Caveolar Endocytosis and Microdomain Association of a Glycosphingolipid Analog Is Dependent on Its Sphingosine Stereochemistry

We have previously shown that glycosphingolipid analogs are internalized primarily via caveolae in various cell types. This selective internalization was not dependent on particular carbohydrate headgroups or sphingosine chain length. Here, we examine the role of sphingosine structure in the endocyt...

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Veröffentlicht in:	The Journal of biological chemistry 2006-10, Vol.281 (41), p.30660-30668
Hauptverfasser:	Singh, Raman Deep, Liu, Yidong, Wheatley, Christine L., Holicky, Eileen L., Makino, Asami, Marks, David L., Kobayashi, Toshihide, Subramaniam, Gopal, Bittman, Robert, Pagano, Richard E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Boron Compounds - chemistry Caveolae - metabolism Cells, Cultured Disaccharides - chemistry Endocytosis Glycosphingolipids - chemistry Humans Lipids - chemistry Models, Chemical Models, Molecular Protein Structure, Tertiary Spectrometry, Fluorescence Sphingosine - chemistry Stereoisomerism
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