Development of a pharmacokinetic/pharmacodynamic model for carvedilol to predict beta1-blockade in patients with congestive heart failure

To determine whether the controlled-release (CR) formulation of carvedilol given once daily provides 24-hour beta1-receptor blockade similar to the currently marketed immediate-release (IR) formulation given twice daily, changes in exercise-induced heart rate after bicycle ergometry were measured. T...

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Veröffentlicht in:	The American journal of cardiology 2006-10, Vol.98 (7A), p.27L-31L
Hauptverfasser:	Tenero, David M, Henderson, Linda S, Campanile, Andrea M, Baidoo, Charlotte A, Boyle, Duane
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adrenergic beta-Antagonists - administration & dosage Adrenergic beta-Antagonists - blood Adrenergic beta-Antagonists - pharmacokinetics Adrenergic beta-Antagonists - pharmacology Adrenergic beta-Antagonists - therapeutic use Area Under Curve Beta blockers Carbazoles - administration & dosage Carbazoles - blood Carbazoles - pharmacokinetics Carbazoles - pharmacology Carbazoles - therapeutic use Clinical trials Clinical Trials as Topic Delayed-Action Preparations - administration & dosage Delayed-Action Preparations - pharmacokinetics Delayed-Action Preparations - pharmacology Delayed-Action Preparations - therapeutic use Drug dosages Heart failure Heart Failure - drug therapy Heart Failure - pathology Humans Kinetics Models, Statistical Pharmacology Propanolamines - administration & dosage Propanolamines - blood Propanolamines - pharmacokinetics Propanolamines - pharmacology Propanolamines - therapeutic use Severity of Illness Index
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