Effect of eicosapentaenoic/docosahexaenoic fatty acids and soluble fibers on blood lipids of individuals classified into different levels of lipidemia
Abstract Objective This study evaluated the effect of a formulation containing eicosapentaenoic acid and docosahexaenoic acid combined with soluble fibers (β-glucan and guar gum) on fasting blood lipids used as coronary heart disease biomarkers of individuals classified into different levels of lipi...
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| Veröffentlicht in: | Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2007-02, Vol.23 (2), p.127-137 |
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| creator | Castro, Inar A., Ph.D Monteiro, Vânia C.B., M.D Barroso, Lúcia P., Ph.D Bertolami, Marcelo C., Ph.D |
| description | Abstract Objective This study evaluated the effect of a formulation containing eicosapentaenoic acid and docosahexaenoic acid combined with soluble fibers (β-glucan and guar gum) on fasting blood lipids used as coronary heart disease biomarkers of individuals classified into different levels of lipidemia by multivariate techniques. Methods Serum total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triacylglycerol, plasma glucose concentrations, body mass index, age, and waist circumference were determined in 99 healthy volunteers. Three clusters or subgroups were identified according to coronary heart disease risk levels. Within each cluster, individuals were randomly assigned to one of four experimental groups, with each group receiving samples of a functional formulation containing 460 mg of ω-3 polyunsaturated fatty acids and/or 580 mg of soluble fibers, and placebo to be consumed in one bottle per day (200 mL) for 6 wk. Results No significant changes were observed for triacylglycerol ( P = 0.281) and total cholesterol ( P = 0.082) concentrations across the three subgroups. Soluble dietary fibers improved the sensory quality of the formulation containing eicosapentaenoic acid and docosahexaenoic acid. The efficiency of cluster analysis to discriminate individuals in subgroups was confirmed by one-way analysis of variance ( P < 0.003). Conclusion The ω-3 polyunsaturated fatty acid supplementation equivalent to fish consumed 2.5 to 3 times per week by a functional food-containing soluble dietary fiber showed no beneficial result in terms of changes in blood lipids in individuals classified according to different levels of lipidemia. Small numbers of patients in each cluster and possibly the low dose of fish oil and soluble dietary fibers used in this study may have also contributed to the lack of these differences. Multivariate techniques proved to be a very efficient tool to solve the heterogeneity problem usually observed in human designs and to evaluate the results within subgroups categorized by n variables extracted from the same population. |
| doi_str_mv | 10.1016/j.nut.2006.11.006 |
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Methods Serum total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triacylglycerol, plasma glucose concentrations, body mass index, age, and waist circumference were determined in 99 healthy volunteers. Three clusters or subgroups were identified according to coronary heart disease risk levels. Within each cluster, individuals were randomly assigned to one of four experimental groups, with each group receiving samples of a functional formulation containing 460 mg of ω-3 polyunsaturated fatty acids and/or 580 mg of soluble fibers, and placebo to be consumed in one bottle per day (200 mL) for 6 wk. Results No significant changes were observed for triacylglycerol ( P = 0.281) and total cholesterol ( P = 0.082) concentrations across the three subgroups. Soluble dietary fibers improved the sensory quality of the formulation containing eicosapentaenoic acid and docosahexaenoic acid. The efficiency of cluster analysis to discriminate individuals in subgroups was confirmed by one-way analysis of variance ( P < 0.003). Conclusion The ω-3 polyunsaturated fatty acid supplementation equivalent to fish consumed 2.5 to 3 times per week by a functional food-containing soluble dietary fiber showed no beneficial result in terms of changes in blood lipids in individuals classified according to different levels of lipidemia. Small numbers of patients in each cluster and possibly the low dose of fish oil and soluble dietary fibers used in this study may have also contributed to the lack of these differences. Multivariate techniques proved to be a very efficient tool to solve the heterogeneity problem usually observed in human designs and to evaluate the results within subgroups categorized by n variables extracted from the same population.</description><identifier>ISSN: 0899-9007</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/j.nut.2006.11.006</identifier><identifier>PMID: 17234506</identifier><identifier>CODEN: NUTRER</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; beta-glucans ; Biological and medical sciences ; biomarkers ; Blood ; blood glucose ; blood lipids ; Body mass index ; Cardiovascular diseases ; Cholesterol ; cholesterol metabolism ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Cluster Analysis ; Coronary Disease - blood ; Coronary Disease - prevention & control ; dietary fat ; Dietary fiber ; Dietary Fiber - administration & dosage ; Dietary Fiber - therapeutic use ; Docosahexaenoic acid ; Docosahexaenoic Acids - administration & dosage ; Docosahexaenoic Acids - therapeutic use ; Double-Blind Method ; Eicosapentaenoic acid ; Eicosapentaenoic Acid - administration & dosage ; Eicosapentaenoic Acid - therapeutic use ; Fatty acids ; Feeding. Feeding behavior ; Female ; Fibers ; Fish oils ; Food, Fortified ; Functional foods ; Functional foods & nutraceuticals ; Fundamental and applied biological sciences. Psychology ; Gastroenterology and Hepatology ; guar gum ; health foods ; health promotion ; Health risks ; Heterogeneity ; high density lipoprotein ; human nutrition ; Humans ; hyperlipidemia ; Hyperlipidemias - diet therapy ; Lipids ; Lipids - blood ; low density lipoprotein ; Male ; Middle Aged ; Multivariate Analysis ; omega-3 fatty acids ; Polyunsaturated fatty acids ; Risk Factors ; Solubility ; Soluble dietary fibers ; soluble fiber ; Triacylglycerol ; triacylglycerols ; Triglycerides - blood ; Variance analysis ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; ω-3 Polyunsaturated fatty acid</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2007-02, Vol.23 (2), p.127-137</ispartof><rights>Elsevier Inc.</rights><rights>2007 Elsevier Inc.</rights><rights>2007 INIST-CNRS</rights><rights>Copyright Elsevier Limited Feb 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-bfb09fd13a227ba0ce2caa20c93de0791e47a4385183fb8d590d129dc69cbf233</citedby><cites>FETCH-LOGICAL-c488t-bfb09fd13a227ba0ce2caa20c93de0791e47a4385183fb8d590d129dc69cbf233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1644791329?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000,64390,64392,64394,72474</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19164013$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17234506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Castro, Inar A., Ph.D</creatorcontrib><creatorcontrib>Monteiro, Vânia C.B., M.D</creatorcontrib><creatorcontrib>Barroso, Lúcia P., Ph.D</creatorcontrib><creatorcontrib>Bertolami, Marcelo C., Ph.D</creatorcontrib><title>Effect of eicosapentaenoic/docosahexaenoic fatty acids and soluble fibers on blood lipids of individuals classified into different levels of lipidemia</title><title>Nutrition (Burbank, Los Angeles County, Calif.)</title><addtitle>Nutrition</addtitle><description>Abstract Objective This study evaluated the effect of a formulation containing eicosapentaenoic acid and docosahexaenoic acid combined with soluble fibers (β-glucan and guar gum) on fasting blood lipids used as coronary heart disease biomarkers of individuals classified into different levels of lipidemia by multivariate techniques. Methods Serum total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triacylglycerol, plasma glucose concentrations, body mass index, age, and waist circumference were determined in 99 healthy volunteers. Three clusters or subgroups were identified according to coronary heart disease risk levels. Within each cluster, individuals were randomly assigned to one of four experimental groups, with each group receiving samples of a functional formulation containing 460 mg of ω-3 polyunsaturated fatty acids and/or 580 mg of soluble fibers, and placebo to be consumed in one bottle per day (200 mL) for 6 wk. Results No significant changes were observed for triacylglycerol ( P = 0.281) and total cholesterol ( P = 0.082) concentrations across the three subgroups. Soluble dietary fibers improved the sensory quality of the formulation containing eicosapentaenoic acid and docosahexaenoic acid. The efficiency of cluster analysis to discriminate individuals in subgroups was confirmed by one-way analysis of variance ( P < 0.003). Conclusion The ω-3 polyunsaturated fatty acid supplementation equivalent to fish consumed 2.5 to 3 times per week by a functional food-containing soluble dietary fiber showed no beneficial result in terms of changes in blood lipids in individuals classified according to different levels of lipidemia. Small numbers of patients in each cluster and possibly the low dose of fish oil and soluble dietary fibers used in this study may have also contributed to the lack of these differences. Multivariate techniques proved to be a very efficient tool to solve the heterogeneity problem usually observed in human designs and to evaluate the results within subgroups categorized by n variables extracted from the same population.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>beta-glucans</subject><subject>Biological and medical sciences</subject><subject>biomarkers</subject><subject>Blood</subject><subject>blood glucose</subject><subject>blood lipids</subject><subject>Body mass index</subject><subject>Cardiovascular diseases</subject><subject>Cholesterol</subject><subject>cholesterol metabolism</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Cluster Analysis</subject><subject>Coronary Disease - blood</subject><subject>Coronary Disease - prevention & control</subject><subject>dietary fat</subject><subject>Dietary fiber</subject><subject>Dietary Fiber - administration & dosage</subject><subject>Dietary Fiber - therapeutic use</subject><subject>Docosahexaenoic acid</subject><subject>Docosahexaenoic Acids - administration & dosage</subject><subject>Docosahexaenoic Acids - therapeutic use</subject><subject>Double-Blind Method</subject><subject>Eicosapentaenoic acid</subject><subject>Eicosapentaenoic Acid - administration & dosage</subject><subject>Eicosapentaenoic Acid - therapeutic use</subject><subject>Fatty acids</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fibers</subject><subject>Fish oils</subject><subject>Food, Fortified</subject><subject>Functional foods</subject><subject>Functional foods & nutraceuticals</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology and Hepatology</subject><subject>guar gum</subject><subject>health foods</subject><subject>health promotion</subject><subject>Health risks</subject><subject>Heterogeneity</subject><subject>high density lipoprotein</subject><subject>human nutrition</subject><subject>Humans</subject><subject>hyperlipidemia</subject><subject>Hyperlipidemias - diet therapy</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>low density lipoprotein</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>omega-3 fatty acids</subject><subject>Polyunsaturated fatty acids</subject><subject>Risk Factors</subject><subject>Solubility</subject><subject>Soluble dietary fibers</subject><subject>soluble fiber</subject><subject>Triacylglycerol</subject><subject>triacylglycerols</subject><subject>Triglycerides - blood</subject><subject>Variance analysis</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>ω-3 Polyunsaturated fatty acid</subject><issn>0899-9007</issn><issn>1873-1244</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9ks2KFDEQxxtR3HX1AbxoQPQ2s5V0T3cHQZBl_YAFD-ueQzqpaMZMMibdg_MiPq_VOwMDe_BUpPL713dVveSw5MDby_UyTuNSALRLzpdkHlXnvO_qBRdN87g6h17KhQTozqpnpawBgMtWPq3OeCfqZgXtefX32jk0I0uOoTep6C3GUWNM3lzaNDt-4p_Dmzk9jnumjbeF6WhZSWEaAjLnB8yFpciGkJJlwW9nhEL6aP3O20mHwkzQpXjn0ZJ7TMx6ypwpGwu4w3DP3ytx4_Xz6okjEb442ovq7tP196svi5tvn79efbxZmKbvx8XgBpDO8loL0Q0aDAqjtQAja4vQSY5Np5u6X_G-dkNvVxIsF9KaVprBibq-qN4d4m5z-j1hGdXGF4Mh6IhpKqrtpWi7mhP45gG4TlOOVJvibdNQqlpIoviBMjmVktGpbfYbnfeKg5pXptaKVqbmlSnOFRnSvDpGnoYN2pPiuCMC3h4BXYwOLutofDlxkgoAPvfy-sA5nZT-kYm5uxX0QwfQNCvRE_H-QNC4cecxq2I8RoPWZzoCZZP_b6EfHqhN8NFTSb9wj-U0D1WEAnU7X998fNAC1JK6-QdqM9Ti</recordid><startdate>20070201</startdate><enddate>20070201</enddate><creator>Castro, Inar A., Ph.D</creator><creator>Monteiro, Vânia C.B., M.D</creator><creator>Barroso, Lúcia P., Ph.D</creator><creator>Bertolami, Marcelo C., Ph.D</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20070201</creationdate><title>Effect of eicosapentaenoic/docosahexaenoic fatty acids and soluble fibers on blood lipids of individuals classified into different levels of lipidemia</title><author>Castro, Inar A., Ph.D ; Monteiro, Vânia C.B., M.D ; Barroso, Lúcia P., Ph.D ; Bertolami, Marcelo C., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-bfb09fd13a227ba0ce2caa20c93de0791e47a4385183fb8d590d129dc69cbf233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>beta-glucans</topic><topic>Biological and medical sciences</topic><topic>biomarkers</topic><topic>Blood</topic><topic>blood glucose</topic><topic>blood lipids</topic><topic>Body mass index</topic><topic>Cardiovascular diseases</topic><topic>Cholesterol</topic><topic>cholesterol metabolism</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Cluster Analysis</topic><topic>Coronary Disease - blood</topic><topic>Coronary Disease - prevention & control</topic><topic>dietary fat</topic><topic>Dietary fiber</topic><topic>Dietary Fiber - administration & dosage</topic><topic>Dietary Fiber - therapeutic use</topic><topic>Docosahexaenoic acid</topic><topic>Docosahexaenoic Acids - administration & dosage</topic><topic>Docosahexaenoic Acids - therapeutic use</topic><topic>Double-Blind Method</topic><topic>Eicosapentaenoic acid</topic><topic>Eicosapentaenoic Acid - administration & dosage</topic><topic>Eicosapentaenoic Acid - therapeutic use</topic><topic>Fatty acids</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fibers</topic><topic>Fish oils</topic><topic>Food, Fortified</topic><topic>Functional foods</topic><topic>Functional foods & nutraceuticals</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology and Hepatology</topic><topic>guar gum</topic><topic>health foods</topic><topic>health promotion</topic><topic>Health risks</topic><topic>Heterogeneity</topic><topic>high density lipoprotein</topic><topic>human nutrition</topic><topic>Humans</topic><topic>hyperlipidemia</topic><topic>Hyperlipidemias - diet therapy</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>low density lipoprotein</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>omega-3 fatty acids</topic><topic>Polyunsaturated fatty acids</topic><topic>Risk Factors</topic><topic>Solubility</topic><topic>Soluble dietary fibers</topic><topic>soluble fiber</topic><topic>Triacylglycerol</topic><topic>triacylglycerols</topic><topic>Triglycerides - blood</topic><topic>Variance analysis</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>ω-3 Polyunsaturated fatty acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Castro, Inar A., Ph.D</creatorcontrib><creatorcontrib>Monteiro, Vânia C.B., M.D</creatorcontrib><creatorcontrib>Barroso, Lúcia P., Ph.D</creatorcontrib><creatorcontrib>Bertolami, Marcelo C., Ph.D</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>Proquest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Castro, Inar A., Ph.D</au><au>Monteiro, Vânia C.B., M.D</au><au>Barroso, Lúcia P., Ph.D</au><au>Bertolami, Marcelo C., Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of eicosapentaenoic/docosahexaenoic fatty acids and soluble fibers on blood lipids of individuals classified into different levels of lipidemia</atitle><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle><addtitle>Nutrition</addtitle><date>2007-02-01</date><risdate>2007</risdate><volume>23</volume><issue>2</issue><spage>127</spage><epage>137</epage><pages>127-137</pages><issn>0899-9007</issn><eissn>1873-1244</eissn><coden>NUTRER</coden><abstract>Abstract Objective This study evaluated the effect of a formulation containing eicosapentaenoic acid and docosahexaenoic acid combined with soluble fibers (β-glucan and guar gum) on fasting blood lipids used as coronary heart disease biomarkers of individuals classified into different levels of lipidemia by multivariate techniques. Methods Serum total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triacylglycerol, plasma glucose concentrations, body mass index, age, and waist circumference were determined in 99 healthy volunteers. Three clusters or subgroups were identified according to coronary heart disease risk levels. Within each cluster, individuals were randomly assigned to one of four experimental groups, with each group receiving samples of a functional formulation containing 460 mg of ω-3 polyunsaturated fatty acids and/or 580 mg of soluble fibers, and placebo to be consumed in one bottle per day (200 mL) for 6 wk. Results No significant changes were observed for triacylglycerol ( P = 0.281) and total cholesterol ( P = 0.082) concentrations across the three subgroups. Soluble dietary fibers improved the sensory quality of the formulation containing eicosapentaenoic acid and docosahexaenoic acid. The efficiency of cluster analysis to discriminate individuals in subgroups was confirmed by one-way analysis of variance ( P < 0.003). Conclusion The ω-3 polyunsaturated fatty acid supplementation equivalent to fish consumed 2.5 to 3 times per week by a functional food-containing soluble dietary fiber showed no beneficial result in terms of changes in blood lipids in individuals classified according to different levels of lipidemia. Small numbers of patients in each cluster and possibly the low dose of fish oil and soluble dietary fibers used in this study may have also contributed to the lack of these differences. Multivariate techniques proved to be a very efficient tool to solve the heterogeneity problem usually observed in human designs and to evaluate the results within subgroups categorized by n variables extracted from the same population.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17234506</pmid><doi>10.1016/j.nut.2006.11.006</doi><tpages>11</tpages></addata></record> |
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| ispartof | Nutrition (Burbank, Los Angeles County, Calif.), 2007-02, Vol.23 (2), p.127-137 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland |
| subjects | Adolescent Adult Aged beta-glucans Biological and medical sciences biomarkers Blood blood glucose blood lipids Body mass index Cardiovascular diseases Cholesterol cholesterol metabolism Cholesterol, HDL - blood Cholesterol, LDL - blood Cluster Analysis Coronary Disease - blood Coronary Disease - prevention & control dietary fat Dietary fiber Dietary Fiber - administration & dosage Dietary Fiber - therapeutic use Docosahexaenoic acid Docosahexaenoic Acids - administration & dosage Docosahexaenoic Acids - therapeutic use Double-Blind Method Eicosapentaenoic acid Eicosapentaenoic Acid - administration & dosage Eicosapentaenoic Acid - therapeutic use Fatty acids Feeding. Feeding behavior Female Fibers Fish oils Food, Fortified Functional foods Functional foods & nutraceuticals Fundamental and applied biological sciences. Psychology Gastroenterology and Hepatology guar gum health foods health promotion Health risks Heterogeneity high density lipoprotein human nutrition Humans hyperlipidemia Hyperlipidemias - diet therapy Lipids Lipids - blood low density lipoprotein Male Middle Aged Multivariate Analysis omega-3 fatty acids Polyunsaturated fatty acids Risk Factors Solubility Soluble dietary fibers soluble fiber Triacylglycerol triacylglycerols Triglycerides - blood Variance analysis Vertebrates: anatomy and physiology, studies on body, several organs or systems ω-3 Polyunsaturated fatty acid |
| title | Effect of eicosapentaenoic/docosahexaenoic fatty acids and soluble fibers on blood lipids of individuals classified into different levels of lipidemia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T12%3A48%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20eicosapentaenoic/docosahexaenoic%20fatty%20acids%20and%20soluble%20fibers%20on%20blood%20lipids%20of%20individuals%20classified%20into%20different%20levels%20of%20lipidemia&rft.jtitle=Nutrition%20(Burbank,%20Los%20Angeles%20County,%20Calif.)&rft.au=Castro,%20Inar%20A.,%20Ph.D&rft.date=2007-02-01&rft.volume=23&rft.issue=2&rft.spage=127&rft.epage=137&rft.pages=127-137&rft.issn=0899-9007&rft.eissn=1873-1244&rft.coden=NUTRER&rft_id=info:doi/10.1016/j.nut.2006.11.006&rft_dat=%3Cproquest_cross%3E3556046901%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1644791329&rft_id=info:pmid/17234506&rft_els_id=S0899900706003972&rfr_iscdi=true |