Multiple CD4 and CD8 T-cell activation parameters predict vaccine efficacy in vivo mediated by individual DC-activating agonists

Abstract A systematic comparison of the immunostimulatory capacity of TLR 2, 3, 4, 5, 7 and 9 agonists and an agonistic CD40-specific antibody was performed in a single long peptide vaccination model. All adjuvants activated DC in vitro but not all induced a strong functional T-cell response in vivo...

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Veröffentlicht in:	Vaccine 2007-02, Vol.25 (8), p.1379-1389
Hauptverfasser:	Welters, Marij J.P, Bijker, Martijn S, van den Eeden, Susan J.F, Franken, Kees L.M.C, Melief, Cornelis J.M, Offringa, Rienk, van der Burg, Sjoerd H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology Allergy and Immunology Amino Acid Sequence Animals Antibodies - immunology Antibodies - pharmacology Antibody Specificity Applied microbiology Biological and medical sciences Cancer Vaccines - immunology CD4-Positive T-Lymphocytes - immunology CD40 Antigens - immunology CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor Dendritic Cells - immunology Female Fundamental and applied biological sciences. Psychology Human papillomavirus 16 - immunology Immunity Lymphocyte Activation Mice Mice, Inbred C57BL Microbiology Molecular Sequence Data Neoplasms, Experimental - immunology Neoplasms, Experimental - therapy Oncogene Proteins, Viral - immunology Papillomavirus E7 Proteins Toll-Like Receptors - agonists Toll-Like Receptors - immunology Vaccine efficacy Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Subunit - immunology Viral infection
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