Proton magnetic resonance spectroscopy reveals an abnormality in the anterior cingulate of a subgroup of obsessive–compulsive disorder patients
Abstract Numerous neuroimaging studies have suggested that obsessive–compulsive disorder (OCD) patients had a neurobiological abnormality in the frontal-subcortical circuits. On the other hand, there are distinct differences in the responses to pharmacological treatment among OCD patients. In the pr...
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| Veröffentlicht in: | Psychiatry research 2007-01, Vol.154 (1), p.85-92 |
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| creator | Sumitani, Satsuki Harada, Masafumi Kubo, Hitoshi Ohmori, Tetsuro |
| description | Abstract Numerous neuroimaging studies have suggested that obsessive–compulsive disorder (OCD) patients had a neurobiological abnormality in the frontal-subcortical circuits. On the other hand, there are distinct differences in the responses to pharmacological treatment among OCD patients. In the present study, we measured the concentration of N -acetyl aspartate (NAA), a putative marker of neuronal viability, with proton magnetic resonance spectroscopy (MRS) in OCD patients with different pharmacological responses. Participants comprised 20 patients and 26 healthy control subjects. OCD patients were divided into three groups according to the pharmacological response; responders to a selective serotonin reuptake inhibitor (SSRI) (group A: n = 7), responders to SSRI with an atypical antipsychotic (group B: n = 8) and non-responders to either SSRI or SSRI with an atypical antipsychotic (group C: n = 5). Short echo proton MRS was used to measure NAA concentrations in the anterior cingulate, the left basal ganglia and the left prefrontal lobe of subjects. A significantly lower NAA concentration was observed only in group B compared with control subjects in the anterior cingulate. Our results suggest that a subgroup of OCD patients who respond to an SSRI with an atypical antipsychotic have distinct biological abnormalities in the anterior cingulate. |
| doi_str_mv | 10.1016/j.pscychresns.2006.02.003 |
| format | Article |
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On the other hand, there are distinct differences in the responses to pharmacological treatment among OCD patients. In the present study, we measured the concentration of N -acetyl aspartate (NAA), a putative marker of neuronal viability, with proton magnetic resonance spectroscopy (MRS) in OCD patients with different pharmacological responses. Participants comprised 20 patients and 26 healthy control subjects. OCD patients were divided into three groups according to the pharmacological response; responders to a selective serotonin reuptake inhibitor (SSRI) (group A: n = 7), responders to SSRI with an atypical antipsychotic (group B: n = 8) and non-responders to either SSRI or SSRI with an atypical antipsychotic (group C: n = 5). Short echo proton MRS was used to measure NAA concentrations in the anterior cingulate, the left basal ganglia and the left prefrontal lobe of subjects. A significantly lower NAA concentration was observed only in group B compared with control subjects in the anterior cingulate. Our results suggest that a subgroup of OCD patients who respond to an SSRI with an atypical antipsychotic have distinct biological abnormalities in the anterior cingulate.</description><identifier>ISSN: 0925-4927</identifier><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7506</identifier><identifier>DOI: 10.1016/j.pscychresns.2006.02.003</identifier><identifier>PMID: 17208418</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Adult and adolescent clinical studies ; Antipsychotic Agents - therapeutic use ; Anxiety disorders. Neuroses ; Aspartic Acid - analogs & derivatives ; Aspartic Acid - metabolism ; Atypical antipsychotic ; Basal ganglia ; Basal Ganglia - drug effects ; Basal Ganglia - physiopathology ; Benzodiazepines - therapeutic use ; Biological and medical sciences ; Dominance, Cerebral - physiology ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Energy Metabolism - drug effects ; Energy Metabolism - physiology ; Female ; Fluvoxamine - therapeutic use ; Frontal Lobe - drug effects ; Frontal Lobe - physiopathology ; Gyrus Cinguli - drug effects ; Gyrus Cinguli - physiopathology ; Humans ; Magnetic Resonance Spectroscopy ; Male ; Medical sciences ; Middle Aged ; N-acetyl aspartate (NAA) ; Nerve Net - drug effects ; Nerve Net - physiopathology ; Obsessive-Compulsive Disorder - diagnosis ; Obsessive-Compulsive Disorder - drug therapy ; Obsessive-Compulsive Disorder - physiopathology ; Obsessive-compulsive disorders ; Paroxetine - therapeutic use ; Pharmacological response ; Prefrontal Cortex - drug effects ; Prefrontal Cortex - physiopathology ; Prefrontal lobe ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Radiology ; Risperidone - therapeutic use ; Selective serotonin reuptake inhibitor (SSRI) ; Serotonin Uptake Inhibitors - therapeutic use ; Treatment Outcome</subject><ispartof>Psychiatry research, 2007-01, Vol.154 (1), p.85-92</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2006 Elsevier Ireland Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-c9dffa79d2496aa6d8a4f739a98bb9013aff199c2d3472f491acd69c146b7a1b3</citedby><cites>FETCH-LOGICAL-c526t-c9dffa79d2496aa6d8a4f739a98bb9013aff199c2d3472f491acd69c146b7a1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0925492706000412$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18471213$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17208418$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sumitani, Satsuki</creatorcontrib><creatorcontrib>Harada, Masafumi</creatorcontrib><creatorcontrib>Kubo, Hitoshi</creatorcontrib><creatorcontrib>Ohmori, Tetsuro</creatorcontrib><title>Proton magnetic resonance spectroscopy reveals an abnormality in the anterior cingulate of a subgroup of obsessive–compulsive disorder patients</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>Abstract Numerous neuroimaging studies have suggested that obsessive–compulsive disorder (OCD) patients had a neurobiological abnormality in the frontal-subcortical circuits. On the other hand, there are distinct differences in the responses to pharmacological treatment among OCD patients. In the present study, we measured the concentration of N -acetyl aspartate (NAA), a putative marker of neuronal viability, with proton magnetic resonance spectroscopy (MRS) in OCD patients with different pharmacological responses. Participants comprised 20 patients and 26 healthy control subjects. OCD patients were divided into three groups according to the pharmacological response; responders to a selective serotonin reuptake inhibitor (SSRI) (group A: n = 7), responders to SSRI with an atypical antipsychotic (group B: n = 8) and non-responders to either SSRI or SSRI with an atypical antipsychotic (group C: n = 5). Short echo proton MRS was used to measure NAA concentrations in the anterior cingulate, the left basal ganglia and the left prefrontal lobe of subjects. A significantly lower NAA concentration was observed only in group B compared with control subjects in the anterior cingulate. Our results suggest that a subgroup of OCD patients who respond to an SSRI with an atypical antipsychotic have distinct biological abnormalities in the anterior cingulate.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Anxiety disorders. Neuroses</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - metabolism</subject><subject>Atypical antipsychotic</subject><subject>Basal ganglia</subject><subject>Basal Ganglia - drug effects</subject><subject>Basal Ganglia - physiopathology</subject><subject>Benzodiazepines - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Dominance, Cerebral - physiology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Therapy, Combination</subject><subject>Energy Metabolism - drug effects</subject><subject>Energy Metabolism - physiology</subject><subject>Female</subject><subject>Fluvoxamine - therapeutic use</subject><subject>Frontal Lobe - drug effects</subject><subject>Frontal Lobe - physiopathology</subject><subject>Gyrus Cinguli - drug effects</subject><subject>Gyrus Cinguli - physiopathology</subject><subject>Humans</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>N-acetyl aspartate (NAA)</subject><subject>Nerve Net - drug effects</subject><subject>Nerve Net - physiopathology</subject><subject>Obsessive-Compulsive Disorder - diagnosis</subject><subject>Obsessive-Compulsive Disorder - drug therapy</subject><subject>Obsessive-Compulsive Disorder - physiopathology</subject><subject>Obsessive-compulsive disorders</subject><subject>Paroxetine - therapeutic use</subject><subject>Pharmacological response</subject><subject>Prefrontal Cortex - drug effects</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Prefrontal lobe</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Radiology</subject><subject>Risperidone - therapeutic use</subject><subject>Selective serotonin reuptake inhibitor (SSRI)</subject><subject>Serotonin Uptake Inhibitors - therapeutic use</subject><subject>Treatment Outcome</subject><issn>0925-4927</issn><issn>0165-1781</issn><issn>1872-7506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUs2q1DAULqJ4x6uvIHGhu45JmkmbjSCDf3BBQV2HND2dm7FNak460J2vIL6hT2LKDFxx5Sqcw_cTvu8UxTNGt4wy-fK4ndAu9jYCetxySuWW8i2l1b1iw5qal_WOyvvFhiq-K4Xi9VXxCPFIKa8aWT0srljNaSNYsyl-foohBU9Gc_CQnCVZM3jjLRCcwKYY0IZpyesTmAGJ8cS0PsTRDC4txHmSbiFvE0QXIrHOH-bBJCChJ4bg3B5imKd1Ci0CojvB7x-_bBineVgH0jkMsYNIJpMc-ISPiwd9doInl_e6-Pr2zZf9-_Lm47sP-9c3pd1xmUqrur43teq4UNIY2TVG9HWljGraVlFWmb5nSlneVaLmvVDM2E4qy4Rsa8Pa6rp4cdadYvg-AyY9OrQwDMZDmFHLRnEqRJOB6gy0OQyM0OsputHERTOq1z70Uf_Vh1770JTr3EfmPr2YzO0I3R3zUkAGPL8ADFoz9DFH7_AO14iacbYK7c84yJGcHESNNsdloXMx16S74P7rO6_-UbGD8y4bf4MF8Bjm6HPmmmnMBP15PaD1fqiklArGqz98jMqA</recordid><startdate>20070115</startdate><enddate>20070115</enddate><creator>Sumitani, Satsuki</creator><creator>Harada, Masafumi</creator><creator>Kubo, Hitoshi</creator><creator>Ohmori, Tetsuro</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070115</creationdate><title>Proton magnetic resonance spectroscopy reveals an abnormality in the anterior cingulate of a subgroup of obsessive–compulsive disorder patients</title><author>Sumitani, Satsuki ; Harada, Masafumi ; Kubo, Hitoshi ; Ohmori, Tetsuro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-c9dffa79d2496aa6d8a4f739a98bb9013aff199c2d3472f491acd69c146b7a1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Anxiety disorders. Neuroses</topic><topic>Aspartic Acid - analogs & derivatives</topic><topic>Aspartic Acid - metabolism</topic><topic>Atypical antipsychotic</topic><topic>Basal ganglia</topic><topic>Basal Ganglia - drug effects</topic><topic>Basal Ganglia - physiopathology</topic><topic>Benzodiazepines - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Dominance, Cerebral - physiology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Therapy, Combination</topic><topic>Energy Metabolism - drug effects</topic><topic>Energy Metabolism - physiology</topic><topic>Female</topic><topic>Fluvoxamine - therapeutic use</topic><topic>Frontal Lobe - drug effects</topic><topic>Frontal Lobe - physiopathology</topic><topic>Gyrus Cinguli - drug effects</topic><topic>Gyrus Cinguli - physiopathology</topic><topic>Humans</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>N-acetyl aspartate (NAA)</topic><topic>Nerve Net - drug effects</topic><topic>Nerve Net - physiopathology</topic><topic>Obsessive-Compulsive Disorder - diagnosis</topic><topic>Obsessive-Compulsive Disorder - drug therapy</topic><topic>Obsessive-Compulsive Disorder - physiopathology</topic><topic>Obsessive-compulsive disorders</topic><topic>Paroxetine - therapeutic use</topic><topic>Pharmacological response</topic><topic>Prefrontal Cortex - drug effects</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Prefrontal lobe</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Radiology</topic><topic>Risperidone - therapeutic use</topic><topic>Selective serotonin reuptake inhibitor (SSRI)</topic><topic>Serotonin Uptake Inhibitors - therapeutic use</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sumitani, Satsuki</creatorcontrib><creatorcontrib>Harada, Masafumi</creatorcontrib><creatorcontrib>Kubo, Hitoshi</creatorcontrib><creatorcontrib>Ohmori, Tetsuro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sumitani, Satsuki</au><au>Harada, Masafumi</au><au>Kubo, Hitoshi</au><au>Ohmori, Tetsuro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proton magnetic resonance spectroscopy reveals an abnormality in the anterior cingulate of a subgroup of obsessive–compulsive disorder patients</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>2007-01-15</date><risdate>2007</risdate><volume>154</volume><issue>1</issue><spage>85</spage><epage>92</epage><pages>85-92</pages><issn>0925-4927</issn><issn>0165-1781</issn><eissn>1872-7506</eissn><abstract>Abstract Numerous neuroimaging studies have suggested that obsessive–compulsive disorder (OCD) patients had a neurobiological abnormality in the frontal-subcortical circuits. On the other hand, there are distinct differences in the responses to pharmacological treatment among OCD patients. In the present study, we measured the concentration of N -acetyl aspartate (NAA), a putative marker of neuronal viability, with proton magnetic resonance spectroscopy (MRS) in OCD patients with different pharmacological responses. Participants comprised 20 patients and 26 healthy control subjects. OCD patients were divided into three groups according to the pharmacological response; responders to a selective serotonin reuptake inhibitor (SSRI) (group A: n = 7), responders to SSRI with an atypical antipsychotic (group B: n = 8) and non-responders to either SSRI or SSRI with an atypical antipsychotic (group C: n = 5). Short echo proton MRS was used to measure NAA concentrations in the anterior cingulate, the left basal ganglia and the left prefrontal lobe of subjects. A significantly lower NAA concentration was observed only in group B compared with control subjects in the anterior cingulate. Our results suggest that a subgroup of OCD patients who respond to an SSRI with an atypical antipsychotic have distinct biological abnormalities in the anterior cingulate.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>17208418</pmid><doi>10.1016/j.pscychresns.2006.02.003</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Antipsychotic Agents - therapeutic use Anxiety disorders. Neuroses Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Atypical antipsychotic Basal ganglia Basal Ganglia - drug effects Basal Ganglia - physiopathology Benzodiazepines - therapeutic use Biological and medical sciences Dominance, Cerebral - physiology Dose-Response Relationship, Drug Drug Therapy, Combination Energy Metabolism - drug effects Energy Metabolism - physiology Female Fluvoxamine - therapeutic use Frontal Lobe - drug effects Frontal Lobe - physiopathology Gyrus Cinguli - drug effects Gyrus Cinguli - physiopathology Humans Magnetic Resonance Spectroscopy Male Medical sciences Middle Aged N-acetyl aspartate (NAA) Nerve Net - drug effects Nerve Net - physiopathology Obsessive-Compulsive Disorder - diagnosis Obsessive-Compulsive Disorder - drug therapy Obsessive-Compulsive Disorder - physiopathology Obsessive-compulsive disorders Paroxetine - therapeutic use Pharmacological response Prefrontal Cortex - drug effects Prefrontal Cortex - physiopathology Prefrontal lobe Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Radiology Risperidone - therapeutic use Selective serotonin reuptake inhibitor (SSRI) Serotonin Uptake Inhibitors - therapeutic use Treatment Outcome |
| title | Proton magnetic resonance spectroscopy reveals an abnormality in the anterior cingulate of a subgroup of obsessive–compulsive disorder patients |
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