Toll-like Receptor 9 Triggers an Innate Immune Response to Helper-dependent Adenoviral Vectors

A major obstacle to the clinical application of systemic adenoviral gene replacement therapy is the host innate immune response. Although recent studies have attempted to characterize the cellular basis for this response to systemically administered helper-dependent adenoviral vector (HD-Ad), the un...

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Veröffentlicht in:	Molecular therapy 2007-02, Vol.15 (2), p.378-385
Hauptverfasser:	Cerullo, Vincenzo, Seiler, Michael P, Mane, Viraj, Brunetti-Pierri, Nicola, Clarke, Christian, Bertin, Terry K, Rodgers, John R, Lee, Brendan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviruses Animals Cells Cytokines Cytokines - metabolism Cytomegalovirus Cytotoxicity Drug dosages Female Gene therapy Genetic Vectors - genetics Hemophilia Herpes viruses Immunity, Innate - immunology Immunoassay - methods Kinases Macrophages, Peritoneal - cytology Macrophages, Peritoneal - immunology Macrophages, Peritoneal - metabolism Mice Mice, Inbred C57BL Pattern recognition Proteins Reverse Transcriptase Polymerase Chain Reaction Toll-Like Receptor 9 - deficiency Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - physiology Transfection Tumor necrosis factor-TNF Vectors (Biology) Viral infections
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