Sex differences in the human olfactory system
The olfactory system (accessory) implicated in reproductive physiology and behavior in mammals is sexually dimorphic. These brain sex differences present two main characteristics: they are seen in neural circuits related to sexual behavior and sexual physiology and they take one of two opposite morp...
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| Veröffentlicht in: | Brain research 2006-10, Vol.1116 (1), p.103-111 |
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| creator | Garcia-Falgueras, Alicia Junque, Carme Giménez, Mónica Caldú, Xavier Segovia, Santiago Guillamon, Antonio |
| description | The olfactory system (accessory) implicated in reproductive physiology and behavior in mammals is sexually dimorphic. These brain sex differences present two main characteristics: they are seen in neural circuits related to sexual behavior and sexual physiology and they take one of two opposite morphological patterns (male
>
female or female
>
male). The present work reports sex differences in the olfactory system in a large homogeneous sample of men (40) and women (51) using of voxel-based morphology. Gray matter concentration showed sexual dimorphism in several olfactory regions. Women have a higher concentration in the orbitofrontal cortex involving Brodmann's areas 10, 11 and 25 and temporomedial cortex (bilateral hippocampus and right amygdala), as well as their left basal insular cortex. In contrast, men show a higher gray matter concentration in the left entorhinal cortex (Brodmann's area 28), right ventral pallidum, dorsal left insular cortex and a region of the orbitofrontal cortex (Brodmann's area 25). This study supports the hypothesis that the mammalian olfactory system is a sexually dimorphic network and provides a theoretical framework for the morphofunctional approach to sex differences in the human brain. |
| doi_str_mv | 10.1016/j.brainres.2006.07.115 |
| format | Article |
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>
female or female
>
male). The present work reports sex differences in the olfactory system in a large homogeneous sample of men (40) and women (51) using of voxel-based morphology. Gray matter concentration showed sexual dimorphism in several olfactory regions. Women have a higher concentration in the orbitofrontal cortex involving Brodmann's areas 10, 11 and 25 and temporomedial cortex (bilateral hippocampus and right amygdala), as well as their left basal insular cortex. In contrast, men show a higher gray matter concentration in the left entorhinal cortex (Brodmann's area 28), right ventral pallidum, dorsal left insular cortex and a region of the orbitofrontal cortex (Brodmann's area 25). This study supports the hypothesis that the mammalian olfactory system is a sexually dimorphic network and provides a theoretical framework for the morphofunctional approach to sex differences in the human brain.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2006.07.115</identifier><identifier>PMID: 16942757</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Amygdala - physiology ; Biological and medical sciences ; Cerebral Cortex - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Gender differences ; Globus Pallidus - physiology ; Hippocampus - physiology ; Human brain ; Humans ; Image Processing, Computer-Assisted ; Magnetic resonance image ; Magnetic Resonance Imaging ; Male ; Olfactory system ; Olfactory system and olfaction. Gustatory system and gustation ; Sex Characteristics ; Sex differences ; Sexual dimorphism ; Smell - physiology ; Vertebrates: nervous system and sense organs ; Voxel-based morphometry</subject><ispartof>Brain research, 2006-10, Vol.1116 (1), p.103-111</ispartof><rights>2006 Elsevier B.V.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-aad44d40e36b58998147c78ab6b468c31fae368694027f42c9d8e4dcf4ef8de03</citedby><cites>FETCH-LOGICAL-c427t-aad44d40e36b58998147c78ab6b468c31fae368694027f42c9d8e4dcf4ef8de03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006899306022840$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18179088$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16942757$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garcia-Falgueras, Alicia</creatorcontrib><creatorcontrib>Junque, Carme</creatorcontrib><creatorcontrib>Giménez, Mónica</creatorcontrib><creatorcontrib>Caldú, Xavier</creatorcontrib><creatorcontrib>Segovia, Santiago</creatorcontrib><creatorcontrib>Guillamon, Antonio</creatorcontrib><title>Sex differences in the human olfactory system</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The olfactory system (accessory) implicated in reproductive physiology and behavior in mammals is sexually dimorphic. These brain sex differences present two main characteristics: they are seen in neural circuits related to sexual behavior and sexual physiology and they take one of two opposite morphological patterns (male
>
female or female
>
male). The present work reports sex differences in the olfactory system in a large homogeneous sample of men (40) and women (51) using of voxel-based morphology. Gray matter concentration showed sexual dimorphism in several olfactory regions. Women have a higher concentration in the orbitofrontal cortex involving Brodmann's areas 10, 11 and 25 and temporomedial cortex (bilateral hippocampus and right amygdala), as well as their left basal insular cortex. In contrast, men show a higher gray matter concentration in the left entorhinal cortex (Brodmann's area 28), right ventral pallidum, dorsal left insular cortex and a region of the orbitofrontal cortex (Brodmann's area 25). This study supports the hypothesis that the mammalian olfactory system is a sexually dimorphic network and provides a theoretical framework for the morphofunctional approach to sex differences in the human brain.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Amygdala - physiology</subject><subject>Biological and medical sciences</subject><subject>Cerebral Cortex - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gender differences</subject><subject>Globus Pallidus - physiology</subject><subject>Hippocampus - physiology</subject><subject>Human brain</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Magnetic resonance image</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Olfactory system</subject><subject>Olfactory system and olfaction. Gustatory system and gustation</subject><subject>Sex Characteristics</subject><subject>Sex differences</subject><subject>Sexual dimorphism</subject><subject>Smell - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Voxel-based morphometry</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotlb_QtmL3nZNdtN83JTiFxQ8qOeQTSY0ZT9qshX7701ppceehmGemXl5EJoSXBBM2P2qqIP2XYBYlBizAvOCkNkZGhPBy5yVFJ-jMU6TXEhZjdBVjKvUVpXEl2hEmKQln_Exyj_gN7PeOQjQGYiZ77JhCdly0-ou6xunzdCHbRa3cYD2Gl043US4OdQJ-np--py_5ov3l7f54yI36eyQa20ptRRDxepZ-i8I5YYLXbOaMmEq4nQaiRQCl9zR0kgrgFrjKDhhAVcTdLe_uw799wbioFofDTSN7qDfRMWErIik8iRIZCUoFjuQ7UET-hgDOLUOvtVhqwhWO6Nqpf6Nqp1RhblKRtPi9PBhU7dgj2sHhQm4PQA6Gt24oDvj45EThEssROIe9hwkcT8egorG75xbH8AMyvb-VJY_PL-W2A</recordid><startdate>20061020</startdate><enddate>20061020</enddate><creator>Garcia-Falgueras, Alicia</creator><creator>Junque, Carme</creator><creator>Giménez, Mónica</creator><creator>Caldú, Xavier</creator><creator>Segovia, Santiago</creator><creator>Guillamon, Antonio</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20061020</creationdate><title>Sex differences in the human olfactory system</title><author>Garcia-Falgueras, Alicia ; Junque, Carme ; Giménez, Mónica ; Caldú, Xavier ; Segovia, Santiago ; Guillamon, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-aad44d40e36b58998147c78ab6b468c31fae368694027f42c9d8e4dcf4ef8de03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Amygdala - physiology</topic><topic>Biological and medical sciences</topic><topic>Cerebral Cortex - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gender differences</topic><topic>Globus Pallidus - physiology</topic><topic>Hippocampus - physiology</topic><topic>Human brain</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Magnetic resonance image</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Olfactory system</topic><topic>Olfactory system and olfaction. Gustatory system and gustation</topic><topic>Sex Characteristics</topic><topic>Sex differences</topic><topic>Sexual dimorphism</topic><topic>Smell - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Voxel-based morphometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garcia-Falgueras, Alicia</creatorcontrib><creatorcontrib>Junque, Carme</creatorcontrib><creatorcontrib>Giménez, Mónica</creatorcontrib><creatorcontrib>Caldú, Xavier</creatorcontrib><creatorcontrib>Segovia, Santiago</creatorcontrib><creatorcontrib>Guillamon, Antonio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garcia-Falgueras, Alicia</au><au>Junque, Carme</au><au>Giménez, Mónica</au><au>Caldú, Xavier</au><au>Segovia, Santiago</au><au>Guillamon, Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex differences in the human olfactory system</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2006-10-20</date><risdate>2006</risdate><volume>1116</volume><issue>1</issue><spage>103</spage><epage>111</epage><pages>103-111</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The olfactory system (accessory) implicated in reproductive physiology and behavior in mammals is sexually dimorphic. These brain sex differences present two main characteristics: they are seen in neural circuits related to sexual behavior and sexual physiology and they take one of two opposite morphological patterns (male
>
female or female
>
male). The present work reports sex differences in the olfactory system in a large homogeneous sample of men (40) and women (51) using of voxel-based morphology. Gray matter concentration showed sexual dimorphism in several olfactory regions. Women have a higher concentration in the orbitofrontal cortex involving Brodmann's areas 10, 11 and 25 and temporomedial cortex (bilateral hippocampus and right amygdala), as well as their left basal insular cortex. In contrast, men show a higher gray matter concentration in the left entorhinal cortex (Brodmann's area 28), right ventral pallidum, dorsal left insular cortex and a region of the orbitofrontal cortex (Brodmann's area 25). This study supports the hypothesis that the mammalian olfactory system is a sexually dimorphic network and provides a theoretical framework for the morphofunctional approach to sex differences in the human brain.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>16942757</pmid><doi>10.1016/j.brainres.2006.07.115</doi><tpages>9</tpages></addata></record> |
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| subjects | Adolescent Adult Amygdala - physiology Biological and medical sciences Cerebral Cortex - physiology Female Fundamental and applied biological sciences. Psychology Gender differences Globus Pallidus - physiology Hippocampus - physiology Human brain Humans Image Processing, Computer-Assisted Magnetic resonance image Magnetic Resonance Imaging Male Olfactory system Olfactory system and olfaction. Gustatory system and gustation Sex Characteristics Sex differences Sexual dimorphism Smell - physiology Vertebrates: nervous system and sense organs Voxel-based morphometry |
| title | Sex differences in the human olfactory system |
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