A Phase 1–2 Dose-Escalating Study Evaluating the Safety and Tolerability of Istaroxime and Specific Effects on Electrocardiographic and Hemodynamic Parameters in Patients with Chronic Heart Failure with Reduced Systolic Function

Istaroxime (PST2744) is a luso-inotrope that stimulates the sarcoplasmic reticulum calcium adenosine triphosphatase isoform 2a without chronotropic effects. Additionally, it has beneficial effects on myocardial energetics. This phase 1–2 clinical trial in patients with chronic stable heart failure (...

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Veröffentlicht in:	The American journal of cardiology 2007-01, Vol.99 (2), p.S47-S56
Hauptverfasser:	Ghali, Jalal K., MD, Smith, William B., MD, Torre-Amione, Guillermo, MD, Haynos, William, MD, Rayburn, Barry K., MD, Amato, Antonino, MD, Zhang, Dan, MD, Cowart, Doug, PharmD, Valentini, Giovanni, MD, Carminati, Paolo, MD, Gheorghiade, Mihai, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Blood pressure Blood Pressure - drug effects Cardiography, Impedance - drug effects Cardiology Cardiotonic Agents - pharmacokinetics Cardiotonic Agents - pharmacology Cardiotonic Agents - therapeutic use Cardiovascular Cardiovascular system Dose-Response Relationship, Drug Drug therapy Etiocholanolone - analogs & derivatives Etiocholanolone - pharmacokinetics Etiocholanolone - pharmacology Etiocholanolone - therapeutic use Female Half-Life Heart attacks Heart failure Heart Failure - drug therapy Heart Rate - drug effects Humans Infusions, Intravenous Male Middle Aged Myocardial Contraction - drug effects
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