West Nile virus
Summary West Nile virus is a mosquito-borne flavivirus originally isolated in 1937 from the blood of a febrile woman in the West Nile province of Uganda. The virus is widely distributed in Africa, Europe, Australia, and Asia, and, since 1999, it has spread rapidly throughout the western hemisphere,...
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| Veröffentlicht in: | Lancet neurology 2007-02, Vol.6 (2), p.171-181 |
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| container_title | Lancet neurology |
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| creator | Kramer, Laura D, PhD Li, Jun, MD Shi, Pei-Yong, PhD |
| description | Summary West Nile virus is a mosquito-borne flavivirus originally isolated in 1937 from the blood of a febrile woman in the West Nile province of Uganda. The virus is widely distributed in Africa, Europe, Australia, and Asia, and, since 1999, it has spread rapidly throughout the western hemisphere, including the USA, Canada, Mexico, and the Caribbean and into parts of Central and South America. Before 1994, outbreaks of West Nile virus were sporadic and occurred primarily in the Mediterranean region, Africa, and east Europe. Since 1994, outbreaks have occurred with a higher incidence of severe human disease, particularly affecting the nervous system. In North America, the virus has caused meningitis, encephalitis, and poliomyelitis, resulting in significant morbidity and mortality. The goal of this Review is to highlight recent advances in our understanding of West Nile virus virology, ecology, clinical disease, diagnosis, and development of potential vaccines and antiviral therapies. |
| doi_str_mv | 10.1016/S1474-4422(07)70030-3 |
| format | Article |
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The virus is widely distributed in Africa, Europe, Australia, and Asia, and, since 1999, it has spread rapidly throughout the western hemisphere, including the USA, Canada, Mexico, and the Caribbean and into parts of Central and South America. Before 1994, outbreaks of West Nile virus were sporadic and occurred primarily in the Mediterranean region, Africa, and east Europe. Since 1994, outbreaks have occurred with a higher incidence of severe human disease, particularly affecting the nervous system. In North America, the virus has caused meningitis, encephalitis, and poliomyelitis, resulting in significant morbidity and mortality. 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The virus is widely distributed in Africa, Europe, Australia, and Asia, and, since 1999, it has spread rapidly throughout the western hemisphere, including the USA, Canada, Mexico, and the Caribbean and into parts of Central and South America. Before 1994, outbreaks of West Nile virus were sporadic and occurred primarily in the Mediterranean region, Africa, and east Europe. Since 1994, outbreaks have occurred with a higher incidence of severe human disease, particularly affecting the nervous system. In North America, the virus has caused meningitis, encephalitis, and poliomyelitis, resulting in significant morbidity and mortality. 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Li, Jun, MD ; Shi, Pei-Yong, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-4a13addc256c5df6b5770275041bc4c939526804b17113565e0b61361524610a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Bird migration</topic><topic>Blood & organ donations</topic><topic>Blood transfusions</topic><topic>Disease Outbreaks</topic><topic>Encephalitis</topic><topic>Epidemics</topic><topic>Genomes</topic><topic>Humans</topic><topic>Kinases</topic><topic>Magnetic Resonance Imaging</topic><topic>Meningitis</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Mosquitoes</topic><topic>Neurology</topic><topic>Phylogenetics</topic><topic>Proteins</topic><topic>Virology</topic><topic>West Nile Fever - epidemiology</topic><topic>West Nile Fever - genetics</topic><topic>West Nile Fever - pathology</topic><topic>West Nile Fever - therapy</topic><topic>West Nile virus</topic><topic>West Nile virus - genetics</topic><topic>West Nile virus - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kramer, Laura D, PhD</creatorcontrib><creatorcontrib>Li, Jun, MD</creatorcontrib><creatorcontrib>Shi, Pei-Yong, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Lancet Titles</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Lancet neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kramer, Laura D, PhD</au><au>Li, Jun, MD</au><au>Shi, Pei-Yong, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>West Nile virus</atitle><jtitle>Lancet neurology</jtitle><addtitle>Lancet Neurol</addtitle><date>2007-02-01</date><risdate>2007</risdate><volume>6</volume><issue>2</issue><spage>171</spage><epage>181</epage><pages>171-181</pages><issn>1474-4422</issn><eissn>1474-4465</eissn><coden>LANCAO</coden><abstract>Summary West Nile virus is a mosquito-borne flavivirus originally isolated in 1937 from the blood of a febrile woman in the West Nile province of Uganda. 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| identifier | ISSN: 1474-4422 |
| ispartof | Lancet neurology, 2007-02, Vol.6 (2), p.171-181 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Antiviral Agents - therapeutic use Bird migration Blood & organ donations Blood transfusions Disease Outbreaks Encephalitis Epidemics Genomes Humans Kinases Magnetic Resonance Imaging Meningitis Morbidity Mortality Mosquitoes Neurology Phylogenetics Proteins Virology West Nile Fever - epidemiology West Nile Fever - genetics West Nile Fever - pathology West Nile Fever - therapy West Nile virus West Nile virus - genetics West Nile virus - isolation & purification |
| title | West Nile virus |
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