>Medicine, Chinese Traditional</topic><topic>Morinda officinalis</topic><topic>Organ Size - drug effects</topic><topic>Oriental traditional medicine</topic><topic>osteoporosis</topic><topic>Osteoporosis - prevention & control</topic><topic>Ovariectomy</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phellodendron</topic><topic>Phellodendron chinense</topic><topic>plant extracts</topic><topic>Plants, Medicinal</topic><topic>Quinestrol - analogs & derivatives</topic><topic>Quinestrol - therapeutic use</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>rhizomes</topic><topic>roots</topic><topic>Rubiaceae</topic><topic>Uterus - anatomy & histology</topic><topic>Uterus - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nian, Hua</creatorcontrib><creatorcontrib>Qin, Lu-Ping</creatorcontrib><creatorcontrib>Zhang, Qiao-Yan</creatorcontrib><creatorcontrib>Zheng, Han-Chen</creatorcontrib><creatorcontrib>Yu, Yuan</creatorcontrib><creatorcontrib>Huang, Bao-Kang</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nian, Hua</au><au>Qin, Lu-Ping</au><au>Zhang, Qiao-Yan</au><au>Zheng, Han-Chen</au><au>Yu, Yuan</au><au>Huang, Bao-Kang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiosteoporotic activity of Er-Xian Decoction, a traditional Chinese herbal formula, in ovariectomized rats</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2006-11-03</date><risdate>2006</risdate><volume>108</volume><issue>1</issue><spage>96</spage><epage>102</epage><pages>96-102</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>The antiosteoporotic effect of a herbal formula, Er-Xian Decoction (EXD), in ovariectomized (OVX) rats model of osteoporosis was investigated. The rats were divided into Sham and OVX groups. The OVX rats were further sub-divided into four groups administered orally with water, nylestriol (1
mg/kg, weekly) or EXD (300, 600
mg/kg, daily) for 12 weeks. In OVX rats, the increases of body weight, serum BGP and ALP were significantly decreased by EXD treatment. In OVX rats, atrophy of uterus and descent of BMD were suppressed by treatment with EXD and nylestriol. In addition, EXD completely corrected the decreased concentration of calcium, phosphorus, and estradiol in serum observed in OVX rats. EXD also significantly increased biomechanical strength comparable to the Sham group. This was also confirmed by histological results that showed its protective action. The findings assessed on the basis of biochemical, bone mineral density, biomechanical, and histopathological parameters strongly suggested that EXD had a definite antiosteoporotic effect, which is similar to estrogen.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>16765003</pmid><doi>10.1016/j.jep.2006.04.020</doi><tpages>7</tpages></addata></record> |
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| subjects | Anemarrhena asphodeloides Angelica sinensis Animals Antiosteoporotic bark Berberidaceae bioassays Biological and medical sciences Body Weight - drug effects bone density Bone Density Conservation Agents - pharmacology Bone Density Conservation Agents - therapeutic use Bone mineral density chemical constituents of plants Curculigo orchioides Dose-Response Relationship, Drug Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Epimedium sagittatum Er-Xian Decoction (EXD) ethnobotany Female General pharmacology herbal medicines Histomorphometry Liliaceae Mechanical strength Medical sciences medicinal plants medicinal properties Medicine, Chinese Traditional Morinda officinalis Organ Size - drug effects Oriental traditional medicine osteoporosis Osteoporosis - prevention & control Ovariectomy Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phellodendron Phellodendron chinense plant extracts Plants, Medicinal Quinestrol - analogs & derivatives Quinestrol - therapeutic use Rats Rats, Sprague-Dawley rhizomes roots Rubiaceae Uterus - anatomy & histology Uterus - drug effects |
| title | Antiosteoporotic activity of Er-Xian Decoction, a traditional Chinese herbal formula, in ovariectomized rats |
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