Inhibitory effect of obovatol on nitric oxide production and activation of NF-kappaB/MAP kinases in lipopolysaccharide-treated RAW 264.7cells

The components of Magnolia obovata are known to have many pharmacological activities. In this study, we investigated the effects of obovatol, a neolignan compound isolated from the leaves of M. obovata, on nitric oxide (NO) production and NF-kappaB activity in lipopolysaccharide (LPS)-activated RAW...

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Veröffentlicht in:	European journal of pharmacology 2007-02, Vol.556 (1-3), p.181-189
Hauptverfasser:	Choi, Myoung Suk, Lee, Seung Ho, Cho, Ho Seong, Kim, Youngsoo, Yun, Yeo Pyo, Jung, Hai Young, Jung, Jae Kyoung, Lee, Bum Chun, Pyo, Hyeong Bae, Hong, Jin Tae
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthracenes - pharmacology Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biphenyl Compounds - pharmacology Butadienes - pharmacology Cell Line Cyclooxygenase 2 - biosynthesis Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Extracellular Signal-Regulated MAP Kinases - metabolism Lipopolysaccharides - pharmacology Macrophages - drug effects Macrophages - metabolism Magnolia - chemistry MAP Kinase Kinase 4 - antagonists & inhibitors MAP Kinase Kinase 4 - metabolism Mice Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism Nitric Oxide - antagonists & inhibitors Nitric Oxide - biosynthesis Nitric Oxide Synthase Type II - antagonists & inhibitors Nitric Oxide Synthase Type II - metabolism Nitriles - pharmacology Phenyl Ethers - pharmacology
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