Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases
Olfactory function is affected in different neurodegenerative diseases. Recently, it has been found that some hereditary ataxias are also associated with significant olfactory impairment. However, the initial findings did not examine the nature of the olfactory impairment associated with these ataxi...
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| Veröffentlicht in: | Journal of neurology 2006-09, Vol.253 (9), p.1165-1169 |
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| creator | VELAZQUEZ-PEREZ, Luis FERNANDEZ-RUIZ, Juan DIAZ, Rosalinda PEREZ-GONZALEZ, Ruth CANALES OCHOA, Nalia SANCHEZ CRUZ, Gilberto ENRIQUE ALMAGUER MEDEROS, Luis GONGORA, Edilberto Martinez HUDSON, Robyn DRUCKER-COLIN, René |
| description | Olfactory function is affected in different neurodegenerative diseases. Recently, it has been found that some hereditary ataxias are also associated with significant olfactory impairment. However, the initial findings did not examine the nature of the olfactory impairment associated with these ataxias. In the present article the effect of spinocerebellar ataxia type 2 (SCA2) on olfactory function was studied in 53 SCA2 patients and 53 healthy control subjects from Holguín, Cuba. Several tests were applied to evaluate olfactory threshold, description, identification and discrimination. The results show significant impairment in SCA2 patients on all olfactory measurements, and the pattern of olfactory deficits found suggests that they have much in common with those reported for other neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. |
| doi_str_mv | 10.1007/s00415-006-0183-2 |
| format | Article |
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Recently, it has been found that some hereditary ataxias are also associated with significant olfactory impairment. However, the initial findings did not examine the nature of the olfactory impairment associated with these ataxias. In the present article the effect of spinocerebellar ataxia type 2 (SCA2) on olfactory function was studied in 53 SCA2 patients and 53 healthy control subjects from Holguín, Cuba. Several tests were applied to evaluate olfactory threshold, description, identification and discrimination. The results show significant impairment in SCA2 patients on all olfactory measurements, and the pattern of olfactory deficits found suggests that they have much in common with those reported for other neurodegenerative diseases such as Parkinson's and Alzheimer's diseases.</description><identifier>ISSN: 0340-5354</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-006-0183-2</identifier><identifier>PMID: 16609806</identifier><identifier>CODEN: JNRYA9</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adult ; Aged ; Ataxia ; Biological and medical sciences ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Disease ; Female ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Male ; Medical sciences ; Middle Aged ; Nervous system (semeiology, syndromes) ; Neurodegenerative Diseases - physiopathology ; Neurology ; Neuropsychological Tests ; Olfaction Disorders - diagnosis ; Olfaction Disorders - etiology ; Pattern Recognition, Physiological - physiology ; Psychiatric Status Rating Scales ; Sensory Thresholds - physiology ; Spinocerebellar Ataxias - complications ; Spinocerebellar Ataxias - diagnosis</subject><ispartof>Journal of neurology, 2006-09, Vol.253 (9), p.1165-1169</ispartof><rights>2007 INIST-CNRS</rights><rights>Steinkopff Verlag Darmstadt 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-400306001f9e485a127676be1def12b5d6a951f1b48d91b1d85db386459f337d3</citedby><cites>FETCH-LOGICAL-c356t-400306001f9e485a127676be1def12b5d6a951f1b48d91b1d85db386459f337d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18373601$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16609806$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VELAZQUEZ-PEREZ, Luis</creatorcontrib><creatorcontrib>FERNANDEZ-RUIZ, Juan</creatorcontrib><creatorcontrib>DIAZ, Rosalinda</creatorcontrib><creatorcontrib>PEREZ-GONZALEZ, Ruth</creatorcontrib><creatorcontrib>CANALES OCHOA, Nalia</creatorcontrib><creatorcontrib>SANCHEZ CRUZ, Gilberto</creatorcontrib><creatorcontrib>ENRIQUE ALMAGUER MEDEROS, Luis</creatorcontrib><creatorcontrib>GONGORA, Edilberto Martinez</creatorcontrib><creatorcontrib>HUDSON, Robyn</creatorcontrib><creatorcontrib>DRUCKER-COLIN, René</creatorcontrib><title>Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><description>Olfactory function is affected in different neurodegenerative diseases. Recently, it has been found that some hereditary ataxias are also associated with significant olfactory impairment. However, the initial findings did not examine the nature of the olfactory impairment associated with these ataxias. In the present article the effect of spinocerebellar ataxia type 2 (SCA2) on olfactory function was studied in 53 SCA2 patients and 53 healthy control subjects from Holguín, Cuba. Several tests were applied to evaluate olfactory threshold, description, identification and discrimination. The results show significant impairment in SCA2 patients on all olfactory measurements, and the pattern of olfactory deficits found suggests that they have much in common with those reported for other neurodegenerative diseases such as Parkinson's and Alzheimer's diseases.</description><subject>Adult</subject><subject>Aged</subject><subject>Ataxia</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Disease</subject><subject>Female</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurodegenerative Diseases - physiopathology</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Olfaction Disorders - diagnosis</subject><subject>Olfaction Disorders - etiology</subject><subject>Pattern Recognition, Physiological - physiology</subject><subject>Psychiatric Status Rating Scales</subject><subject>Sensory Thresholds - physiology</subject><subject>Spinocerebellar Ataxias - complications</subject><subject>Spinocerebellar Ataxias - diagnosis</subject><issn>0340-5354</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkU2L1EAQhhtR3HH1B3iRRtBbtCqd7nSOsvgFCx7Uc1NJKm4PSTp2d1zn35swAwue6lDP-1LFI8RLhHcIUL9PABXqAsAUgFYV5SNxwEqVBVa6eSwOoCootNLVlXiW0hEA7LZ4Kq7QGGgsmIPI3xc_h44jtzyOFCVl-utJ5tPCspRhHKjLIZ6knxbyceI5y3QX7pMkuVDOHGeZ_OT3aA4y5DuOcqJjiHLmNYaef_HMkbL_w7L3iSlxei6eDDQmfnGZ1-Lnp48_br4Ut98-f735cFt0SptcVAAKDAAODVdWE5a1qU3L2POAZat7Q43GAdvK9g222Fvdt8qa7cdBqbpX1-LtuXeJ4ffKKbvJp27_c-awJmdsU1qw9Qa-_g88hjXO222uRIu6NnqH8Ax1MaQUeXBL9BPFk0Nwuw939uE2H2734cot8-pSvLYT9w-Ji4ANeHMBKHU0DpHmzqcHzqpaGUD1Dy91k7Y</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>VELAZQUEZ-PEREZ, Luis</creator><creator>FERNANDEZ-RUIZ, Juan</creator><creator>DIAZ, Rosalinda</creator><creator>PEREZ-GONZALEZ, Ruth</creator><creator>CANALES OCHOA, Nalia</creator><creator>SANCHEZ CRUZ, Gilberto</creator><creator>ENRIQUE ALMAGUER MEDEROS, Luis</creator><creator>GONGORA, Edilberto Martinez</creator><creator>HUDSON, Robyn</creator><creator>DRUCKER-COLIN, René</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20060901</creationdate><title>Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases</title><author>VELAZQUEZ-PEREZ, Luis ; FERNANDEZ-RUIZ, Juan ; DIAZ, Rosalinda ; PEREZ-GONZALEZ, Ruth ; CANALES OCHOA, Nalia ; SANCHEZ CRUZ, Gilberto ; ENRIQUE ALMAGUER MEDEROS, Luis ; GONGORA, Edilberto Martinez ; HUDSON, Robyn ; DRUCKER-COLIN, René</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-400306001f9e485a127676be1def12b5d6a951f1b48d91b1d85db386459f337d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Ataxia</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Disease</topic><topic>Female</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurodegenerative Diseases - physiopathology</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Olfaction Disorders - diagnosis</topic><topic>Olfaction Disorders - etiology</topic><topic>Pattern Recognition, Physiological - physiology</topic><topic>Psychiatric Status Rating Scales</topic><topic>Sensory Thresholds - physiology</topic><topic>Spinocerebellar Ataxias - complications</topic><topic>Spinocerebellar Ataxias - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VELAZQUEZ-PEREZ, Luis</creatorcontrib><creatorcontrib>FERNANDEZ-RUIZ, Juan</creatorcontrib><creatorcontrib>DIAZ, Rosalinda</creatorcontrib><creatorcontrib>PEREZ-GONZALEZ, Ruth</creatorcontrib><creatorcontrib>CANALES OCHOA, Nalia</creatorcontrib><creatorcontrib>SANCHEZ CRUZ, Gilberto</creatorcontrib><creatorcontrib>ENRIQUE ALMAGUER MEDEROS, Luis</creatorcontrib><creatorcontrib>GONGORA, Edilberto Martinez</creatorcontrib><creatorcontrib>HUDSON, Robyn</creatorcontrib><creatorcontrib>DRUCKER-COLIN, René</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VELAZQUEZ-PEREZ, Luis</au><au>FERNANDEZ-RUIZ, Juan</au><au>DIAZ, Rosalinda</au><au>PEREZ-GONZALEZ, Ruth</au><au>CANALES OCHOA, Nalia</au><au>SANCHEZ CRUZ, Gilberto</au><au>ENRIQUE ALMAGUER MEDEROS, Luis</au><au>GONGORA, Edilberto Martinez</au><au>HUDSON, Robyn</au><au>DRUCKER-COLIN, René</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases</atitle><jtitle>Journal of neurology</jtitle><addtitle>J Neurol</addtitle><date>2006-09-01</date><risdate>2006</risdate><volume>253</volume><issue>9</issue><spage>1165</spage><epage>1169</epage><pages>1165-1169</pages><issn>0340-5354</issn><eissn>1432-1459</eissn><coden>JNRYA9</coden><abstract>Olfactory function is affected in different neurodegenerative diseases. Recently, it has been found that some hereditary ataxias are also associated with significant olfactory impairment. However, the initial findings did not examine the nature of the olfactory impairment associated with these ataxias. In the present article the effect of spinocerebellar ataxia type 2 (SCA2) on olfactory function was studied in 53 SCA2 patients and 53 healthy control subjects from Holguín, Cuba. Several tests were applied to evaluate olfactory threshold, description, identification and discrimination. The results show significant impairment in SCA2 patients on all olfactory measurements, and the pattern of olfactory deficits found suggests that they have much in common with those reported for other neurodegenerative diseases such as Parkinson's and Alzheimer's diseases.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>16609806</pmid><doi>10.1007/s00415-006-0183-2</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Ataxia Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurodegenerative Diseases - physiopathology Neurology Neuropsychological Tests Olfaction Disorders - diagnosis Olfaction Disorders - etiology Pattern Recognition, Physiological - physiology Psychiatric Status Rating Scales Sensory Thresholds - physiology Spinocerebellar Ataxias - complications Spinocerebellar Ataxias - diagnosis |
| title | Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases |
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