Osteopontin: a bridge between bone and blood

Summary The production of mature blood cells within the bone marrow (BM) is attributed to a pool of haemopoietic stem cells (HSC). It is now evident that HSC reside preferentially at the endosteal region within the BM where bone‐lining osteoblasts are a key cellular component of the HSC niche that d...

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Veröffentlicht in:	British journal of haematology 2006-09, Vol.134 (5), p.467-474
Hauptverfasser:	Haylock, David N., Nilsson, Susan K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences bone marrow haemopoietic stem cells Hematologic and hematopoietic diseases Hematologic Neoplasms - metabolism Hematologic Neoplasms - pathology Hematopoiesis - physiology Hematopoietic Stem Cells - cytology Humans Integrin beta1 - metabolism Medical sciences niche Osteoblasts - pathology Osteoblasts - physiology Osteopontin Sialoglycoproteins - physiology
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