Importance of complete revascularization in patients with acute myocardial infarction treated with percutaneous coronary intervention
Background The role of incomplete revascularization (ICR) in patients with acute myocardial infarction (AMI) is controversial. We evaluated the impact of ICR on short- and long-term outcome in patients with AMI and multivessel disease (MVD) treated with percutaneous coronary interventions (PCI) duri...
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Veröffentlicht in: | The American heart journal 2007-02, Vol.153 (2), p.304-312 |
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creator | Kalarus, Zbigniew, MD Lenarczyk, Radosław, MD Kowalczyk, Jacek, MD Kowalski, Oskar, MD Gąsior, Mariusz, MD Wąs, Tomasz, MD Zębik, Tadeusz, MD Krupa, Hubert, MD Chodór, Piotr, MD Poloński, Lech, MD, PhD Zembala, Marian, MD, PhD |
description | Background The role of incomplete revascularization (ICR) in patients with acute myocardial infarction (AMI) is controversial. We evaluated the impact of ICR on short- and long-term outcome in patients with AMI and multivessel disease (MVD) treated with percutaneous coronary interventions (PCI) during index hospital stay. Methods Single-center observational study covered 798 patients with MVD selected from 1486 consecutive patients with AMI treated with PCI. At discharge, 605 (75.8%) of the patients still had at least 1 diseased artery (ICR group); in 193, complete revascularization (CR) has been achieved (CR group). Any-cause mortality rate and major adverse cardiac events (MACE) during hospitalization, within a follow-up period of 30 days and 29.7 months, were compared between both groups in the whole population and within the high-risk subgroups. Propensity model to predict the probability of CR according to 16 variables was used. Results Mortality and MACE rates were significantly higher in ICR group than among completely revascularized subjects during short- and long-term observation (remote mortality 18.5% vs 7.2%, MACE 53.1% vs 24.3%, both P < .001). Higher mortality rate was also observed within the subgroups with diabetes (25.2% vs 4.8%), renal dysfunction (44.1% vs 13.8%), and lowered ejection fraction (26.5% vs 10.5%, all P < .05). Propensity-adjusted multivariate analysis showed that ICR was a significant and strong predictor of remote death (propensity-adjusted hazard ratio 2.01, 95% CI 1.71-2.31, P = .02) and MACE (hazard ratio 2.08, 95% CI 1.90-2.26, P < .001). Conclusions Incomplete revascularization is a strong and independent risk factor of death and MACE in patients with AMI treated with PCI. |
doi_str_mv | 10.1016/j.ahj.2006.10.033 |
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We evaluated the impact of ICR on short- and long-term outcome in patients with AMI and multivessel disease (MVD) treated with percutaneous coronary interventions (PCI) during index hospital stay. Methods Single-center observational study covered 798 patients with MVD selected from 1486 consecutive patients with AMI treated with PCI. At discharge, 605 (75.8%) of the patients still had at least 1 diseased artery (ICR group); in 193, complete revascularization (CR) has been achieved (CR group). Any-cause mortality rate and major adverse cardiac events (MACE) during hospitalization, within a follow-up period of 30 days and 29.7 months, were compared between both groups in the whole population and within the high-risk subgroups. Propensity model to predict the probability of CR according to 16 variables was used. Results Mortality and MACE rates were significantly higher in ICR group than among completely revascularized subjects during short- and long-term observation (remote mortality 18.5% vs 7.2%, MACE 53.1% vs 24.3%, both P < .001). Higher mortality rate was also observed within the subgroups with diabetes (25.2% vs 4.8%), renal dysfunction (44.1% vs 13.8%), and lowered ejection fraction (26.5% vs 10.5%, all P < .05). Propensity-adjusted multivariate analysis showed that ICR was a significant and strong predictor of remote death (propensity-adjusted hazard ratio 2.01, 95% CI 1.71-2.31, P = .02) and MACE (hazard ratio 2.08, 95% CI 1.90-2.26, P < .001). Conclusions Incomplete revascularization is a strong and independent risk factor of death and MACE in patients with AMI treated with PCI.</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1016/j.ahj.2006.10.033</identifier><identifier>PMID: 17239694</identifier><identifier>CODEN: AHJOA2</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Angioplasty, Balloon, Coronary ; Biological and medical sciences ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; Coronary heart disease ; Coronary vessels ; Diseases of the cardiovascular system ; Female ; Heart ; Heart attacks ; Hospitalization ; Humans ; Male ; Medical sciences ; Middle Aged ; Mortality ; Myocardial Infarction - therapy ; Prognosis ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Time Factors ; Treatment Outcome</subject><ispartof>The American heart journal, 2007-02, Vol.153 (2), p.304-312</ispartof><rights>Mosby, Inc.</rights><rights>2007 Mosby, Inc.</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Elsevier Limited Feb 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-b0000248d461cd6558b130a776cdea67c7df83139487fb688a2cc3955bc084633</citedby><cites>FETCH-LOGICAL-c464t-b0000248d461cd6558b130a776cdea67c7df83139487fb688a2cc3955bc084633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002870306009689$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19906974$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17239694$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kalarus, Zbigniew, MD</creatorcontrib><creatorcontrib>Lenarczyk, Radosław, MD</creatorcontrib><creatorcontrib>Kowalczyk, Jacek, MD</creatorcontrib><creatorcontrib>Kowalski, Oskar, MD</creatorcontrib><creatorcontrib>Gąsior, Mariusz, MD</creatorcontrib><creatorcontrib>Wąs, Tomasz, MD</creatorcontrib><creatorcontrib>Zębik, Tadeusz, MD</creatorcontrib><creatorcontrib>Krupa, Hubert, MD</creatorcontrib><creatorcontrib>Chodór, Piotr, MD</creatorcontrib><creatorcontrib>Poloński, Lech, MD, PhD</creatorcontrib><creatorcontrib>Zembala, Marian, MD, PhD</creatorcontrib><title>Importance of complete revascularization in patients with acute myocardial infarction treated with percutaneous coronary intervention</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description>Background The role of incomplete revascularization (ICR) in patients with acute myocardial infarction (AMI) is controversial. We evaluated the impact of ICR on short- and long-term outcome in patients with AMI and multivessel disease (MVD) treated with percutaneous coronary interventions (PCI) during index hospital stay. Methods Single-center observational study covered 798 patients with MVD selected from 1486 consecutive patients with AMI treated with PCI. At discharge, 605 (75.8%) of the patients still had at least 1 diseased artery (ICR group); in 193, complete revascularization (CR) has been achieved (CR group). Any-cause mortality rate and major adverse cardiac events (MACE) during hospitalization, within a follow-up period of 30 days and 29.7 months, were compared between both groups in the whole population and within the high-risk subgroups. Propensity model to predict the probability of CR according to 16 variables was used. Results Mortality and MACE rates were significantly higher in ICR group than among completely revascularized subjects during short- and long-term observation (remote mortality 18.5% vs 7.2%, MACE 53.1% vs 24.3%, both P < .001). Higher mortality rate was also observed within the subgroups with diabetes (25.2% vs 4.8%), renal dysfunction (44.1% vs 13.8%), and lowered ejection fraction (26.5% vs 10.5%, all P < .05). Propensity-adjusted multivariate analysis showed that ICR was a significant and strong predictor of remote death (propensity-adjusted hazard ratio 2.01, 95% CI 1.71-2.31, P = .02) and MACE (hazard ratio 2.08, 95% CI 1.90-2.26, P < .001). Conclusions Incomplete revascularization is a strong and independent risk factor of death and MACE in patients with AMI treated with PCI.</description><subject>Angioplasty, Balloon, Coronary</subject><subject>Biological and medical sciences</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Coronary heart disease</subject><subject>Coronary vessels</subject><subject>Diseases of the cardiovascular system</subject><subject>Female</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Myocardial Infarction - therapy</subject><subject>Prognosis</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kk2L1TAUhoMozp3RH-BGCqK7XpMmTVoEQQY_BgZcqOuQpqdMatvUJL3Dde__9tReuDALV8kJz_l63xDygtE9o0y-7ffmrt8XlEqM95TzR2THaK1yqYR4THaU0iKvFOUX5DLGHkNZVPIpuWCq4LWsxY78uRlnH5KZLGS-y6wf5wESZAEOJtplMMH9Nsn5KXNTNuMNphSze5fuMmMXBMejtya0zgxIdCbYf3AKYBK0GzhDQNRM4JeIHYKfTDginSAcsBzyz8iTzgwRnp_OK_Lj08fv11_y26-fb64_3OZWSJHyhq4biaoVktlWlmXVME6NUtK2YKSyqu0qzngtKtU1sqpMYS2vy7KxtBKS8yvyZqs7B_9rgZj06KKFYdiG07KqOediBV89AHu_hAln06ykQqLIbKXYRtngYwzQ6Tm4EZfTjOrVId1rdEivDq1P6BDmvDxVXpoR2nPGyRIEXp8ANMAMXUBvXDxzdU1lrVbu3cYBCnZwEHS06I6F1gWwSbfe_XeM9w-y7eAmhw1_whHieVsdC031t1X49SdRSWm9yvQX3JXFZg</recordid><startdate>20070201</startdate><enddate>20070201</enddate><creator>Kalarus, Zbigniew, MD</creator><creator>Lenarczyk, Radosław, MD</creator><creator>Kowalczyk, Jacek, MD</creator><creator>Kowalski, Oskar, MD</creator><creator>Gąsior, Mariusz, MD</creator><creator>Wąs, Tomasz, MD</creator><creator>Zębik, Tadeusz, MD</creator><creator>Krupa, Hubert, MD</creator><creator>Chodór, Piotr, MD</creator><creator>Poloński, Lech, MD, PhD</creator><creator>Zembala, Marian, MD, PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20070201</creationdate><title>Importance of complete revascularization in patients with acute myocardial infarction treated with percutaneous coronary intervention</title><author>Kalarus, Zbigniew, MD ; Lenarczyk, Radosław, MD ; Kowalczyk, Jacek, MD ; Kowalski, Oskar, MD ; Gąsior, Mariusz, MD ; Wąs, Tomasz, MD ; Zębik, Tadeusz, MD ; Krupa, Hubert, MD ; Chodór, Piotr, MD ; Poloński, Lech, MD, PhD ; Zembala, Marian, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-b0000248d461cd6558b130a776cdea67c7df83139487fb688a2cc3955bc084633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Angioplasty, Balloon, Coronary</topic><topic>Biological and medical sciences</topic><topic>Cardiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Coronary heart disease</topic><topic>Coronary vessels</topic><topic>Diseases of the cardiovascular system</topic><topic>Female</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Myocardial Infarction - therapy</topic><topic>Prognosis</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kalarus, Zbigniew, MD</creatorcontrib><creatorcontrib>Lenarczyk, Radosław, MD</creatorcontrib><creatorcontrib>Kowalczyk, Jacek, MD</creatorcontrib><creatorcontrib>Kowalski, Oskar, MD</creatorcontrib><creatorcontrib>Gąsior, Mariusz, MD</creatorcontrib><creatorcontrib>Wąs, Tomasz, MD</creatorcontrib><creatorcontrib>Zębik, Tadeusz, MD</creatorcontrib><creatorcontrib>Krupa, Hubert, MD</creatorcontrib><creatorcontrib>Chodór, Piotr, MD</creatorcontrib><creatorcontrib>Poloński, Lech, MD, PhD</creatorcontrib><creatorcontrib>Zembala, Marian, MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kalarus, Zbigniew, MD</au><au>Lenarczyk, Radosław, MD</au><au>Kowalczyk, Jacek, MD</au><au>Kowalski, Oskar, MD</au><au>Gąsior, Mariusz, MD</au><au>Wąs, Tomasz, MD</au><au>Zębik, Tadeusz, MD</au><au>Krupa, Hubert, MD</au><au>Chodór, Piotr, MD</au><au>Poloński, Lech, MD, PhD</au><au>Zembala, Marian, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Importance of complete revascularization in patients with acute myocardial infarction treated with percutaneous coronary intervention</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>2007-02-01</date><risdate>2007</risdate><volume>153</volume><issue>2</issue><spage>304</spage><epage>312</epage><pages>304-312</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><coden>AHJOA2</coden><abstract>Background The role of incomplete revascularization (ICR) in patients with acute myocardial infarction (AMI) is controversial. We evaluated the impact of ICR on short- and long-term outcome in patients with AMI and multivessel disease (MVD) treated with percutaneous coronary interventions (PCI) during index hospital stay. Methods Single-center observational study covered 798 patients with MVD selected from 1486 consecutive patients with AMI treated with PCI. At discharge, 605 (75.8%) of the patients still had at least 1 diseased artery (ICR group); in 193, complete revascularization (CR) has been achieved (CR group). Any-cause mortality rate and major adverse cardiac events (MACE) during hospitalization, within a follow-up period of 30 days and 29.7 months, were compared between both groups in the whole population and within the high-risk subgroups. Propensity model to predict the probability of CR according to 16 variables was used. Results Mortality and MACE rates were significantly higher in ICR group than among completely revascularized subjects during short- and long-term observation (remote mortality 18.5% vs 7.2%, MACE 53.1% vs 24.3%, both P < .001). Higher mortality rate was also observed within the subgroups with diabetes (25.2% vs 4.8%), renal dysfunction (44.1% vs 13.8%), and lowered ejection fraction (26.5% vs 10.5%, all P < .05). Propensity-adjusted multivariate analysis showed that ICR was a significant and strong predictor of remote death (propensity-adjusted hazard ratio 2.01, 95% CI 1.71-2.31, P = .02) and MACE (hazard ratio 2.08, 95% CI 1.90-2.26, P < .001). Conclusions Incomplete revascularization is a strong and independent risk factor of death and MACE in patients with AMI treated with PCI.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>17239694</pmid><doi>10.1016/j.ahj.2006.10.033</doi><tpages>9</tpages></addata></record> |
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subjects | Angioplasty, Balloon, Coronary Biological and medical sciences Cardiology Cardiology. Vascular system Cardiovascular Coronary heart disease Coronary vessels Diseases of the cardiovascular system Female Heart Heart attacks Hospitalization Humans Male Medical sciences Middle Aged Mortality Myocardial Infarction - therapy Prognosis Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Time Factors Treatment Outcome |
title | Importance of complete revascularization in patients with acute myocardial infarction treated with percutaneous coronary intervention |
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