Variants in the 5alpha-reductase type 1 and type 2 genes are associated with polycystic ovary syndrome and the severity of hirsutism in affected women

Despite the importance of dihydrotestosterone in androgen action, polymorphisms in the genes for the two isoforms of 5alpha-reductase (SRD5A1 and SRD5A2) have not been evaluated as risk factors for polycystic ovary syndrome (PCOS). The objective of the study was to test the hypothesis that haplotype...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2006-10, Vol.91 (10), p.4085-4091
Hauptverfasser:	Goodarzi, Mark O, Shah, Nissar A, Antoine, Heath J, Pall, Marita, Guo, Xiuqing, Azziz, Ricardo
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics Adolescent Adult Female Haplotypes Hirsutism - genetics Humans Isoenzymes - genetics Middle Aged Polycystic Ovary Syndrome - genetics Polymorphism, Single Nucleotide Risk Factors
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