Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells

To identify cancer-specific targets, we have conducted a synthetic lethal screen using a small interfering RNA (siRNA) library targeting ∼4,000 individual genes for enhanced killing in the DLD-1 colon carcinoma cell line that expresses an activated copy of the K-Ras oncogene. We found that siRNAs ta...

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Veröffentlicht in:	Molecular cancer therapeutics 2007-01, Vol.6 (1), p.269-276
Hauptverfasser:	Sarthy, Aparna V, Morgan-Lappe, Susan E, Zakula, Dorothy, Vernetti, Lawrence, Schurdak, Mark, Packer, Jeremy C L, Anderson, Mark G, Shirasawa, Senji, Sasazuki, Takehiko, Fesik, Stephen W
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Apoptosis Cell Death Cell Survival Cell Transformation, Neoplastic - pathology Clone Cells G2 Phase Genes, Neoplasm Genes, ras Humans Inhibitor of Apoptosis Proteins isogenic cancer cell lines K-Ras Microtubule-Associated Proteins - deficiency Microtubule-Associated Proteins - metabolism Mitosis Mutant Proteins - metabolism Neoplasm Proteins - deficiency Neoplasm Proteins - metabolism Polyploidy RNA interference RNA, Small Interfering - metabolism siRNA survivin
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