Disulfide-dependent Protein Folding Is Linked to Operation of the Vitamin K Cycle in the Endoplasmic Reticulum: A PROTEIN DISULFIDE ISOMERASE-VKORC1 REDOX ENZYME COMPLEX APPEARS TO BE RESPONSIBLE FOR VITAMIN K₁ 2,3-EPOXIDE REDUCTION

γ-Carboxylation of vitamin K-dependent proteins is dependent on formation of reduced vitamin K₁ (Vit.K₁H₂) in the endoplasmic reticulum (ER), where it works as an essential cofactor for γ-carboxylase in post-translational γ-carboxylation of vitamin K-dependent proteins. Vit.K₁H₂ is produced by the w...

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Veröffentlicht in:	The Journal of biological chemistry 2007-01, Vol.282 (4), p.2626-2635
Hauptverfasser:	Wajih, Nadeem, Hutson, Susan M, Wallin, Reidar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport Carbon-Carbon Ligases - metabolism Cell Line Cricetinae Endoplasmic Reticulum - metabolism Mixed Function Oxygenases - metabolism Oxidation-Reduction Protein Disulfide-Isomerases - metabolism Protein Folding Toluene - analogs & derivatives Vitamin K - metabolism Vitamin K 1 - analogs & derivatives Vitamin K 1 - metabolism Vitamin K Epoxide Reductases
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