Principal Components Analysis of Obsessive–Compulsive Disorder Symptoms in Children and Adolescents
Background Obsessive–compulsive disorder (OCD) has a broadly diverse clinical expression that may reflect etiologic heterogeneity. Several adult studies have identified consistent symptom dimensions of OCD. The purpose of this study was to conduct an exploratory principal components analysis of obse...
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description | Background Obsessive–compulsive disorder (OCD) has a broadly diverse clinical expression that may reflect etiologic heterogeneity. Several adult studies have identified consistent symptom dimensions of OCD. The purpose of this study was to conduct an exploratory principal components analysis of obsessive–compulsive (OC) symptoms in children and adolescents with OCD to identify improved phenotypes for future studies. Methods This study examined lifetime occurrence of OC symptoms included in the 13 symptom categories of the Yale–Brown Obsessive Compulsive Scale (Y-BOCS) and the Children’s Yale-Brown Obsessive–Compulsive Scale (CY-BOCS). Principal components analysis with promax rotation was performed on 231 children and adolescents with OCD and compared with results of similar adult studies. Results A four-factor solution emerged explaining 59.8% of symptom variance characterized by 1) symmetry/ordering/repeating/checking; 2) contamination/cleaning/aggressive/somatic; 3) hoarding; and 4) sexual/religious symptoms. All factors included core symptoms that have been consistently observed in adult studies of OCD. Conclusions In children and adolescents, OCD is a multidimensional disorder. Symptom dimensions are predominantly congruent with those described in similar studies of adults with OCD, suggesting fairly consistent covariation of OCD symptoms through the developmental course. Future work is required to understand changes in specific symptom dimensions observed across the life span. |
doi_str_mv | 10.1016/j.biopsych.2006.08.040 |
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Evelyn ; Rosario, Maria C ; Brown, Timothy A ; Carter, Alice S ; Leckman, James F ; Sukhodolsky, Denis ; Katsovitch, Liliya ; King, Robert ; Geller, Daniel ; Pauls, David L</creator><creatorcontrib>Stewart, S. Evelyn ; Rosario, Maria C ; Brown, Timothy A ; Carter, Alice S ; Leckman, James F ; Sukhodolsky, Denis ; Katsovitch, Liliya ; King, Robert ; Geller, Daniel ; Pauls, David L</creatorcontrib><description>Background Obsessive–compulsive disorder (OCD) has a broadly diverse clinical expression that may reflect etiologic heterogeneity. Several adult studies have identified consistent symptom dimensions of OCD. The purpose of this study was to conduct an exploratory principal components analysis of obsessive–compulsive (OC) symptoms in children and adolescents with OCD to identify improved phenotypes for future studies. Methods This study examined lifetime occurrence of OC symptoms included in the 13 symptom categories of the Yale–Brown Obsessive Compulsive Scale (Y-BOCS) and the Children’s Yale-Brown Obsessive–Compulsive Scale (CY-BOCS). Principal components analysis with promax rotation was performed on 231 children and adolescents with OCD and compared with results of similar adult studies. Results A four-factor solution emerged explaining 59.8% of symptom variance characterized by 1) symmetry/ordering/repeating/checking; 2) contamination/cleaning/aggressive/somatic; 3) hoarding; and 4) sexual/religious symptoms. All factors included core symptoms that have been consistently observed in adult studies of OCD. Conclusions In children and adolescents, OCD is a multidimensional disorder. Symptom dimensions are predominantly congruent with those described in similar studies of adults with OCD, suggesting fairly consistent covariation of OCD symptoms through the developmental course. Future work is required to understand changes in specific symptom dimensions observed across the life span.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/j.biopsych.2006.08.040</identifier><identifier>PMID: 17161383</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adolescents ; Age Factors ; Aggression - psychology ; Child ; children ; dimension ; factor ; Female ; Humans ; Male ; Obsessive-Compulsive Disorder - epidemiology ; obsessive–compulsive disorder ; phenomenology ; Phenotype ; Principal Component Analysis ; Psychiatric Status Rating Scales ; Psychiatry ; Sex Factors ; Sexual Behavior</subject><ispartof>Biological psychiatry (1969), 2007-02, Vol.61 (3), p.285-291</ispartof><rights>Society of Biological Psychiatry</rights><rights>2007 Society of Biological Psychiatry</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-a795abca1d655d579b5b13715a72315e92328e356d5e497984998070f37ca41d3</citedby><cites>FETCH-LOGICAL-c518t-a795abca1d655d579b5b13715a72315e92328e356d5e497984998070f37ca41d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biopsych.2006.08.040$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17161383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stewart, S. Evelyn</creatorcontrib><creatorcontrib>Rosario, Maria C</creatorcontrib><creatorcontrib>Brown, Timothy A</creatorcontrib><creatorcontrib>Carter, Alice S</creatorcontrib><creatorcontrib>Leckman, James F</creatorcontrib><creatorcontrib>Sukhodolsky, Denis</creatorcontrib><creatorcontrib>Katsovitch, Liliya</creatorcontrib><creatorcontrib>King, Robert</creatorcontrib><creatorcontrib>Geller, Daniel</creatorcontrib><creatorcontrib>Pauls, David L</creatorcontrib><title>Principal Components Analysis of Obsessive–Compulsive Disorder Symptoms in Children and Adolescents</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Background Obsessive–compulsive disorder (OCD) has a broadly diverse clinical expression that may reflect etiologic heterogeneity. Several adult studies have identified consistent symptom dimensions of OCD. The purpose of this study was to conduct an exploratory principal components analysis of obsessive–compulsive (OC) symptoms in children and adolescents with OCD to identify improved phenotypes for future studies. Methods This study examined lifetime occurrence of OC symptoms included in the 13 symptom categories of the Yale–Brown Obsessive Compulsive Scale (Y-BOCS) and the Children’s Yale-Brown Obsessive–Compulsive Scale (CY-BOCS). Principal components analysis with promax rotation was performed on 231 children and adolescents with OCD and compared with results of similar adult studies. Results A four-factor solution emerged explaining 59.8% of symptom variance characterized by 1) symmetry/ordering/repeating/checking; 2) contamination/cleaning/aggressive/somatic; 3) hoarding; and 4) sexual/religious symptoms. All factors included core symptoms that have been consistently observed in adult studies of OCD. Conclusions In children and adolescents, OCD is a multidimensional disorder. Symptom dimensions are predominantly congruent with those described in similar studies of adults with OCD, suggesting fairly consistent covariation of OCD symptoms through the developmental course. Future work is required to understand changes in specific symptom dimensions observed across the life span.</description><subject>Adolescent</subject><subject>Adolescents</subject><subject>Age Factors</subject><subject>Aggression - psychology</subject><subject>Child</subject><subject>children</subject><subject>dimension</subject><subject>factor</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Obsessive-Compulsive Disorder - epidemiology</subject><subject>obsessive–compulsive disorder</subject><subject>phenomenology</subject><subject>Phenotype</subject><subject>Principal Component Analysis</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Sex Factors</subject><subject>Sexual Behavior</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkuO1DAQhiMEYpqBK4y8YtfBj_iRDaLVw0saaZAG1pZjV2vcJHawk5Gy4w7ckJPgqBshsRlvrJK_-qtcf1XVFcE1wUS8Odadj2Ne7H1NMRY1VjVu8JNqQ5RkW9pg-rTa4PKyZZSyi-pFzscSSkrJ8-qCSCIIU2xTwZfkg_Wj6dE-DmMMEKaMdsH0S_YZxQO67TLk7B_g989fKzL3a4CufY7JQUJ3yzBOccjIB7S_971LEJAJDu1c7CHbVfBl9exg-gyvzvdl9e3D-6_7T9ub24-f97ubreVETVsjW246a4gTnDsu2453hEnCjaSMcGgpowoYF45D08pWNW2rsMQHJq1piGOX1euT7pjijxnypAdfOuh7EyDOWQvVMqZI8yhIWtEKTFUBxQm0Keac4KDH5AeTFk2wXp3QR_3XCb06obHSxYmSeHWuMHcDuH9p59EX4N0JgDKQBw9JZ-shWHA-gZ20i_7xGm__k7C9D96a_jsskI9xTsXI8hudqcb6bt2HdR2wwKQczv4Ad4iznA</recordid><startdate>20070201</startdate><enddate>20070201</enddate><creator>Stewart, S. Evelyn</creator><creator>Rosario, Maria C</creator><creator>Brown, Timothy A</creator><creator>Carter, Alice S</creator><creator>Leckman, James F</creator><creator>Sukhodolsky, Denis</creator><creator>Katsovitch, Liliya</creator><creator>King, Robert</creator><creator>Geller, Daniel</creator><creator>Pauls, David L</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20070201</creationdate><title>Principal Components Analysis of Obsessive–Compulsive Disorder Symptoms in Children and Adolescents</title><author>Stewart, S. Evelyn ; Rosario, Maria C ; Brown, Timothy A ; Carter, Alice S ; Leckman, James F ; Sukhodolsky, Denis ; Katsovitch, Liliya ; King, Robert ; Geller, Daniel ; Pauls, David L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c518t-a795abca1d655d579b5b13715a72315e92328e356d5e497984998070f37ca41d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adolescents</topic><topic>Age Factors</topic><topic>Aggression - psychology</topic><topic>Child</topic><topic>children</topic><topic>dimension</topic><topic>factor</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Obsessive-Compulsive Disorder - epidemiology</topic><topic>obsessive–compulsive disorder</topic><topic>phenomenology</topic><topic>Phenotype</topic><topic>Principal Component Analysis</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Sex Factors</topic><topic>Sexual Behavior</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stewart, S. Evelyn</creatorcontrib><creatorcontrib>Rosario, Maria C</creatorcontrib><creatorcontrib>Brown, Timothy A</creatorcontrib><creatorcontrib>Carter, Alice S</creatorcontrib><creatorcontrib>Leckman, James F</creatorcontrib><creatorcontrib>Sukhodolsky, Denis</creatorcontrib><creatorcontrib>Katsovitch, Liliya</creatorcontrib><creatorcontrib>King, Robert</creatorcontrib><creatorcontrib>Geller, Daniel</creatorcontrib><creatorcontrib>Pauls, David L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stewart, S. Evelyn</au><au>Rosario, Maria C</au><au>Brown, Timothy A</au><au>Carter, Alice S</au><au>Leckman, James F</au><au>Sukhodolsky, Denis</au><au>Katsovitch, Liliya</au><au>King, Robert</au><au>Geller, Daniel</au><au>Pauls, David L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Principal Components Analysis of Obsessive–Compulsive Disorder Symptoms in Children and Adolescents</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2007-02-01</date><risdate>2007</risdate><volume>61</volume><issue>3</issue><spage>285</spage><epage>291</epage><pages>285-291</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><abstract>Background Obsessive–compulsive disorder (OCD) has a broadly diverse clinical expression that may reflect etiologic heterogeneity. Several adult studies have identified consistent symptom dimensions of OCD. The purpose of this study was to conduct an exploratory principal components analysis of obsessive–compulsive (OC) symptoms in children and adolescents with OCD to identify improved phenotypes for future studies. Methods This study examined lifetime occurrence of OC symptoms included in the 13 symptom categories of the Yale–Brown Obsessive Compulsive Scale (Y-BOCS) and the Children’s Yale-Brown Obsessive–Compulsive Scale (CY-BOCS). Principal components analysis with promax rotation was performed on 231 children and adolescents with OCD and compared with results of similar adult studies. Results A four-factor solution emerged explaining 59.8% of symptom variance characterized by 1) symmetry/ordering/repeating/checking; 2) contamination/cleaning/aggressive/somatic; 3) hoarding; and 4) sexual/religious symptoms. All factors included core symptoms that have been consistently observed in adult studies of OCD. Conclusions In children and adolescents, OCD is a multidimensional disorder. Symptom dimensions are predominantly congruent with those described in similar studies of adults with OCD, suggesting fairly consistent covariation of OCD symptoms through the developmental course. Future work is required to understand changes in specific symptom dimensions observed across the life span.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>17161383</pmid><doi>10.1016/j.biopsych.2006.08.040</doi><tpages>7</tpages></addata></record> |
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subjects | Adolescent Adolescents Age Factors Aggression - psychology Child children dimension factor Female Humans Male Obsessive-Compulsive Disorder - epidemiology obsessive–compulsive disorder phenomenology Phenotype Principal Component Analysis Psychiatric Status Rating Scales Psychiatry Sex Factors Sexual Behavior |
title | Principal Components Analysis of Obsessive–Compulsive Disorder Symptoms in Children and Adolescents |
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