Ccr5 But Not Ccr1 Deficiency Reduces Development of Diet-Induced Atherosclerosis in Mice

OBJECTIVE—Chemokines and their receptors are crucially involved in the development of atherosclerotic lesions by directing monocyte and T cell recruitment. The CC-chemokine receptors 1 (CCR1) and 5 (CCR5) expressed on these cells bind chemokines implicated in atherosclerosis, namely CCL5/RANTES. Alt...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2007-02, Vol.27 (2), p.373-379
Hauptverfasser:	Braunersreuther, Vincent, Zernecke, Alma, Arnaud, Claire, Liehn, Elisa A, Steffens, Sabine, Shagdarsuren, Erdenechimeg, Bidzhekov, Kiril, Burger, Fabienne, Pelli, Graziano, Luckow, Bruno, Mach, François, Weber, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins E - genetics Apolipoproteins E - metabolism Atherosclerosis (general aspects, experimental research) Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - prevention & control Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Carotid Stenosis - metabolism Carotid Stenosis - physiopathology Carotid Stenosis - prevention & control Cell Proliferation Cholesterol, Dietary - adverse effects Cytokines - metabolism Dietary Fats - adverse effects Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Drug toxicity and drugs side effects treatment Female GATA3 Transcription Factor - genetics GATA3 Transcription Factor - metabolism Gene Expression Regulation Hepatitis A Virus Cellular Receptor 2 Interleukin-10 - genetics Interleukin-10 - metabolism Lymph Nodes - cytology Lymph Nodes - metabolism Medical sciences Membrane Proteins Mice Mice, Transgenic Pharmacology. Drug treatments Phenotype Receptors, CCR1 Receptors, CCR5 - genetics Receptors, CCR5 - metabolism Receptors, Chemokine - genetics Receptors, Chemokine - metabolism Receptors, Virus - genetics Receptors, Virus - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Spleen - cytology Spleen - metabolism Th1 Cells - cytology Th1 Cells - metabolism Toxicity: blood Toxicity: digestive system
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