Viscolin, a new chalcone from Viscum coloratum, inhibits human neutrophil superoxide anion and elastase release via a cAMP-dependent pathway

The mistletoe Viscum coloratum is used in traditional Chinese medicine to treat inflammatory diseases. In this study, a cellular model in isolated human neutrophils, which are important in the pathogenesis of rheumatoid arthritis, chronic obstructive pulmonary disease, and other inflammatory disease...

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Veröffentlicht in:	Free radical biology & medicine 2006-11, Vol.41 (9), p.1433-1441
Hauptverfasser:	Hwang, Tsong-Long, Leu, Yann-Lii, Kao, Shu-Hui, Tang, Ming-Chi, Chang, Han-Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Biphenyl Compounds - pharmacology Calcium - metabolism cAMP Chemotaxis, Leukocyte Cyclic AMP - metabolism Cytosol - metabolism Elastase Humans N-Formylmethionine Leucyl-Phenylalanine - analogs & derivatives N-Formylmethionine Leucyl-Phenylalanine - pharmacology Neutrophil Neutrophils - drug effects Neutrophils - metabolism Pancreatic Elastase - metabolism Propane - analogs & derivatives Propane - pharmacology Signal Transduction - drug effects Superoxide Superoxides - metabolism Viscolin Viscum - chemistry Viscum - metabolism Viscum coloratum
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