Coreceptor Switching in HIV-1 Subtype B and Subtype C
We use a mathematical model to determine the factors affecting the delayed or rare coreceptor switch in HIV-1 subtype C infected individuals. The model takes into account the two main target cells for the CXCR4-tropic and CCR5-tropic virus and includes the the lytic and non-lytic immune responses. C...
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| Veröffentlicht in: | Bulletin of mathematical biology 2007, Vol.69 (1), p.55-75 |
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| creator | Mugwagwa, T Witten, G |
| description | We use a mathematical model to determine the factors affecting the delayed or rare coreceptor switch in HIV-1 subtype C infected individuals. The model takes into account the two main target cells for the CXCR4-tropic and CCR5-tropic virus and includes the the lytic and non-lytic immune responses. Computer-based simulations and a sensitivity analysis of the model predict that a persistent immune response suppresses the CXCR4-tropic virus to low levels and hence preventing a phenotypic switch. However, not only should the immune response be persistent, but it should have an efficient lytic immune response rather that an efficient non-lytic response. In addition, we also find that the availability of macrophage cells and enhanced viral kinetics are also crucial for the dominance of the R5 strain. We suggest that an altered host environment probably as a result of immune activation may explain the difference in coreceptor switching kinetics between HIV-1 subtype B and subtype C individuals. |
| doi_str_mv | 10.1007/s11538-006-9137-1 |
| format | Article |
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| ispartof | Bulletin of mathematical biology, 2007, Vol.69 (1), p.55-75 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | HIV Infections - virology HIV-1 - classification HIV-1 - physiology Human immunodeficiency virus 1 Humans Models, Biological Receptors, CCR5 - metabolism Receptors, CXCR4 - metabolism |
| title | Coreceptor Switching in HIV-1 Subtype B and Subtype C |
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