Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

Protein ubiquitination is a common form of post-translational modification that regulates a broad spectrum of protein substrates in diverse cellular pathways. Through a three-enzyme (E1-E2-E3) cascade, the attachment of ubiquitin to proteins is catalysed by the E3 ubiquitin ligase, which is best rep...

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Veröffentlicht in:	Nature 2006-10, Vol.443 (7111), p.590-593
Hauptverfasser:	Moon, Randall T, Zheng, Ning, Yi, Xianhua, Angers, Stephane, MacCoss, Michael J, Li, Ti
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Binding Sites Biological and medical sciences Carrier Proteins - chemistry Carrier Proteins - metabolism Cellular biology Crystallography, X-Ray Cullin Proteins - chemistry Cullin Proteins - metabolism Deoxyribonucleic acid DNA DNA repair DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Enzymes Fundamental and applied biological sciences. Psychology Humans Interactions. Associations Intermolecular phenomena Mass spectrometry Models, Molecular Molecular biophysics Molecular Sequence Data Molecular structure Pliability Protein Binding Protein Structure, Quaternary Proteins Proteomics Structure-Activity Relationship Substrate Specificity Substrates Ubiquitin - metabolism Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - metabolism Viruses Yeasts
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