Expression and Functional Characterization of the Cancer-related Serine Protease, Human Tissue Kallikrein 14

Human tissue kallikrein 14 (KLK14) is a novel extracellular serine protease. Clinical data link KLK14 expression to several diseases, primarily cancer; however, little is known of its (patho)-physiological role. To functionally characterize KLK14, we expressed and purified recombinant KLK14 in matur...

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Veröffentlicht in:	The Journal of biological chemistry 2007-01, Vol.282 (4), p.2405-2422
Hauptverfasser:	Borgoño, Carla A., Michael, Iacovos P., Shaw, Julie L.V., Luo, Liu-Ying, Ghosh, Manik C., Soosaipillai, Antoninus, Grass, Linda, Katsaros, Dionyssios, Diamandis, Eleftherios P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biomarkers, Tumor Cartilage - metabolism Enzyme Activation - drug effects Extracellular Matrix Proteins - metabolism Female Humans Immunoassay Kallikreins - analysis Kallikreins - antagonists & inhibitors Kallikreins - metabolism Male Mice Mice, Inbred BALB C Models, Molecular Molecular Sequence Data Neovascularization, Pathologic Organ Specificity Prostatic Neoplasms - blood Prostatic Neoplasms - enzymology Rabbits Recombinant Proteins - metabolism Serine Endopeptidases - analysis Serine Endopeptidases - metabolism Serine Proteinase Inhibitors - pharmacology Substrate Specificity
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