Enzymatic and Nonenzymatic Synthesis of Glutathione Conjugates:  Application to the Understanding of a Parasite's Defense System and Alternative to the Discovery of Potent Glutathione S-Transferase Inhibitors

A primary pathway for metabolism of electrophilic compounds in Schistosoma japonicum involves glutathione S-transferase (SjGST)-catalyzed formation of glutathione (GSH) conjugates. As part of a program aimed at gaining a better understanding of the defense system of parasites, a series of aromatic h...

Ausführliche Beschreibung