Stem Cells Are Units of Natural Selection in a Colonial Ascidian
Stem cells are highly conserved biological units of development and regeneration. Here we formally demonstrate that stem cell lineages are also legitimate units of natural selection. In a colonial ascidian, Botryllus schlosseri, vascular fusion between genetically distinct individuals results in cel...
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| Veröffentlicht in: | Cell 2005-12, Vol.123 (7), p.1351-1360 |
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| creator | Laird, Diana J. De Tomaso, Anthony W. Weissman, Irving L. |
| description | Stem cells are highly conserved biological units of development and regeneration. Here we formally demonstrate that stem cell lineages are also legitimate units of natural selection. In a colonial ascidian,
Botryllus schlosseri, vascular fusion between genetically distinct individuals results in cellular parasitism of somatic tissues, gametes, or both. We show that genetic hierarchies of somatic and gametic parasitism following fusion can be replicated by transplanting cells between colonies. We prospectively isolate a population of multipotent, self-renewing stem cells that retain their competitive phenotype upon transplantation. Their single-cell contribution to either somatic or germline fates, but not to both, is consistent with separate lineages of somatic and germline stem cells or pluripotent stem cells that differentiate according to the niche in which they land. Since fusion is restricted to individuals that share a fusion/histocompatibility allele, these data suggest that histocompatibility genes in
Botryllus evolved to protect the body from parasitic stem cells usurping asexual or sexual inheritance. |
| doi_str_mv | 10.1016/j.cell.2005.10.026 |
| format | Article |
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Botryllus schlosseri, vascular fusion between genetically distinct individuals results in cellular parasitism of somatic tissues, gametes, or both. We show that genetic hierarchies of somatic and gametic parasitism following fusion can be replicated by transplanting cells between colonies. We prospectively isolate a population of multipotent, self-renewing stem cells that retain their competitive phenotype upon transplantation. Their single-cell contribution to either somatic or germline fates, but not to both, is consistent with separate lineages of somatic and germline stem cells or pluripotent stem cells that differentiate according to the niche in which they land. Since fusion is restricted to individuals that share a fusion/histocompatibility allele, these data suggest that histocompatibility genes in
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Botryllus evolved to protect the body from parasitic stem cells usurping asexual or sexual inheritance.</description><subject>Animals</subject><subject>Botryllus</subject><subject>Botryllus schlosseri</subject><subject>Cell Differentiation</subject><subject>Cell Lineage</subject><subject>Cell Proliferation</subject><subject>Cells, Cultured</subject><subject>Germ Cells - cytology</subject><subject>Histocompatibility</subject><subject>Pluripotent Stem Cells - cytology</subject><subject>Selection, Genetic</subject><subject>Stem Cell Transplantation</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - physiology</subject><subject>Urochordata - cytology</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAUhYMozjj6B1xIVu5ak7ZJGnDhUHzBoItx1iGT3kCGPsakFfz3psyAO11dOJzzwf0QuqYkpYTyu11qoGnSjBAWg5Rk_ATNKZEiKajITtGcEJklJRfFDF2EsCOElIyxczSjPBeCiXyOHtYDtLiKnICXHvCmc0PAvcVvehi9bvAaGjCD6zvsOqxx1Td952K-DMbVTneX6MzqJsDV8S7Q5unxo3pJVu_Pr9VylZhCsiHRW5uDKKzh1rKcgeVScqst8IwVTBBqhc0s04xvZW5IXUigBWTWSjClkHW-QLcH7t73nyOEQbUuTP_rDvoxKF5KWkbUv0UqJRMl57GYHYrG9yF4sGrvXav9t6JETYLVTk07NQmesig4jm6O9HHbQv07ORqNhftDAaKMLwdeRVHQGaidjyJV3bu_-D_3TotW</recordid><startdate>20051229</startdate><enddate>20051229</enddate><creator>Laird, Diana J.</creator><creator>De Tomaso, Anthony W.</creator><creator>Weissman, Irving L.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20051229</creationdate><title>Stem Cells Are Units of Natural Selection in a Colonial Ascidian</title><author>Laird, Diana J. ; De Tomaso, Anthony W. ; Weissman, Irving L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-abf3e74fc6ff535ef6996fafe62545701f7f2f5a56b93c0d49e14e2ff9ec879d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Botryllus</topic><topic>Botryllus schlosseri</topic><topic>Cell Differentiation</topic><topic>Cell Lineage</topic><topic>Cell Proliferation</topic><topic>Cells, Cultured</topic><topic>Germ Cells - cytology</topic><topic>Histocompatibility</topic><topic>Pluripotent Stem Cells - cytology</topic><topic>Selection, Genetic</topic><topic>Stem Cell Transplantation</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells - physiology</topic><topic>Urochordata - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laird, Diana J.</creatorcontrib><creatorcontrib>De Tomaso, Anthony W.</creatorcontrib><creatorcontrib>Weissman, Irving L.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laird, Diana J.</au><au>De Tomaso, Anthony W.</au><au>Weissman, Irving L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stem Cells Are Units of Natural Selection in a Colonial Ascidian</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>2005-12-29</date><risdate>2005</risdate><volume>123</volume><issue>7</issue><spage>1351</spage><epage>1360</epage><pages>1351-1360</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>Stem cells are highly conserved biological units of development and regeneration. Here we formally demonstrate that stem cell lineages are also legitimate units of natural selection. In a colonial ascidian,
Botryllus schlosseri, vascular fusion between genetically distinct individuals results in cellular parasitism of somatic tissues, gametes, or both. We show that genetic hierarchies of somatic and gametic parasitism following fusion can be replicated by transplanting cells between colonies. We prospectively isolate a population of multipotent, self-renewing stem cells that retain their competitive phenotype upon transplantation. Their single-cell contribution to either somatic or germline fates, but not to both, is consistent with separate lineages of somatic and germline stem cells or pluripotent stem cells that differentiate according to the niche in which they land. Since fusion is restricted to individuals that share a fusion/histocompatibility allele, these data suggest that histocompatibility genes in
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| ispartof | Cell, 2005-12, Vol.123 (7), p.1351-1360 |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Botryllus Botryllus schlosseri Cell Differentiation Cell Lineage Cell Proliferation Cells, Cultured Germ Cells - cytology Histocompatibility Pluripotent Stem Cells - cytology Selection, Genetic Stem Cell Transplantation Stem Cells - cytology Stem Cells - physiology Urochordata - cytology |
| title | Stem Cells Are Units of Natural Selection in a Colonial Ascidian |
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