TiCl4/t-BuNH2-Promoted Hydroamination/Annulation of δ-Keto-acetylenes:  Synthesis of Novel Pyrrolo[1,2-a]indol-2-carbaldehydes

An original TiCl4/t-BuNH2-mediated hydroamination/annulation domino reaction of δ-keto-acetylenes is described. The synthesis of pyrrolo[1,2-a]indole-2-carbaldehydes, starting from 2-carbonyl-1-propargyl-1H-indoles runs under mild reaction conditions. A conceivable mechanism is also discussed. TiCl4...

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Veröffentlicht in:	Organic letters 2006-10, Vol.8 (21), p.4839-4842
Hauptverfasser:	Abbiati, Giorgio, Casoni, Alessandro, Canevari, Valentina, Nava, Donatella, Rossi, Elisabetta
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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