SINE elements of Entamoeba dispar
Entamoeba histolytica and E. dispar are closely related protozoan parasites; the former causes clinical amoebiasis in humans while the latter appears to be non-pathogenic. The molecular biology of E. histolytica shows a number of unusual features, one of which is the abundance of polyadenylated but...
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| Veröffentlicht in: | Molecular and biochemical parasitology 2007-03, Vol.152 (1), p.47-52 |
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| container_title | Molecular and biochemical parasitology |
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| creator | Shire, Abdirashid M. Ackers, John P. |
| description | Entamoeba histolytica and E. dispar are closely related protozoan parasites; the former causes clinical amoebiasis in humans while the latter appears to be non-pathogenic. The molecular biology of E. histolytica shows a number of unusual features, one of which is the abundance of polyadenylated but apparently untranslatable mRNAs produced; many of these are the product of at least three families of SINEs (EhSINE1–3). Here we show that the genome of E. dispar contains numerous copies of a SINE element (EdSINE1) whose 5′- and 3′-ends are very similar to those of EhSINE1 but with a much less similar middle portion. Twelve out of 18 copies examined had target site duplications. In none out of six cases examined was there a SINE element in the homologous region of the E. histolytica genome but a single copy of EdSINE1 is present in E. histolytica where it is identified as EhSINE3. |
| doi_str_mv | 10.1016/j.molbiopara.2006.11.010 |
| format | Article |
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| language | eng |
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| subjects | Amino Acid Sequence Animals Blotting, Northern Blotting, Southern BspA-like protein DNA, Protozoan - chemistry DNA, Protozoan - genetics E. histolytica Entamoeba - genetics Entamoeba dispar Entamoeba histolytica Genome, Protozoan LINE Molecular Sequence Data Polymerase Chain Reaction RNA, Messenger - genetics RNA, Untranslated - genetics Sequence Analysis, DNA Sequence Homology, Nucleic Acid Short Interspersed Nucleotide Elements SINE |
| title | SINE elements of Entamoeba dispar |
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