Duration of corneal anesthesia following topical administration of 0.5% proparacaine hydrochloride solution in clinically normal cats
To determine duration of corneal anesthesia following topical administration of 0.5% proparacaine hydrochloride solution in domestic shorthair (DSH) cats. 20 clinically normal DSH cats. Baseline corneal touch threshold (CCT) was established by use of a Cochet-Bonnet aesthesiometer. Treatment consist...
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| Veröffentlicht in: | American journal of veterinary research 2006-10, Vol.67 (10), p.1780-1782 |
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| container_title | American journal of veterinary research |
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| creator | Binder, D.R Herring, I.P |
| description | To determine duration of corneal anesthesia following topical administration of 0.5% proparacaine hydrochloride solution in domestic shorthair (DSH) cats.
20 clinically normal DSH cats.
Baseline corneal touch threshold (CCT) was established by use of a Cochet-Bonnet aesthesiometer. Treatment consisted of a single 50-microL topical application of an ophthalmic preparation of 0.5% proparacaine solution to a randomly selected eye of each cat. The corneal touch threshold was assessed 1 and 5 minutes after application to the cornea and at 5- minute intervals thereafter for 60 minutes.
Corneal sensitivity, as determined by Cochet-Bonnet aesthesiometry, was significantly reduced from baseline for 25 minutes following topical administration of ophthalmic proparacaine. Maximal anesthetic effect lasted 5 minutes.
As determined by Cochet-Bonnet aesthesiometry, duration of anesthetic effects on the cornea induced by a single topical application of an ophthalmic preparation of 0.5% proparacaine solution in DSH cats is considerably shorter than the reported duration of corneal anesthesia in dogs. |
| doi_str_mv | 10.2460/ajvr.67.10.1780 |
| format | Article |
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20 clinically normal DSH cats.
Baseline corneal touch threshold (CCT) was established by use of a Cochet-Bonnet aesthesiometer. Treatment consisted of a single 50-microL topical application of an ophthalmic preparation of 0.5% proparacaine solution to a randomly selected eye of each cat. The corneal touch threshold was assessed 1 and 5 minutes after application to the cornea and at 5- minute intervals thereafter for 60 minutes.
Corneal sensitivity, as determined by Cochet-Bonnet aesthesiometry, was significantly reduced from baseline for 25 minutes following topical administration of ophthalmic proparacaine. Maximal anesthetic effect lasted 5 minutes.
As determined by Cochet-Bonnet aesthesiometry, duration of anesthetic effects on the cornea induced by a single topical application of an ophthalmic preparation of 0.5% proparacaine solution in DSH cats is considerably shorter than the reported duration of corneal anesthesia in dogs.</description><identifier>ISSN: 0002-9645</identifier><identifier>EISSN: 1943-5681</identifier><identifier>DOI: 10.2460/ajvr.67.10.1780</identifier><identifier>PMID: 17014333</identifier><language>eng</language><publisher>United States</publisher><subject>Administration, Topical ; anesthesia ; Anesthesia, Local - veterinary ; anesthetics ; Anesthetics, Local - administration & dosage ; Anesthetics, Local - pharmacology ; Animals ; cats ; Cats - metabolism ; cornea ; Cornea - drug effects ; duration ; Health ; Ophthalmic Solutions ; pharmacokinetics ; proparacaine ; Propoxycaine - administration & dosage ; Propoxycaine - pharmacology ; Random Allocation ; topical application</subject><ispartof>American journal of veterinary research, 2006-10, Vol.67 (10), p.1780-1782</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-853caa24b954566f83581dabcf101cac983f16647fbd9afcb9651c6557e2317d3</citedby><cites>FETCH-LOGICAL-c360t-853caa24b954566f83581dabcf101cac983f16647fbd9afcb9651c6557e2317d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17014333$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Binder, D.R</creatorcontrib><creatorcontrib>Herring, I.P</creatorcontrib><title>Duration of corneal anesthesia following topical administration of 0.5% proparacaine hydrochloride solution in clinically normal cats</title><title>American journal of veterinary research</title><addtitle>Am J Vet Res</addtitle><description>To determine duration of corneal anesthesia following topical administration of 0.5% proparacaine hydrochloride solution in domestic shorthair (DSH) cats.
20 clinically normal DSH cats.
Baseline corneal touch threshold (CCT) was established by use of a Cochet-Bonnet aesthesiometer. Treatment consisted of a single 50-microL topical application of an ophthalmic preparation of 0.5% proparacaine solution to a randomly selected eye of each cat. The corneal touch threshold was assessed 1 and 5 minutes after application to the cornea and at 5- minute intervals thereafter for 60 minutes.
Corneal sensitivity, as determined by Cochet-Bonnet aesthesiometry, was significantly reduced from baseline for 25 minutes following topical administration of ophthalmic proparacaine. Maximal anesthetic effect lasted 5 minutes.
As determined by Cochet-Bonnet aesthesiometry, duration of anesthetic effects on the cornea induced by a single topical application of an ophthalmic preparation of 0.5% proparacaine solution in DSH cats is considerably shorter than the reported duration of corneal anesthesia in dogs.</description><subject>Administration, Topical</subject><subject>anesthesia</subject><subject>Anesthesia, Local - veterinary</subject><subject>anesthetics</subject><subject>Anesthetics, Local - administration & dosage</subject><subject>Anesthetics, Local - pharmacology</subject><subject>Animals</subject><subject>cats</subject><subject>Cats - metabolism</subject><subject>cornea</subject><subject>Cornea - drug effects</subject><subject>duration</subject><subject>Health</subject><subject>Ophthalmic Solutions</subject><subject>pharmacokinetics</subject><subject>proparacaine</subject><subject>Propoxycaine - administration & dosage</subject><subject>Propoxycaine - pharmacology</subject><subject>Random Allocation</subject><subject>topical application</subject><issn>0002-9645</issn><issn>1943-5681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE9v1DAQxS0EotvCmRv4Um7ZevwvzhGVUpAq9QA9W45jd1058WInoP0A_d447Eo9jUbze0_zHkIfgGwpl-TKPP3JW9lu6w6tIq_QBjrOGiEVvEYbQghtOsnFGTov5YkQoArEW3QGLQHOGNug569LNnNIE04e25QnZyI2kyvzzpVgsE8xpr9hesRz2ge7HocxTKHMLzKyFZd4n9PeZGNNmBzeHYac7C6mHAaHS4rLfzZM2MYqrjbxgKeUx-pnzVzeoTfexOLen-YFevh28-v6e3N3f_vj-stdY5kkc6MEs8ZQ3neCCym9YkLBYHrrgYA1tlPMg5S89f3QGW_7TgqwUojWUQbtwC7Q56Nv_fb3UkPqMRTrYqyJ01K0VB3litIKXh1Bm1Mp2Xm9z2E0-aCB6LV5vTavZbvua_NV8fFkvfSjG174U9UV-HQEvEnaPOZQ9MNPSoARACp4q9g_sPGL0A</recordid><startdate>20061001</startdate><enddate>20061001</enddate><creator>Binder, D.R</creator><creator>Herring, I.P</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061001</creationdate><title>Duration of corneal anesthesia following topical administration of 0.5% proparacaine hydrochloride solution in clinically normal cats</title><author>Binder, D.R ; Herring, I.P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-853caa24b954566f83581dabcf101cac983f16647fbd9afcb9651c6557e2317d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Administration, Topical</topic><topic>anesthesia</topic><topic>Anesthesia, Local - veterinary</topic><topic>anesthetics</topic><topic>Anesthetics, Local - administration & dosage</topic><topic>Anesthetics, Local - pharmacology</topic><topic>Animals</topic><topic>cats</topic><topic>Cats - metabolism</topic><topic>cornea</topic><topic>Cornea - drug effects</topic><topic>duration</topic><topic>Health</topic><topic>Ophthalmic Solutions</topic><topic>pharmacokinetics</topic><topic>proparacaine</topic><topic>Propoxycaine - administration & dosage</topic><topic>Propoxycaine - pharmacology</topic><topic>Random Allocation</topic><topic>topical application</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Binder, D.R</creatorcontrib><creatorcontrib>Herring, I.P</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of veterinary research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Binder, D.R</au><au>Herring, I.P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Duration of corneal anesthesia following topical administration of 0.5% proparacaine hydrochloride solution in clinically normal cats</atitle><jtitle>American journal of veterinary research</jtitle><addtitle>Am J Vet Res</addtitle><date>2006-10-01</date><risdate>2006</risdate><volume>67</volume><issue>10</issue><spage>1780</spage><epage>1782</epage><pages>1780-1782</pages><issn>0002-9645</issn><eissn>1943-5681</eissn><abstract>To determine duration of corneal anesthesia following topical administration of 0.5% proparacaine hydrochloride solution in domestic shorthair (DSH) cats.
20 clinically normal DSH cats.
Baseline corneal touch threshold (CCT) was established by use of a Cochet-Bonnet aesthesiometer. Treatment consisted of a single 50-microL topical application of an ophthalmic preparation of 0.5% proparacaine solution to a randomly selected eye of each cat. The corneal touch threshold was assessed 1 and 5 minutes after application to the cornea and at 5- minute intervals thereafter for 60 minutes.
Corneal sensitivity, as determined by Cochet-Bonnet aesthesiometry, was significantly reduced from baseline for 25 minutes following topical administration of ophthalmic proparacaine. Maximal anesthetic effect lasted 5 minutes.
As determined by Cochet-Bonnet aesthesiometry, duration of anesthetic effects on the cornea induced by a single topical application of an ophthalmic preparation of 0.5% proparacaine solution in DSH cats is considerably shorter than the reported duration of corneal anesthesia in dogs.</abstract><cop>United States</cop><pmid>17014333</pmid><doi>10.2460/ajvr.67.10.1780</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0002-9645 1943-5681 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Administration, Topical anesthesia Anesthesia, Local - veterinary anesthetics Anesthetics, Local - administration & dosage Anesthetics, Local - pharmacology Animals cats Cats - metabolism cornea Cornea - drug effects duration Health Ophthalmic Solutions pharmacokinetics proparacaine Propoxycaine - administration & dosage Propoxycaine - pharmacology Random Allocation topical application |
| title | Duration of corneal anesthesia following topical administration of 0.5% proparacaine hydrochloride solution in clinically normal cats |
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