Generation of Simian-Tropic HIV-1 by Restriction Factor Evasion

Because HIV-1 does not infect most nonhuman primates, animal modeling of human HIV infection and AIDS has primarily consisted of experimentally infecting macaques with related simian immunodeficiency viruses (SIVMAC). However, the usefulness of such models is limited by the substantial divergence be...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2006-10, Vol.314 (5796), p.95-95
Hauptverfasser:	Hatziioannou, Theodora, Princiotta, Michael, Piatak, Michael Jr, Yuan, Fang, Zhang, Fengwen, Lifson, Jeffrey D, Bieniasz, Paul D
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Animal diseases Animals Biological and medical sciences Brevia Capsid Proteins - genetics Cell Line Cell lines Cloning, Molecular Cytopathogenic Effect, Viral Disease Models, Animal General aspects Genes, vif Genomes HIV HIV 1 HIV Infections HIV-1 - genetics HIV-1 - physiology Human immunodeficiency virus Human immunodeficiency virus 1 Humans Infections Lentivirus Lymphocytes - virology Macaca mulatta Medical research Medical sciences Medical treatment Monkeys & apes Recombination, Genetic Simian Immunodeficiency Virus - genetics T lymphocytes T-Lymphocytes - virology Vaccines Virus Replication Viruses
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